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公开(公告)号：US11242348B2
公开(公告)日：2022-02-08
申请号：US16651840
申请日：2018-09-27
发明人： Makoto Kamata , Hideyuki Sugiyama , Minoru Nakamura , Masataka Murakami , Shuhei Ikeda , Tomohiro Okawa , Hidekazu Tokuhara
IPC分类号： C07D487/10 , A61P25/28 , A61K9/20 , A61K9/48
摘要： The present invention provides a compound having an MAGL inhibitory action, and expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20220017530A1
公开(公告)日：2022-01-20
申请号：US17475733
申请日：2021-09-15
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61P1/10 , A61K31/4355
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US10435399B2
公开(公告)日：2019-10-08
申请号：US16049359
申请日：2018-07-30
发明人： Masahiro Ito , Hideyuki Sugiyama , Osamu Kubo , Fumiaki Kikuchi , Takeshi Yasui , Keiko Kakegawa , Zenichi Ikeda , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Akinori Toita , Takuto Kojima , Yasutomi Asano , Ayumu Sato , Hironobu Maezaki , Shinobu Sasaki , Hironori Kokubo , Misaki Homma , Minoru Sasaki , Yasuhiro Imaeda
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D487/04 , A61P25/28 , C07D471/04
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US09382188B2
公开(公告)日：2016-07-05
申请号：US14377953
申请日：2013-02-12
发明人： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC分类号： C07C59/135 , C07D405/14 , C07C255/46 , C07D309/06 , C07D231/12 , C07D333/38 , C07D401/12 , C07D239/26 , C07D239/34 , C07C317/44 , C07C229/34 , C07C233/47 , C07D271/10 , C07D277/24 , C07C255/37 , C07D285/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07C59/68 , C07C59/70 , C07C59/72 , C07D213/12 , C07C309/65 , C07C309/66 , C07C311/21 , C07C323/56 , C07C235/34 , C07C255/41
CPC分类号： C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
摘要： Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US20150045378A1
公开(公告)日：2015-02-12
申请号：US14377951
申请日：2013-02-12
发明人： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata
IPC分类号： C07D213/64 , C07D403/12 , C07D405/14 , C07D401/12 , C07D213/55
CPC分类号： C07D213/64 , C07D213/30 , C07D213/55 , C07D213/68 , C07D213/69 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/14
摘要： Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
摘要翻译： 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。
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公开(公告)号：US11274101B2
公开(公告)日：2022-03-15
申请号：US16651840
申请日：2018-09-27
发明人： Makoto Kamata , Hideyuki Sugiyama , Minoru Nakamura , Masataka Murakami , Shuhei Ikeda , Tomohiro Okawa , Hidekazu Tokuhara
IPC分类号： C07D487/10 , A61P25/28 , A61K9/20 , A61K9/48
摘要： The present invention provides a compound having an MAGL inhibitory action, and expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20150018422A1
公开(公告)日：2015-01-15
申请号：US14377953
申请日：2013-02-12
发明人： Seiji Miwatashi , Hideo Suzuki , Tomohiro Okawa , Yasufumi Miyamoto , Takeshi Yamasaki , Yuko Hitomi , Yasuhiro Hirata , Akito Shibuya
IPC分类号： C07C59/135
CPC分类号： C07C59/135 , C07C59/68 , C07C59/70 , C07C59/72 , C07C229/34 , C07C233/47 , C07C235/34 , C07C255/37 , C07C255/41 , C07C255/46 , C07C309/65 , C07C309/66 , C07C311/21 , C07C317/44 , C07C323/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/12 , C07D213/30 , C07D213/55 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/69 , C07D231/12 , C07D239/26 , C07D239/34 , C07D271/10 , C07D277/24 , C07D285/12 , C07D309/06 , C07D333/38 , C07D401/04 , C07D401/12 , C07D405/12 , C07D405/14
摘要： Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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公开(公告)号：US12084436B2
公开(公告)日：2024-09-10
申请号：US17426971
申请日：2020-01-29
发明人： Masahiro Ito , Takeshi Yamamoto , Keiko Kakegawa , Hideyuki Sugiyama , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Osamu Kubo , Akinori Toita , Takuto Kojima , Fumiaki Kikuchi , Minoru Sasaki , Misaki Homma , Yasuhiro Imaeda , Hironobu Maezaki , Shiinobu Sasaki , Ayumu Sato , Hirotaka Kamitani , Yasutomi Asano , Hironori Kokubo , Masato Yoshikawa
IPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.-
公开(公告)号：US11236099B2
公开(公告)日：2022-02-01
申请号：US16622632
申请日：2018-06-19
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61K31/4355 , A61P1/10
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US11186565B2
公开(公告)日：2021-11-30
申请号：US16499432
申请日：2018-03-29
发明人： Seiji Miwatashi , Yasufumi Miyamoto , Koji Watanabe , Yayoi Nakayama , Yuko Hitomi , Jumpei Aida , Nobuyuki Takakura , Hideki Furukawa , Naoyoshi Noguchi , Yasuhiro Hirata , Kazuaki Takami , Norihito Tokunaga , Tomohiro Okawa , Akito Shibuya , Shizuo Kasai , Toshitake Kobayashi , Tsuyoshi Maekawa
IPC分类号： C07D401/12 , C07C59/72 , C07D211/22 , C07D213/64 , C07D401/10 , C07D401/14 , C07D413/10
摘要： Provided is a novel aromatic ring compound which may have a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof may have a GPR40 agonist activity and a GLP-1 secretagogue action, may be useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and may afford superior efficacy.
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