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公开(公告)号：US09428470B2
公开(公告)日：2016-08-30
申请号：US14619464
申请日：2015-02-11
IPC分类号： C07D261/04 , C07D413/10
CPC分类号： C07D261/04 , C07D413/10
摘要： A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
摘要翻译： 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。
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公开(公告)号：US20150225354A1
公开(公告)日：2015-08-13
申请号：US14619464
申请日：2015-02-11
IPC分类号： C07D261/04 , C07D413/10
CPC分类号： C07D261/04 , C07D413/10
摘要： A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
摘要翻译： 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。
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公开(公告)号：US10919891B2
公开(公告)日：2021-02-16
申请号：US16608140
申请日：2018-04-26
发明人： Shuji Kitamura , Zenichi Ikeda , Sachie Morimoto , Minoru Ikoma , Koji Watanabe , Hideki Hirose , Takafumi Yukawa , Kenjiro Sato
IPC分类号： C07D471/04 , A61P9/06 , A61P9/12
摘要： The present invention provides a compound or a salt thereof having a calcium-sensing receptor antagonistic activity, and being expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like. The compounds represented by formula (I) or a salt thereof has a calcium-sensing receptor antagonistic activity, and is expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like, wherein each symbol is as described in the specification.
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公开(公告)号：US09969705B2
公开(公告)日：2018-05-15
申请号：US15117538
申请日：2015-02-12
IPC分类号： C07D307/81
CPC分类号： C07D307/81
摘要： A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
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公开(公告)号：US20140243310A1
公开(公告)日：2014-08-28
申请号：US14353622
申请日：2012-10-23
发明人： Tohru Yamashita , Takuya Fujimoto , Ryo Mizojiri , Kazuko Yonemori , Hideki Hirose , Zenichi Ikeda , Ikuo Fujimori , Kyoko Toyofuku , Tsuneo Yasuma , Nobuyuki Matsunaga
IPC分类号： C07D231/56 , C07D498/04 , C07D307/80 , C07D413/04 , C07D263/57 , C07D235/18
CPC分类号： C07D231/56 , A61K31/343 , A61K31/416 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4439 , C07D235/18 , C07D263/57 , C07D307/80 , C07D413/04 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译： 本发明提供由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。
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公开(公告)号：US10017487B2
公开(公告)日：2018-07-10
申请号：US15561613
申请日：2016-03-25
IPC分类号： C07D307/79 , C07F9/655 , C07D413/04
CPC分类号： C07D307/79 , A61K31/343 , A61K31/422 , A61K31/665 , A61P3/04 , A61P3/10 , C07D413/04 , C07F9/38 , C07F9/65517
摘要： The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].
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公开(公告)号：US20150225361A1
公开(公告)日：2015-08-13
申请号：US14619489
申请日：2015-02-11
IPC分类号： C07D307/81
CPC分类号： C07D307/81
摘要： A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
摘要翻译： 提供具有肠肽酶抑制作用的稠合杂环化合物和该化合物作为治疗或预防肥胖症，糖尿病等的药物的用途。 具体地，提供由下式（I）表示的化合物：其中每个符号如本文所定义，或其盐，并且使用该化合物作为治疗或预防肥胖，糖尿病等的药物。
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公开(公告)号：US11459325B2
公开(公告)日：2022-10-04
申请号：US16961476
申请日：2019-01-30
发明人： Yuta Tanaka , Tomohiro Ohashi , Zenichi Ikeda , Yuta Tanaka , Florian Pünner , Takeshi Yamamoto , Keiko Kakegawa , Fumiaki Kikuchi , Nao Morishita , Takahito Kasahara , Masaki Seto , Minoru Nakamura , Kazuaki Takami , Masataka Murakami , Masaki Daini , Satoshi Mikami , Minoru Sasaki
IPC分类号： C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00 , A61P25/28
摘要： The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.-
公开(公告)号：US10435399B2
公开(公告)日：2019-10-08
申请号：US16049359
申请日：2018-07-30
发明人： Masahiro Ito , Hideyuki Sugiyama , Osamu Kubo , Fumiaki Kikuchi , Takeshi Yasui , Keiko Kakegawa , Zenichi Ikeda , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Akinori Toita , Takuto Kojima , Yasutomi Asano , Ayumu Sato , Hironobu Maezaki , Shinobu Sasaki , Hironori Kokubo , Misaki Homma , Minoru Sasaki , Yasuhiro Imaeda
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D487/04 , A61P25/28 , C07D471/04
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号：US10023544B2
公开(公告)日：2018-07-17
申请号：US15117539
申请日：2015-02-12
IPC分类号： C07D261/04 , C07D413/10
摘要： A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
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