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公开(公告)号：US20200232052A1
公开(公告)日：2020-07-23
申请号：US16304803
申请日：2017-05-30
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
Abstract: Provided is a method of producing α-hydromuconic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing α-hydromuconic acid.
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公开(公告)号：US20220213514A1
公开(公告)日：2022-07-07
申请号：US17609964
申请日：2020-05-08
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: Disclosed is a genetically modified microorganism that produces 3-hydroxyadipic acid, α-hydromuconic acid. or adipic acid in high yield. A nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or the expression of the polypeptide is enhanced and the function of pyruvate kinase is impaired in the genetically modified microorganism: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 7; (b) a polypeptide having the same amino acid sequence as any one of those amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, andor added, and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA; (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of those amino acid sequences and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.
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公开(公告)号：US20200291435A1
公开(公告)日：2020-09-17
申请号：US16766979
申请日：2018-11-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: Disclosed is a genetically modified microorganism into which a nucleic acid encoding an enzyme that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA is introduced. In the genetically modified microorganism, a nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or expression of the polypeptide is enhanced: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 6 and 213, (b) a polypeptide composed of the same amino acid sequence as any one of the amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, and/or added, and having enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, and (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of the amino acid sequences and having activity to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.
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公开(公告)号：US20180223318A1
公开(公告)日：2018-08-09
申请号：US15580585
申请日：2016-06-09
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
IPC: C12P7/44
CPC classification number: C12P7/44
Abstract: A method of producing α-hydromuconic acid using a metabolic pathway of a microorganism is disclosed. The method of producing α-hydromuconic acid includes the step of culturing at least one type of microorganism having a capacity to produce α-hydromuconic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Delftia, and microorganisms belonging to the genus Shimwellia.
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公开(公告)号：US20230101086A1
公开(公告)日：2023-03-30
申请号：US17908059
申请日：2021-03-17
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: A genetically modified microorganism that can produce 3-hydroxyadipic acid and/or α-hydromuconic acid with a high yield; and a method of producing 3-hydroxyadipic acid and/or α-hydromuconic acid using the genetically modified microorganism, are disclosed. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid and/or α-hydromuconic acid, and has an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.
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Patent Agency Ranking
公开(公告)号：US20180142271A1
公开(公告)日：2018-05-24
申请号：US15580338
申请日：2016-06-09
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
Abstract: A novel method of producing 3-hydroxyadipic acid using a metabolic pathway of a microorganism is disclosed. The method of producing 3-hydroxyadipic acid includes the step of culturing at least one type of microorganism having a capacity to produce 3-hydroxyadipic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Corynebacterium, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Streptomyces, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Nocardioides, microorganisms belonging to the genus Brevibacterium, microorganisms belonging to the genus Delftia, microorganisms belonging to the genus Shimwellia, microorganisms belonging to the genus Aerobacter, and microorganisms belonging to the genus Rhizobium.
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公开(公告)号：US20240294583A1
公开(公告)日：2024-09-05
申请号：US17924145
申请日：2021-05-11
Applicant: TORAY INDUSTRIES, INC.
Inventor： Hitomi NAKAMURA , Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
IPC: C07K14/24 , C07K14/245 , C12P7/44 , C12P7/46 , C12P7/54
CPC classification number: C07K14/24 , C07K14/245 , C12P7/44 , C12P7/46 , C12P7/54
Abstract: A genetically modified microorganism containing a gene capable of expressing a mutated YeeX protein or a homolog thereof, which results from substitution, insertion, and/or deletion of one to several amino acids in the amino acid sequence of the wild-type YeeX protein or of a homolog thereof, has a higher capacity to produce an organic acid(s) than the genetically unmodified original microorganism.
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公开(公告)号：US20230392112A1
公开(公告)日：2023-12-07
申请号：US18034102
申请日：2021-11-10
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
CPC classification number: C12N1/205 , C12R2001/19 , C12N15/74 , C12P7/44
Abstract: Disclosed are a genetically modified microorganism that can produce 3-hydroxyadipic acid and/or α-hydromuconic acid in high yields, and the genetically modified microorganism. The genetically modified microorganism is a microorganism having an ability to produce 3-hydroxyadipic acid and/or α-hydromuconic acid, in which the reaction to generate acetyl-CoA from pyruvic acid is enhanced and function of pyruvate kinase and/or phosphotransferase system is reduced.
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公开(公告)号：US20220228178A1
公开(公告)日：2022-07-21
申请号：US17609841
申请日：2020-05-08
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: Disclosed are a genetically modified microorganism with an ability to produce 3-hydroxyadipic acid, α-hydromuconic acid, and/or adipic acid in high yield, and a method of producing 3-hydroxyadipic acid, α-hydromuconic acid, and/or adipic acid by using the genetically modified microorganism. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid, α-hydromuconic acid, and/or adipic acid and is deficient in the function of pyruvate kinase, in which the activities of phosphoenolpyruvate carboxykinase and of an enzyme that catalyzes the reaction of reducing 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA are enhanced.
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公开(公告)号：US20210047662A1
公开(公告)日：2021-02-18
申请号：US17088701
申请日：2020-11-04
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
IPC: C12P7/50
Abstract: A method of producing 3-oxoadipic acid from an aliphatic compound easily utilizable by a microorganism, such as a saccharide, by utilization of a metabolic pathway of the microorganism is disclosed. The method of producing 3-oxoadipic acid includes the step of culturing at least one type of microorganism having a capacity to produce 3-oxoadipic acid, selected from the group consisting of, for example, microorganisms belonging to the genus Serratia, microorganisms belonging to the genus Corynebacterium, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Shimwellia, microorganisms belonging to the genus Planomicrobium, microorganisms belonging to the genus Nocardioides, microorganisms belonging to the genus Yarrowia, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Rhodosporidium, microorganisms belonging to the genus Streptomyces, and microorganisms belonging to the genus Microbacterium.
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