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公开(公告)号：US20220411379A1
公开(公告)日：2022-12-29
申请号：US17777739
申请日：2020-11-18
Applicant: TORAY INDUSTRIES, INC.
Inventor： Daijiro TSUKAMOTO , Kenji KAWAMURA , Katsushige YAMADA , Masato AKAHIRA , Daisuke YAMAMOTO
IPC: C07D223/10
Abstract: The present invention relates to a method of producing ε-caprolactam, the method including the following steps (A) and (B): (A) a step of reacting 5-cyanovaleramide with hydrogen in an aqueous solvent in a presence of a hydrogenation catalyst to obtain a 5-cyanovaleramide hydrogenation reaction mixture; (B) a step of heating the 5-cyanovaleramide hydrogenation reaction mixture at a temperature of 180° C. or higher and 300° C. or lower in an aqueous solvent to obtain ε-caprolactam.
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公开(公告)号：US20200232052A1
公开(公告)日：2020-07-23
申请号：US16304803
申请日：2017-05-30
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
Abstract: Provided is a method of producing α-hydromuconic acid, the method including the step of culturing a microorganism belonging to the genus Serratia capable of producing α-hydromuconic acid.
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公开(公告)号：US20220213514A1
公开(公告)日：2022-07-07
申请号：US17609964
申请日：2020-05-08
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: Disclosed is a genetically modified microorganism that produces 3-hydroxyadipic acid, α-hydromuconic acid. or adipic acid in high yield. A nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or the expression of the polypeptide is enhanced and the function of pyruvate kinase is impaired in the genetically modified microorganism: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 7; (b) a polypeptide having the same amino acid sequence as any one of those amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, andor added, and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA; (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of those amino acid sequences and having an enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.
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公开(公告)号：US20170320819A1
公开(公告)日：2017-11-09
申请号：US15523120
申请日：2015-10-27
Applicant: TORAY INDUSTRIES, INC.
Inventor： Masateru ITO , Daijiro TSUKAMOTO , Kenji KAWAMURA , Kohei YAMASHITA , Masato AKAHIRA , Katsushige YAMADA , Koji YAMAUCHI
IPC: C07D201/08 , C08G69/14 , B01J23/44
CPC classification number: C07D201/08 , B01J23/44 , C07B61/00 , C07D223/10 , C08G69/14 , Y02P20/52
Abstract: A method for selective production of ε-caprolactam, wherein a substance inducible from a biomass resource is used as a material; the reaction process is short; ammonium sulfate is not produced as a by-product; and production of by-products is suppressed; is disclosed. The method for producing ε-caprolactam comprises the step of reacting a particular compound inducible from a biomass resource, such as α-hydromuconic acid, 3-hydroxyadipic acid, or 3-hydroxyadipic acid-3,6-lactone, or a salt thereof with hydrogen or ammonia.
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公开(公告)号：US20220356140A1
公开(公告)日：2022-11-10
申请号：US17763296
申请日：2020-09-24
Applicant: TORAY INDUSTRIES, INC.
Inventor： Daijiro TSUKAMOTO , Kenji KAWAMURA , Katsushige YAMADA , Masato AKAHIRA , Daisuke YAMAMOTO
Abstract: The present invention relates to a method of producing adipic acid, including a step (hydrogenation step) of reacting 3-hydroxyadipic acid-3,6-lactone with hydrogen in an aqueous solvent in a presence of a hydrogenation catalyst. The hydrogenation catalyst preferably includes one kind or two or more kinds of transition metal elements selected from the group consisting of palladium, platinum, ruthenium, rhodium, rhenium, nickel, cobalt, iron, iridium, osmium, copper, and chromium.
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Patent Agency Ranking
公开(公告)号：US20210032197A1
公开(公告)日：2021-02-04
申请号：US16966183
申请日：2019-02-05
Applicant: TORAY INDUSTRIES, INC.
Inventor： Daijiro TSUKAMOTO , Kenji KAWAMURA , Katsushige YAMADA , Masato AKAHIRA , Daisuke YAMAMOTO
IPC: C07C253/20
Abstract: The present invention provides a method of producing a nitrile from a primary amide, characterized in that the primary amide is subjected to a dehydration reaction in a supercritical fluid in the presence of an acid catalyst. The present invention achieves the object of reducing the corrosion of a reactor and the thermal decomposition of raw materials, as well as provides the effect of improving the reaction rate and nitrile selectivity.
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公开(公告)号：US20200291435A1
公开(公告)日：2020-09-17
申请号：US16766979
申请日：2018-11-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: Disclosed is a genetically modified microorganism into which a nucleic acid encoding an enzyme that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA is introduced. In the genetically modified microorganism, a nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or expression of the polypeptide is enhanced: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 6 and 213, (b) a polypeptide composed of the same amino acid sequence as any one of the amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, and/or added, and having enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, and (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of the amino acid sequences and having activity to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.
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公开(公告)号：US20180223318A1
公开(公告)日：2018-08-09
申请号：US15580585
申请日：2016-06-09
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Masateru ITO , Katsushige YAMADA
IPC: C12P7/44
CPC classification number: C12P7/44
Abstract: A method of producing α-hydromuconic acid using a metabolic pathway of a microorganism is disclosed. The method of producing α-hydromuconic acid includes the step of culturing at least one type of microorganism having a capacity to produce α-hydromuconic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Delftia, and microorganisms belonging to the genus Shimwellia.
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公开(公告)号：US20230101086A1
公开(公告)日：2023-03-30
申请号：US17908059
申请日：2021-03-17
Applicant: TORAY INDUSTRIES, INC.
Inventor： Kyohei ISOBE , Kenji KAWAMURA , Katsushige YAMADA
Abstract: A genetically modified microorganism that can produce 3-hydroxyadipic acid and/or α-hydromuconic acid with a high yield; and a method of producing 3-hydroxyadipic acid and/or α-hydromuconic acid using the genetically modified microorganism, are disclosed. The genetically modified microorganism has an ability to produce 3-hydroxyadipic acid and/or α-hydromuconic acid, and has an enhanced enzymatic activity to catalyze a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, wherein, in the genetically modified microorganism, a dicarboxylic acid excretion carrier function is deleted or decreased.
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公开(公告)号：US20210388410A1
公开(公告)日：2021-12-16
申请号：US17283299
申请日：2019-10-10
Applicant: Toray Industries, Inc.
Inventor： Yusuke KAGAWA , Shingo HIRAMATSU , Katsushige YAMADA
Abstract: A mutant strain of Trichoderma reesei has a mutation that eliminates or reduces a function of a polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 8, in which the mutation may be a mutation in which an aspartic acid residue at the 1,790 residue from the N-terminal side in the polypeptide consisting of the amino acid sequence represented by SEQ ID NO: 8 is changed to a residue of an amino acid other than aspartic acid.
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