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    Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device
    2.
    发明授权
    Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device 有权
    用于优化与可植入医疗装置一起使用的多部位心脏起搏和感测配置的系统和方法

    公开(公告)号：US08209010B2

    公开(公告)日：2012-06-26

    申请号：US12703069

    申请日：2010-02-09

    申请人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Taraneh Ghaffari Farazi ,  Xiaoyi Min

    发明人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Taraneh Ghaffari Farazi ,  Xiaoyi Min

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36514 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3708

    摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, referred to herein as QuickStim, cardiac pacing configurations are optimized based on an assessment of hemodynamic benefit and device longevity. In another example, referred to herein as QuickSense, cardiac sensing configurations are optimized based on sensing profiles input by a clinician. Various virtual sensing channels are also described that provide for the multiplexing or gating of sensed signals. Anisotropic oversampling is also described.

    摘要翻译： 提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。 在一个例子中，本文称为QuickStim，基于对血液动力学益处和器械寿命的评估来优化心脏起搏配置。 在另一个例子中，本文称为QuickSense，基于由临床医生输入的感测曲线来优化心脏感测配置。 还描述了各种虚拟感测通道，其提供感测信号的复用或门控。 还描述了各向异性过采样。

    Closed-loop systems and methods for controlling neurostimulation based on far-field cardiac signals sensed by a spinal cord stimulation device
    6.
    发明授权
    Closed-loop systems and methods for controlling neurostimulation based on far-field cardiac signals sensed by a spinal cord stimulation device 有权
    基于由脊髓刺激装置感测到的远场心脏信号的闭环系统和用于控制神经刺激的方法

    公开(公告)号：US08983604B2

    公开(公告)日：2015-03-17

    申请号：US13838305

    申请日：2013-03-15

    申请人： Allen Keel ,  Stuart Rosenberg ,  Rupinder Bharmi ,  Kyungmoo Ryu ,  Edward Karst ,  Fujian Qu ,  Xiaoyi Min ,  Yelena Nabutovsky

    发明人： Allen Keel ,  Stuart Rosenberg ,  Rupinder Bharmi ,  Kyungmoo Ryu ,  Edward Karst ,  Fujian Qu ,  Xiaoyi Min ,  Yelena Nabutovsky

    IPC分类号： A61N1/365 ,  A61N1/36

    CPC分类号： A61N1/36114 ,  A61N1/36139

    摘要： Techniques are provided for controlling spinal cord stimulation (SCS) or other forms of neurostimulation. Far-field cardiac electrical signals are sensed using a lead of the SCS device and neurostimulation is selectively delivering using a set of adjustable SCS control parameters. Parameters representative of cardiac rhythm are derived from the far-field cardiac electrical signals. The parameters representative of cardiac rhythm are correlated with SCS control parameters to thereby map neurostimulation control settings to cardiac rhythm parameters. The delivery of further neurostimulation is then controlled based on the mapping of neurostimulation control settings to cardiac rhythm parameters to, for example, address any cardiovascular disorders detected based on the far-field cardiac signals. In this manner, a closed loop control system is provided to automatically adjust SCS control parameters to respond to changes in cardiac rhythm such as changes associated with ischemia, arrhythmia or heart failure.

    摘要翻译： 提供了用于控制脊髓刺激（SCS）或其他形式的神经刺激的技术。 使用SCS装置的引线感测远场心电信号，并且神经刺激使用一组可调节的SCS控制参数选择性地递送。 代表心律的参数来源于远场心电信号。 代表心律的参数与SCS控制参数相关，从而将神经刺激控制设置映射到心律参数。 然后基于神经刺激控制设置对心律参数的映射来控制进一步的神经刺激的传递，以例如解决基于远场心脏信号检测的任何心血管疾病。 以这种方式，提供闭环控制系统以自动调整SCS控制参数以响应心律的变化，例如与缺血，心律失常或心力衰竭相关的变化。

    Multi-site pacing for atrial tachyarrhythmias
    7.
    发明授权
    Multi-site pacing for atrial tachyarrhythmias 有权
    多节段起搏用于房性快速性心律失常

    公开(公告)号：US07917216B1

    公开(公告)日：2011-03-29

    申请号：US11458649

    申请日：2006-07-19

    申请人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    发明人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3622 ,  A61N1/0587 ,  A61N1/3686

    摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.

    摘要翻译： 通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。 电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。 电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。 或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

    Multi-site pacing for atrial tachyarrhythmias
    8.
    发明授权
    Multi-site pacing for atrial tachyarrhythmias 有权
    多节段起搏用于房性快速性心律失常

    公开(公告)号：US08750993B2

    公开(公告)日：2014-06-10

    申请号：US13029048

    申请日：2011-02-16

    申请人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    发明人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    IPC分类号： A61N1/18

    CPC分类号： A61N1/3622 ,  A61N1/0587 ,  A61N1/3686

    摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.

    摘要翻译： 通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。 电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。 电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。 或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

    MULTI-SITE PACING FOR ATRIAL TACHYARRHYTHMIAS
    9.
    发明申请
    MULTI-SITE PACING FOR ATRIAL TACHYARRHYTHMIAS 有权
    多功能TACHYARRHYTHMIA的多地点

    公开(公告)号：US20110137364A1

    公开(公告)日：2011-06-09

    申请号：US13029048

    申请日：2011-02-16

    申请人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    发明人： Kyungmoo Ryu ,  Jong Gill ,  Xiaoyi Min ,  Annapurna Karicherla ,  Gene A. Bornzin

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3622 ,  A61N1/0587 ,  A61N1/3686

    摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria

    摘要翻译： 通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多部位电极组来治疗快速性心律失常。 电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。 电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。 或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组

    Systems and methods for optimizing AV/VV pacing delays using combined IEGM/impedance-based techniques for use with implantable medical devices
    10.
    发明授权
    Systems and methods for optimizing AV/VV pacing delays using combined IEGM/impedance-based techniques for use with implantable medical devices 有权
    使用组合的基于IEGM /阻抗的技术优化AV / VV起搏延迟的系统和方法，用于可植入医疗设备

    公开(公告)号：US08923965B2

    公开(公告)日：2014-12-30

    申请号：US12976322

    申请日：2010-12-22

    申请人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

    发明人： Xiaoyi Min ,  Gene A. Bornzin ,  Martin Cholette ,  Kyungmoo Ryu ,  Catherine Tan

    IPC分类号： A61B1/00 ,  A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/365 ,  A61N1/36521

    摘要： Systems and methods are provided wherein intracardiac electrogram (IEGM) signals are used to determine a set of preliminary optimized atrioventricular (AV/PV) and interventricular (VV) pacing delays. In one example, the preliminary optimized AV/VV pacing delays are used as a starting point for further optimization based on impedance signals such as impedance signals detected between a superior vena cava (SVC) coil electrode and a device housing electrode, which are influenced by changes in stroke volume within the patient. Ventricular pacing is thereafter delivered using the AV/VV pacing delays optimized via impedance. In another example, parameters derived from IEGM signals are used to limit the scope of an impedance-based optimization search to reduce the number of pacing tests needed during impedance-based optimization. Biventricular and multi-site left ventricular (MSLV) examples are described.

    摘要翻译： 提供了系统和方法，其中使用心内电描记图（IEGM）信号来确定一组初步优化的房室（AV / PV）和心室间（VV）起搏延迟。 在一个示例中，使用初步优化的AV / VV起搏延迟作为进一步优化的起点，其基于阻抗信号，例如在上腔静电（SVC）线圈电极和器件壳体电极之间检测到的阻抗信号，其受 患者体内搏动量的变化。 此后，使用通过阻抗优化的AV / VV起搏延迟来递送心室起搏。 在另一个示例中，从IEGM信号导出的参数用于限制基于阻抗的优化搜索的范围，以减少基于阻抗的优化期间所需的起搏测试次数。 描述了双心室和多部位左心室（MSLV）的例子。