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公开(公告)号：US09335326B2
公开(公告)日：2016-05-10
申请号：US14283638
申请日：2014-05-21
IPC分类号： G01N33/53 , G01N33/573 , G01N33/564
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/902 , G01N2333/904 , G01N2800/10
摘要： The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
摘要翻译： 本发明提供组合物，方法和试剂盒，诊断，监测和表征肌病，并用于检测生物样品中自身抗体的存在。
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公开(公告)号：US20160305941A1
公开(公告)日：2016-10-20
申请号：US15143728
申请日：2016-05-02
IPC分类号： G01N33/573 , G01N33/564 , A61K31/573
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/902 , G01N2333/904 , G01N2800/10
摘要： The invention provides compositions, methods, and kits for diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
摘要翻译： 本发明提供用于诊断，监测和表征肌病并用于检测生物样品中自身抗体的存在的组合物，方法和试剂盒。
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公开(公告)号：US09506924B2
公开(公告)日：2016-11-29
申请号：US15143728
申请日：2016-05-02
IPC分类号： G01N33/573 , G01N33/564
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/902 , G01N2333/904 , G01N2800/10
摘要： The invention provides compositions, methods, and kits for diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
摘要翻译： 本发明提供用于诊断，监测和表征肌病并用于检测生物样品中自身抗体的存在的组合物，方法和试剂盒。
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公开(公告)号：US20240241118A1
公开(公告)日：2024-07-18
申请号：US18289332
申请日：2022-01-24
IPC分类号： G01N33/564 , C12Q1/6841 , C12Q1/6851 , C12Q1/6883
CPC分类号： G01N33/564 , C12Q1/6883 , C12Q1/6841 , C12Q1/6851 , G01N2800/12 , G01N2800/24
摘要： Provided herein are methods of identifying a disease in a subject that include: (a) providing a biological sample from a subject; and (b) detecting an autoantibody that targets an antigen present in a telomerase/shelterin complex in the biological sample, thereby identifying a disease in the subject.
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5.发明公开公开(公告)号：US20240069023A1
公开(公告)日：2024-02-29
申请号：US18030465
申请日：2021-10-12
IPC分类号： G01N33/569 , G01N33/564 , G01N33/543
CPC分类号： G01N33/56983 , G01N33/564 , G01N33/54388 , G01N2333/165 , G01N2333/948 , G01N2469/10
摘要： Provided herein are methods for diagnosing the probability of extended duration of severe COVID19 symptoms in a subject infected with a SARS-CoV2 virus or suspected of being infected with the SARS-CoV2 virus, the method including (a) providing a biological sample from the subject; and (b) detecting the presence of an anti-ACE2 IgM antibody in the biological sample, thereby diagnosing the probability of extended duration of severe COVID19 symptoms in the subject.
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公开(公告)号：US20240302367A1
公开(公告)日：2024-09-12
申请号：US18573224
申请日：2022-06-07
IPC分类号： G01N33/564 , A61K39/00 , C07K16/18 , G01N33/574
CPC分类号： G01N33/564 , C07K16/18 , G01N33/57484 , A61K2039/505 , G01N2800/20 , G01N2800/50
摘要： This document relates to materials and methods for assessing and/or treating mammals (e.g., humans having autoimmune diseases). For example, materials and methods for determining if a mammal (e.g., a human having an autoimmune disease) has one or more antibodies that can be used to identify the mammal as having a lower risk of cancer or as having a higher risk of cancer are provided. Materials and methods for treating a mammal (e.g., a human) identified as having a higher cancer risk for cancer are also provided.
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公开(公告)号：US20210100882A1
公开(公告)日：2021-04-08
申请号：US17077661
申请日：2020-10-22
发明人： Erika Darrah , Ami A. Shah , Livia A. Casciola-Rosen , Antony Rosen , Christine Joseph , Bert Vogelstein , Kenneth W. Kinzler , Nickolas Papadopoulos
IPC分类号： A61K39/00
摘要： Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses. Acquired immunity to autoimmune antigens can help control naturally occurring cancers.
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公开(公告)号：US20160303209A1
公开(公告)日：2016-10-20
申请号：US15101174
申请日：2014-12-04
发明人： Erika Darrah , Ami A. Shah , Livia A. Casciola-Rosen , Anthony Rosen , Christine Joseph , Bert Vogelstein , Kenneth W. Kinzler , Nickolas Papadopoulos
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K38/00 , A61K2039/585
摘要： Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses. Acquired immunity to autoimmune antigens can help control naturally occurring cancers.
摘要翻译： 自身免疫性疾病被认为是通过暴露于与内源性分子交叉反应的外来抗原来引发的。 外周血淋巴细胞和血清的分析表明，自身免疫抗原靶突变引发细胞免疫和交叉反应性体液免疫应答。 对自身免疫性抗原的获得性免疫可以帮助控制天然存在的癌症。
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公开(公告)号：US20140377784A1
公开(公告)日：2014-12-25
申请号：US14283638
申请日：2014-05-21
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/902 , G01N2333/904 , G01N2800/10
摘要： The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
摘要翻译： 本发明提供组合物，方法和试剂盒，诊断，监测和表征肌病，并用于检测生物样品中自身抗体的存在。
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