公开(公告)号：US20140328956A1

公开(公告)日：2014-11-06

申请号：US14334036

申请日：2014-07-17

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Kent J. Johnson

IPC: A61K31/12 ,  A61K36/9066 ,  A61K36/9068

CPC classification number: A61K31/12 ,  A61K8/35 ,  A61K9/0014 ,  A61K31/56 ,  A61K36/9066 ,  A61K36/9068 ,  A61K45/06 ,  A61K47/10 ,  A61K2800/592 ,  A61Q19/08 ,  A61K2300/00

Abstract: A skin augmentation composition comprises a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier. Methods for enhancing the repair of damaged skin and the prevention of developing wounds in a subject having damaged skin comprises administering to a portion of damaged skin, a composition comprising a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier.

Abstract translation: 皮肤增强组合物包含治疗有效量的姜油和姜黄素以及化妆品或药学上可接受的载体的组合。 用于增强受损皮肤修复和预防受损皮肤受试者的伤口的方法包括对受损皮肤的一部分施用包含治疗有效量的姜红素和姜黄素以及化妆品或药学上的组合的组合物 可接受的载体

公开(公告)号：US20180008557A1

公开(公告)日：2018-01-11

申请号：US15710194

申请日：2017-09-20

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Kent J. Johnson

IPC: A61K31/12 ,  A61K36/9068 ,  A61K47/10 ,  A61K9/00 ,  A61K8/35 ,  A61K36/9066 ,  A61K31/56 ,  A61Q19/08 ,  A61K45/06

CPC classification number: A61K31/12 ,  A61K8/35 ,  A61K9/0014 ,  A61K31/56 ,  A61K36/9066 ,  A61K36/9068 ,  A61K45/06 ,  A61K47/10 ,  A61K2800/592 ,  A61Q19/08 ,  A61K2300/00

Abstract: A skin augmentation composition comprises a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier. Methods for enhancing the repair of damaged skin and the prevention of developing wounds in a subject having damaged skin comprises administering to a portion of damaged skin, a composition comprising a therapeutically effective amount of a combination of a gingerol and a curcumin and a cosmetically or pharmaceutically acceptable carrier.

公开(公告)号：US11148998B2

公开(公告)日：2021-10-19

申请号：US15987274

申请日：2018-05-23

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Hollis Showalter ,  Andy White ,  Kent J. Johnson

IPC: A61K45/06 ,  C07C235/30 ,  C07D209/54 ,  C07D305/06 ,  C07C233/50 ,  C07C233/31 ,  C07D211/74 ,  C07D207/24 ,  A61P17/10 ,  A61P17/06 ,  A61P35/02 ,  A61P17/02

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a dimethyl-nonatetraenyl-trimethyl-cyclohexyl structure useful as therapeutics for the treatment of subjects suffering from disorders characterized by abnormal proliferation and/or abnormal differentiation of cells, in particular of cells of which the growth and differentiation is sensitive to the actions of retinoids.

公开(公告)号：US20180339961A1

公开(公告)日：2018-11-29

申请号：US15987274

申请日：2018-05-23

Applicant: The Regents of the University of Michigan

Inventor： James Varani ,  Hollis Showalter ,  Andy White ,  Kent J. Johnson

IPC: C07C235/30 ,  A61P17/02 ,  A61P17/10 ,  A61P17/06 ,  A61P35/02

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a dimethyl-nonatetraenyl-trimethyl-cyclohexyl structure useful as therapeutics for the treatment of subjects suffering from disorders characterized by abnormal proliferation and/or abnormal differentiation of cells, in particular of cells of which the growth and differentiation is sensitive to the actions of retinoids.