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公开(公告)号：US06214826B1
公开(公告)日：2001-04-10
申请号：US09365562
申请日：1999-08-02
申请人： Thomas Michael Bare , Marc Jerome Chapdelaine , Timothy Wayne Davenport , James Roy Empfield , Laura Enid Garcia-Davenport , Paul Francis Jackson , Jeffrey Alan McKinney , Charles David McLaren , Richard Bruce Sparks
发明人： Thomas Michael Bare , Marc Jerome Chapdelaine , Timothy Wayne Davenport , James Roy Empfield , Laura Enid Garcia-Davenport , Paul Francis Jackson , Jeffrey Alan McKinney , Charles David McLaren , Richard Bruce Sparks
IPC分类号： A61K315025
CPC分类号： C07D471/04
摘要： The invention relates to pyridazinoquinoline compounds of the formulas B and B′ wherein Ring A is selected from an ortho fused aromatic or heteroaromatic five- or six-membered ring and R1, R3 and R4 are substituents selected from halo, OH, OCF3, NO2, CN, NR′R″, SO2NR′R″, SOmR′alkyl, and a variety of alkyl, aryl, heterocyclic and heteroaryl groups, to pharmaceutical compositions containing them and to methods utilizing them for the treatment of neurological disorders.
摘要翻译： 本发明涉及式B和B'的哒嗪喹啉化合物，其中环A选自邻稠合芳族或杂芳族五元或六元环，且R 1，R 3和R 4为选自卤素，OH，OCF 3，NO 2， CN，NR'R“，SO2NR'R”，SOmR'烷基，以及各种烷基，芳基，杂环和杂芳基，含有它们的药物组合物以及利用它们用于治疗神经障碍的方法。
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公开(公告)号：US06232313B1
公开(公告)日：2001-05-15
申请号：US09044109
申请日：1998-03-19
申请人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
发明人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
IPC分类号： A61K315025
CPC分类号： C07D471/04 , C07D215/56
摘要： The present invention relates to compounds, pharmaceutical compositions and methods of using compounds having the formula below in the treatment and prevention of certain diseases or conditions. Where the ring designated A is chosen from ortho substituted aryl or heteroaryl species, R1 and R2 are chosen independently from —(CH2)nL where L is selected from a variety of substituents including hydrogen, and aryl, heteroaryl or heterocyclic groups and R4 is chosen from a variety of substituents including halogen and alkyl groups. The compounds are useful in treating and preventing neurological disorders associated with excitatory amino acids.
摘要翻译： 本发明涉及在治疗和预防某些疾病或病症时使用具有下式的化合物的化合物，药物组合物和方法。 当指定为A的环选自邻位取代的芳基或杂芳基时，R 1和R 2独立地选自 - （CH 2）n L，其中L选自多种取代基，包括氢和芳基，杂芳基或杂环基，并且选择R4 来自各种取代基，包括卤素和烷基。 该化合物可用于治疗和预防与兴奋性氨基酸相关的神经障碍。
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公开(公告)号：US6103721A
公开(公告)日：2000-08-15
申请号：US455096
申请日：1999-12-06
申请人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
发明人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
IPC分类号： A61K31/50 , A61K31/5025 , A61P3/08 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07D215/56 , C07D221/00 , C07D221/04 , C07D237/00 , C07D471/04 , C07D471/14 , C07D495/14
CPC分类号： C07D471/04 , C07D215/56
摘要： The present invention concerns compounds according to the following formula, ##STR1## wherein: R.sup.1 is (CH.sub.2).sub.n,L where n is an integer in the range 0 to 6, and L is a carbon-linked five-membered heteroaryl ring having an oxygen or sulfur heteroatom, R.sup.4 is hydrogen, halo or NO.sub.2, and pharmaceutical compositions and methods of using thereof in the treatment and/or prevention of neurological diseases or conditions.
摘要翻译： 本发明涉及根据下式的化合物，其中：R1是（CH2）n，L，其中n是0-6的整数，L是具有氧或硫的碳连接的五元杂芳基环 杂原子，R4是氢，卤素或NO2，以及其用于治疗和/或预防神经疾病或病症的药物组合物和方法。
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公开(公告)号：US5744471A
公开(公告)日：1998-04-28
申请号：US637641
申请日：1996-04-17
申请人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
发明人： Thomas Michael Bare , Timothy Wayne Davenport , James Roy Empfield , Jeffrey Alan McKinney , Richard Bruce Sparks
IPC分类号： A61K31/50 , A61K31/5025 , A61P3/08 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/28 , A61P43/00 , C07D215/56 , C07D221/00 , C07D221/04 , C07D237/00 , C07D471/04 , C07D471/14 , C07D495/14 , C07D491/14
CPC分类号： C07D471/04 , C07D215/56
摘要： The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula (I) in the treatment and/or prevention of certain diseases or conditions. In formula (I), A is chosen from ortho substituted aryl or heteroaryl species, X is chosen from --OH, --SH, NHR and R.sup.1 or R.sup.2 is chosen from --(CH.sub.2).sub.n L wherein L may be selected from a variety of substituents including aryl, heteroaryl and heterocyclic groups. The compounds are useful in treating and/or preventing neurological disorders associated with excitatory amino acids. ##STR1##
摘要翻译： PCT No.PCT / GB94 / 02295 371日期：1996年4月17日 102（e）日期1996年4月17日PCT 1994年10月20日PCT公布。 出版物WO95 / 11244 日期1995年04月27日本发明涉及使用式（I）化合物治疗和/或预防某些疾病或病症的化合物，药物组合物和方法。 在式（I）中，A选自邻位取代的芳基或杂芳基，X选自-OH，-SH，NHR，R 1或R 2选自 - （CH 2）n L，其中L可以选自多种取代基 包括芳基，杂芳基和杂环基。 该化合物可用于治疗和/或预防与兴奋性氨基酸相关的神经障碍。
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5.发明申请Composition and methods for amelioration of diseases and related symptoms in domestic animals 审中-公开用于改善家畜疾病和相关症状的组合物和方法公开(公告)号：US20150313941A1
公开(公告)日：2015-11-05
申请号：US14545289
申请日：2015-04-17
IPC分类号： A61K33/30 , A61K31/375 , A61K31/355 , A61K36/45 , A61K31/047 , A61K36/07 , A61K31/385 , A61K36/752 , A61K36/185 , A61K36/22 , A61K36/87 , A61K36/73 , A61K31/07 , A61K31/353
CPC分类号： A61K31/375 , A23L33/10 , A61K31/047 , A61K31/07 , A61K31/202 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/357 , A61K31/385 , A61K31/7008 , A61K33/00 , A61K33/30 , A61K36/07 , A61K36/185 , A61K36/21 , A61K36/22 , A61K36/23 , A61K36/31 , A61K36/45 , A61K36/73 , A61K36/752 , A61K36/81 , A61K36/87 , A61K36/88 , A61K2300/00
摘要： The present invention is generally directed to compositions and methods for amelioration of diseases and related symptoms in domestic animals. In one aspect, the invention is directed to a method of ameliorating the symptoms of arthritis, brain aging, cataracts, diabetes, dermatitis, FLUTD, glaucoma, low energy levels or obesity in a domestic animal, wherein the method comprises administering a composition to the animal, wherein the composition comprises a Fruit-Based Additive, a Vegetable-Based Additive or a Fruit- and Vegetable-Based Additive.
摘要翻译： 本发明一般涉及在家畜中改善疾病和相关症状的组合物和方法。 一方面，本发明涉及一种改善家畜的关节炎，脑衰老，白内障，糖尿病，皮炎，FLUTD，青光眼，低能量水平或肥胖的症状的方法，其中所述方法包括将组合物施用于 动物，其中所述组合物包含基于水果的添加剂，基于蔬菜的添加剂或基于水果和蔬菜的添加剂。
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公开(公告)号：US20240294453A1
公开(公告)日：2024-09-05
申请号：US18445729
申请日：2024-01-02
CPC分类号： C07C39/23 , C07B59/001 , C07B2200/05 , C07C2601/16
摘要： The present invention is generally directed to deuterated agonists and their methods of use. It is more specifically directed to deuterated alpha-7 nicotinic receptor agonists and their methods of use. In one aspect, the present invention involves compounds of the structure 1-34 as shown in FIGS. 1-4. In another aspect, the present invention involves the treatment of a disorder with a compound of the structure 1-34 as shown in FIGS. 1-4.
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公开(公告)号：US20210371423A1
公开(公告)日：2021-12-02
申请号：US17300293
申请日：2021-05-13
IPC分类号： C07D471/18
摘要： The present invention relates to Ibogaine derivatives and related methods. It more specifically relates to deutero- and fluoro-derivatives of Ibogaine and related methods. In one aspect, the present invention provides a compound. The structure of the compound is shown as compound 1 in FIG. 1. In another aspect, the present invention provides a method of treating an addiction disorder. The method comprises administration of compound 1. In another aspect, the present invention provides a method of treating an anxiety-related disorder or impulse control disorder. The method comprises administration of compound 1.
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公开(公告)号：US11680066B2
公开(公告)日：2023-06-20
申请号：US17300293
申请日：2021-05-13
IPC分类号： A61K31/55 , A61P25/22 , A61P25/30 , C07D471/18
CPC分类号： C07D471/18 , C07B2200/05
摘要： The present invention relates to Ibogaine derivatives and related methods. It more specifically relates to deutero- and fluoro-derivatives of Ibogaine and related methods. In one aspect, the present invention provides a compound. The structure of the compound is shown as compound 1 in FIG. 1. In another aspect, the present invention provides a method of treating an addiction disorder. The method comprises administration of compound 1. In another aspect, the present invention provides a method of treating an anxiety-related disorder or impulse control disorder. The method comprises administration of compound 1.
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9.发明申请Compositions and methods for amelioration of chronic renal failure and related symptoms in domestic animals 审中-公开用于改善家畜的慢性肾功能衰竭和相关症状的组合物和方法公开(公告)号：US20140322358A1
公开(公告)日：2014-10-30
申请号：US14120103
申请日：2014-04-24
IPC分类号： A61K33/14 , A61K36/45 , A61K36/73 , A61K36/752 , A61K36/21 , A61K36/87 , A61K36/31 , A61K36/23 , A61K36/06 , A61K36/81 , A61K36/18
CPC分类号： A61K33/14 , A61K31/722 , A61K33/00 , A61K33/10 , A61K33/24 , A61K36/07 , A61K36/21 , A61K36/23 , A61K36/31 , A61K36/45 , A61K36/73 , A61K36/752 , A61K36/81 , A61K36/87 , A61K45/06 , A61K2300/00
摘要： The present invention is generally directed to compositions and methods for amelioration chronic renal failure and related symptoms in domestic animals. In one case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Fruit- and Vegetable-Based Additive. In another case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Cesium and/or Rubidium salt. In another case, the present invention is directed to a composition for the treatment of chronic renal failure in a domestic animal or symptoms related to chronic renal failure. The composition comprises a Dehydrated Domestic Animal Food and a Phosphate Binder.
摘要翻译： 本发明一般涉及用于改善家畜的慢性肾功能衰竭和相关症状的组合物和方法。 在一种情况下，本发明涉及用于治疗家畜中慢性肾功能衰竭的组合物或与慢性肾功能衰竭有关的症状。 该组合物包括基于水果和蔬菜的添加剂。 在另一种情况下，本发明涉及用于治疗家畜中慢性肾功能衰竭的组合物或与慢性肾功能衰竭有关的症状。 组合物包含铯和/或铷盐。 在另一种情况下，本发明涉及用于治疗家畜中慢性肾功能衰竭的组合物或与慢性肾功能衰竭有关的症状。 该组合物包含脱水的家畜饲料和磷酸盐粘合剂。
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公开(公告)号：US20230303571A1
公开(公告)日：2023-09-28
申请号：US18445155
申请日：2023-05-01
IPC分类号： C07D471/18
CPC分类号： C07D471/18 , C07B2200/05
摘要： The present invention relates to Ibogaine derivatives and related methods. It more specifically relates to deutero- and fluoro-derivatives of Ibogaine and related methods. In one aspect, the present invention provides a compound. The structure of the compound is shown as compound 1 in FIG. 1. In another aspect, the present invention provides a method of treating an addiction disorder. The method comprises administration of compound 1. In another aspect, the present invention provides a method of treating an anxiety-related disorder or impulse control disorder. The method comprises administration of compound 1.
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