公开(公告)号：US20050151090A1

公开(公告)日：2005-07-14

申请号：US11015190

申请日：2004-12-16

申请人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

发明人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC分类号： H01J49/04 ,  H01J49/16 ,  H01J27/00

CPC分类号： H01J49/164 ,  H01J49/0477

摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

摘要翻译： 本发明涉及一种与质谱仪一起使用的装置和方法。 本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。 离子增强系统介于离子源和检测器之间。 接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。 本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。

公开(公告)号：US07135689B2

公开(公告)日：2006-11-14

申请号：US11041118

申请日：2005-01-21

申请人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

发明人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC分类号： H01J27/00

CPC分类号： H01J49/164 ,  H01J49/0477

摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US20050161613A1

公开(公告)日：2005-07-28

申请号：US11041118

申请日：2005-01-21

申请人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

发明人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC分类号： H01J49/04 ,  H01J49/16 ,  H01J27/00

CPC分类号： H01J49/164 ,  H01J49/0477

摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US07132670B2

公开(公告)日：2006-11-07

申请号：US11015190

申请日：2004-12-16

申请人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

发明人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC分类号： H01J27/00

CPC分类号： H01J49/164 ,  H01J49/0477

摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US20050274905A1

公开(公告)日：2005-12-15

申请号：US11155070

申请日：2005-06-16

申请人： Timothy Joyce ,  Jean-Luc Truche ,  Jian Bai

发明人： Timothy Joyce ,  Jean-Luc Truche ,  Jian Bai

IPC分类号： H01J27/00 ,  H01J49/16

CPC分类号： H01J49/164 ,  H01J49/0422 ,  H01J49/0477 ,  H01J49/0486

摘要： The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.

摘要翻译： 本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。 离子源还可以包括温度传感器。 加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。 还公开了具有基于基质的离子源的质谱仪系统。 还提供了使用被加热到预定温度的气体产生离子的方法。

公开(公告)号：US20050151091A1

公开(公告)日：2005-07-14

申请号：US11015191

申请日：2004-12-16

申请人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

发明人： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC分类号： H01J49/04 ,  H01J49/16 ,  H01J27/00

CPC分类号： H01J49/164 ,  H01J49/0477

摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US20070001114A1

公开(公告)日：2007-01-04

申请号：US11172217

申请日：2005-06-29

申请人： Paul Goodley ,  Jean-Luc Truche ,  Jerry Dowell ,  Timothy Joyce

发明人： Paul Goodley ,  Jean-Luc Truche ,  Jerry Dowell ,  Timothy Joyce

IPC分类号： H01J49/10

CPC分类号： H01J49/0418

摘要： The present invention relates to an apparatus and method for producing ions. The apparatus may be used separately as an ion source or in combination with a mass spectrometry system. The ion source of the present invention provides an ionization device for producing ions, a substrate for capturing, storing and releasing ions produced by the ionization device, a conductive material in contact with the substrate for receiving an electrical pulse, and a voltage source electrically connected to the conductive material for applying an electrical pulse to the conductive material and substrate to release the ions captured by the substrate. Also disclosed is a method for storing and releasing ions using the disclosed apparatus.

摘要翻译： 本发明涉及一种用于生产离子的装置和方法。 该装置可以单独用作离子源或与质谱系统组合使用。 本发明的离子源提供用于产生离子的离子化装置，用于捕获，存储和释放由离子化装置产生的离子的基板，与基板接触的用于接收电脉冲的导电材料和电连接的电压源 涉及用于将电脉冲施加到导电材料和衬底以释放由衬底捕获的离子的导电材料。 还公开了使用所公开的装置来存储和释放离子的方法。

公开(公告)号：US20060097149A1

公开(公告)日：2006-05-11

申请号：US10971164

申请日：2004-10-22

申请人： Timothy Joyce

发明人： Timothy Joyce

IPC分类号： H01J49/00

CPC分类号： H01J49/164 ,  H01J49/0418

摘要： The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a nanowire target substrate for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.

摘要翻译： 本发明提供一种生成分析物离子以供检测器检测的装置。 该装置包括具有用于产生分析物离子的纳米线靶基质的基于基质的离子源，与基于基质的离子源相邻的离子传输系统，用于将基于离子源的离子源输送到分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。 本发明还提供了一种用于产生和检测分析物离子的方法。

公开(公告)号：US20060081775A1

公开(公告)日：2006-04-20

申请号：US10966191

申请日：2004-10-15

申请人： Timothy Joyce ,  Jennifer Lu

发明人： Timothy Joyce ,  Jennifer Lu

IPC分类号： H01J49/10

CPC分类号： H01J49/147 ,  B82Y10/00

摘要： An ionization chamber for a mass spectrometry system is described. The ionization chamber comprises a housing defining an ionization region, and the housing comprises a carbon nanotube material.

公开(公告)号：US20060019259A1

公开(公告)日：2006-01-26

申请号：US10898586

申请日：2004-07-22

申请人： Timothy Joyce

发明人： Timothy Joyce

IPC分类号： C12Q1/68 ,  C12M3/04

CPC分类号： G01N33/6818 ,  C12Q1/6869 ,  G01N33/48721 ,  C12Q2565/631 ,  C12Q2565/607

摘要： The present invention provides a method and apparatus for determining the identity of a monomeric residue of a biopolymer. The apparatus comprises a substrate having a nanopore, a potential-producing element for producing a ramped potential across electrodes adjacent to the nanopore, and a quenchable excitable moiety adjacent to the nanopore. As a biopolymer passes through the nanopore, the identity of monomeric residues of a biopolymer may be determined by detecting changes in (a) current across the electrodes and (b) a signal of the quenchable excitable molecule. The subject method and apparatus find use in determining the identity of a plurality of monomeric residues of a biopolymer, and, as such, may be employed in a variety of diagnostic and research applications.

摘要翻译： 本发明提供了用于测定生物聚合物的单体残基的身份的方法和装置。 该装置包括具有纳米孔的底物，用于在邻近纳米孔的电极之间产生斜坡电位的潜在产生元件和与该纳米孔相邻的可淬火的可兴奋部分。 当生物聚合物通过纳米孔时，生物聚合物的单体残基的身份可以通过检测（a）跨越电极的电流的变化和（b）可淬灭的可激发分子的信号来确定。 本发明的方法和装置用于确定生物聚合物的多个单体残基的身份，并且因此可用于多种诊断和研究应用。