公开(公告)号：US07132670B2

公开(公告)日：2006-11-07

申请号：US11015190

申请日：2004-12-16

Applicant: Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

Inventor： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC: H01J27/00

CPC classification number: H01J49/164 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US20050274905A1

公开(公告)日：2005-12-15

申请号：US11155070

申请日：2005-06-16

Applicant: Timothy Joyce ,  Jean-Luc Truche ,  Jian Bai

Inventor： Timothy Joyce ,  Jean-Luc Truche ,  Jian Bai

IPC: H01J27/00 ,  H01J49/16

CPC classification number: H01J49/164 ,  H01J49/0422 ,  H01J49/0477 ,  H01J49/0486

Abstract: The invention described herein provides a matrix-based ion source including a gas heating device for providing heated gas at a defined temperature to the ionization region of the ion source. The ion source may also include a temperature sensor. The heating device and temperature sensor may be operably connected to work as a closed feedback loop to provide gas at a constant, pre-determined, temperature to the ionization region. Also disclosed is a mass spectrometer system having the matrix-based ion source. A method of producing ions employing gas that is heated to a pre-determined temperature is also provided.

Abstract translation: 本文描述的本发明提供了一种基于矩阵的离子源，其包括用于在限定的温度下向离子源的电离区域提供加热气体的气体加热装置。 离子源还可以包括温度传感器。 加热装置和温度传感器可以可操作地连接以作为闭合反馈回路工作，以将恒定的预定温度的气体提供给电离区域。 还公开了具有基于基质的离子源的质谱仪系统。 还提供了使用被加热到预定温度的气体产生离子的方法。

公开(公告)号：US4804839A

公开(公告)日：1989-02-14

申请号：US070458

申请日：1987-07-07

Applicant: Carolyn C. Broadbent ,  John C. Fjeldsted

Inventor： Carolyn C. Broadbent ,  John C. Fjeldsted

IPC: G01N27/62 ,  G01N30/30 ,  G01N30/72 ,  H01J49/04

CPC classification number: H01J49/0477 ,  G01N30/7206 ,  G01N2030/3015

Abstract: In a gas chromatograph/mass spectrometer (GC/MS) instrument, an improved heating system includes an interface between the gas chromatograph and mass spectrometer portions of the instrument, a radiator located within a vacuum chamber of the mass spectrometer, a thermal coupler attaching the interface to the radiator, and a heat source which directly heats the interface and indirectly heats the radiator via conduction through the thermal coupler. The heating system uses a single heating element located externally to the vacuum system of the mass spectrometer to produce a multiplicity of temperatures for the interface and various portions of the mass spectrometer.

公开(公告)号：US20160086784A1

公开(公告)日：2016-03-24

申请号：US14826388

申请日：2015-08-14

Applicant: Bruker Daltonik GmbH

Inventor： Andreas BREKENFELD ,  Martin ENGEL

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0486 ,  C03B19/12 ,  C04B35/14 ,  H01J49/0422 ,  H01J49/044 ,  H01J49/045 ,  H01J49/0477 ,  H01J49/10 ,  Y02P40/57

Abstract: The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material.

Abstract translation: 本发明涉及一种用于连接到质谱仪的电离室。 电离室具有温度控制块，其具有气体入口和气体通道，其从气体入口开始并导入气体出口。 温度控制装置沿着气体通道定位，并且确保在气体通道中流动的气体在进入电离室之前被带到特定温度，即被加热或冷却。 温度控制块具有形成部分，其中结合有气体通道的结构，并且其通过溶胶 - 凝胶法制造，例如由玻璃或陶瓷材料制成。

公开(公告)号：US20050072918A1

公开(公告)日：2005-04-07

申请号：US10966278

申请日：2004-10-15

Applicant: Jean-Luc Truche ,  Jian Bal

Inventor： Jean-Luc Truche ,  Jian Bal

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/00

CPC classification number: H01J49/164 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US06593568B1

公开(公告)日：2003-07-15

申请号：US09324401

申请日：1999-06-02

Applicant: Craig M. Whitehouse ,  Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Clement Catalano

Inventor： Craig M. Whitehouse ,  Bruce A. Andrien, Jr. ,  Michael A. Sansone ,  Clement Catalano

IPC: B01D5944

CPC classification number: H01J49/0477 ,  H01J49/0404 ,  H01J49/044

Abstract: An Atmospheric Pressure Ion (API) source is configured for Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) operating modes. The API source includes a multipurpose heater assembly mounted in the API source chamber. The multipurpose heater supplies heat to the API chamber endplate, bath gas and entrance end of the capillary orifice into vacuum as well as supplying electrical connections to the API source elements. An additional heater is configured at the exit end of the capillary orifice into vacuum. With this configuration, the bath gas, endplate and capillary entrance temperature can be set independent of gas flow rate. The capillary exit and entrance temperatures can be set independently as well. The multipurpose endplate heater combined with the capillary exit heater allows the optimization of API source performance over a wide range of operating conditions and analytical applications.

Abstract translation: 大气压离子（API）源被配置用于电喷雾（ES）和大气压化学电离（APCI）操作模式。 API源包括安装在API源室中的多用途加热器组件。 多功能加热器将API室端板，浴室气体和毛细孔入口端的热量提供到真空中，并向API源元件提供电气连接。 另外的加热器配置在毛细管孔的出口端进入真空。 通过这种配置，浴气，终板和毛细管入口温度可独立于气体流量设定。 毛细管出口和入口温度也可以独立设置。 多用途终板加热器与毛细管出口加热器相结合，可以在广泛的操作条件和分析应用中优化API源性能。

公开(公告)号：US20230420239A1

公开(公告)日：2023-12-28

申请号：US17960447

申请日：2022-10-05

Applicant: Shimadzu Corporation

Inventor： Keisuke ISO

IPC: H01J49/16 ,  H01J49/04 ,  G01N30/72

CPC classification number: H01J49/165 ,  H01J49/044 ,  H01J49/0477 ,  G01N30/7246

Abstract: In an ionization device for an ionization chamber (11) separated from an analysis chamber (12-14) by a partition wall having an ion introduction port (113), an ionization probe (111) sprays a liquid sample. A heated-gas supply mechanism (112), which includes a gas supply source and a heating section (1122) for heating a gas supplied from the gas supply source, expels the gas in a direction intersecting with the direction in which the liquid sample is sprayed from the ionization probe. A controller (32) controls an operation of the heated-gas supply mechanism so that the gas is continuously expelled from the heated-gas supply mechanism regardless of the presence or absence of an operation by a user while the liquid sample is sprayed from the ionization probe. The continuous expulsion of the gas from the heated-gas supply mechanism prevents this mechanism from being contaminated by the sprayed liquid.

公开(公告)号：US07091482B2

公开(公告)日：2006-08-15

申请号：US10966278

申请日：2004-10-15

Applicant: Jean-Luc Truche ,  Jian Bal

Inventor： Jean-Luc Truche ,  Jian Bal

IPC: H01J49/40 ,  H01J49/42 ,  H01J49/26

CPC classification number: H01J49/164 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

公开(公告)号：US20060131497A1

公开(公告)日：2006-06-22

申请号：US11015235

申请日：2004-12-17

Applicant: Zicheng Yang ,  Roger Tong

Inventor： Zicheng Yang ,  Roger Tong

IPC: H01J49/04

CPC classification number: H01J49/0477 ,  H01J49/044

Abstract: An apparatus for use in atmospheric pressure ionization includes a sample receiving chamber, a sample droplet source communicating with the sample receiving chamber, an outlet conduit, and a boundary. The outlet conduit defines a sampling orifice that communicates with the sample receiving chamber. The boundary is interposed between the sample receiving chamber and the sampling orifice and comprises an opening. The opening defines a first passage through which a drying gas is flowable into the sample receiving chamber in an elongated flow profile, and a second passage through which sample material is flowable from the sample receiving chamber toward the sampling orifice. The first passage is positioned in non-coaxial relation to the second passage. The first passage is configured to introduce the elongated flow profile of the drying gas into a pathway of droplets of the sample material flowing toward the second passage.

Abstract translation: 用于大气压离子化的装置包括样品接收室，与样品接收室连通的样品液滴源，出口导管和边界。 出口导管限定了与样品接收室连通的采样孔。 边界置于样品接收室和采样孔之间，并包括一个开口。 开口限定第一通道，干燥气体可以通过该第一通道以细长的流动分布流入样品接收室，以及第二通道，样品材料可以通过该第二通道从样品接收室朝向采样孔流动。 第一通道定位成与第二通道非同轴的关系。 第一通道构造成将干燥气体的细长流动剖面引入流向第二通道的样品材料液滴的通路。

公开(公告)号：US20050151090A1

公开(公告)日：2005-07-14

申请号：US11015190

申请日：2004-12-16

Applicant: Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

Inventor： Jean-Luc Truche ,  Jian Bai ,  Timothy Joyce

IPC: H01J49/04 ,  H01J49/16 ,  H01J27/00

CPC classification number: H01J49/164 ,  H01J49/0477

Abstract: The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

Abstract translation: 本发明涉及一种与质谱仪一起使用的装置和方法。 本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。 离子增强系统介于离子源和检测器之间。 接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。 本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。