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    Test plates for agglutination test and production process thereof
    1.
    发明授权
    Test plates for agglutination test and production process thereof 失效
    凝集试验用试验板及其制造方法

    公开(公告)号：US5736099A

    公开(公告)日：1998-04-07

    申请号：US579584

    申请日：1995-12-28

    申请人： Tsuneo Hiraide ,  Tetsuro Ogawa ,  Ayumi Mitoh ,  Tadahiko Kitano ,  Mikio Nakayama

    发明人： Tsuneo Hiraide ,  Tetsuro Ogawa ,  Ayumi Mitoh ,  Tadahiko Kitano ,  Mikio Nakayama

    IPC分类号： A61B5/00 ,  A61B5/15 ,  G01N33/543 ,  G01N33/53

    CPC分类号： G01N33/54366

    摘要： A test plate for an agglutination test which comprises a plate with a plurality of wells formed thereon, each of the wells having adhered to a surface thereof a protein A and/or a protein G. The agglutination test plate, according to the present invention, when used in an agglutination test, can ensure a clear judgment concerning the formation of an agglutinative image or a non-agglutinative image, along with a good determination sensitivity. A process for the production of such an agglutination test plate is also provided.

    摘要翻译： 一种用于凝集试验的试验板，其包括在其上形成有多个孔的板，每个孔的表面粘附有蛋白A和/或蛋白G.根据本发明的凝集试验板， 当用于凝集试验时，可以确保对凝集图像或非凝集图像的形成的清晰判断以及良好的测定灵敏度。 还提供了生产这种凝集试验板的方法。

    Sheets, kits and methods for detecting antigens or antibodies
    2.
    发明授权
    Sheets, kits and methods for detecting antigens or antibodies 失效
    用于检测抗原或抗体的片剂，试剂盒和方法

    公开(公告)号：US5827669A

    公开(公告)日：1998-10-27

    申请号：US746485

    申请日：1996-11-12

    申请人： Mikio Nakayama ,  Tadahiko Kitano ,  Ayumi Mitoh ,  Tetsuro Ogawa ,  Tsuneo Hiraide

    发明人： Mikio Nakayama ,  Tadahiko Kitano ,  Ayumi Mitoh ,  Tetsuro Ogawa ,  Tsuneo Hiraide

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/547 ,  G01N33/551

    CPC分类号： G01N33/54306 ,  G01N33/54313 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/808

    摘要： A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the detection sheet. The detection sheet comprises (a) a fibrous aggregate with carried particles of a calcium phosphate compound having an average particle diameter of about 0.01 to 200 microns and a Ca/P ratio of about 1.0 to 2.0, and (b) an avidin, streptavidin or avidin derivative from which carbohydrates have been extracted immobilized on said calcium phosphate compound. After a biotinylated antigen or antibody is bonded to the immobilized avidin, streptavidin, or avidin derivative of the detection sheet, the detection sheet is contacted with a test solution to thereby bond an antigen or antibody of the test solution to the detection sheet. The detection sheet is then contacted with a solution of labeling compound capable of being specifically bonded to the antigen or antibody of said test solution to detect the thus labeled antigen-antibody complex.

    摘要翻译： 能够在简单的操作中能够以高灵敏度检测生物流体中的抗原或抗体的检测片以及使用检测片的检测试剂盒和检测方法。 检测片包括（a）具有平均粒径为约0.01至200微米并且Ca / P比为约1.0至2.0的带有磷酸钙化合物的载体的纤维聚集体，和（b）抗生物素蛋白，链霉抗生物素蛋白或 提取固定在所述磷酸钙化合物上的碳水化合物的抗生物素蛋白衍生物。 将生物素化的抗原或抗体与检测片的固定化抗生物素蛋白，链亲和素或抗生物蛋白衍生物结合后，使检测片与测试溶液接触，从而将检测溶液的抗原或抗体与检测片结合。 然后将检测片与能够与所述测试溶液的抗原或抗体特异性结合的标记化合物溶液接触，以检测如此标记的抗原 - 抗体复合物。