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    Method of evaluating a testing element for antigens or antibodies
    1.
    发明授权
    Method of evaluating a testing element for antigens or antibodies 失效
    评估抗原或抗体检测元件的方法

    公开(公告)号：US6040196A

    公开(公告)日：2000-03-21

    申请号：US754647

    申请日：1996-11-21

    申请人： Ayumi Mitoh ,  Tsuneo Hiraide

    发明人： Ayumi Mitoh ,  Tsuneo Hiraide

    IPC分类号： G01N33/545 ,  G01N33/543 ,  G01N33/551 ,  G01N21/00 ,  G01N33/53 ,  A61L5/103

    CPC分类号： G01N33/54386 ,  G01N33/551 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/81

    摘要： An evaluating method of a testing element having an immobilized antigen or antibody on an immobilizing carrier thereof, which immobilized antigen or antibody has yet to react with another antigen or antibody, which involves contacting the testing element with a solution containing an antibody or antigen reactive with the immobilized antigen or antibody, specifically binding a labelling compound to the reactive antibody or antigen to thereby cause a color-developing reaction of the labelling compound, and determining an amount of the antigen or antibody immobilized on the testing element as a function of a level of produced color. Using this evaluation method, a quantitative determination of the immobilized antigen or antibody can be carried out, and thus the performance of the testing element for antigens or antibodies can be evaluated.

    摘要翻译： 固定化抗原或抗体与其他抗原或抗体反应的固定化抗原或抗体的固定化抗原或抗体的检测元件的评价方法，其包括使检测元件与含有与 固定化的抗原或抗体，特异性地将标记化合物结合到反应性抗体或抗原上，从而引起标记化合物的显色反应，并测定固定在测试元件上的抗原或抗体的量作为水平的函数 的颜色。 使用该评价方法，可以进行固定化的抗原或抗体的定量测定，因此可以评价抗原或抗体的检测元件的性能。

    Granular polymer composite and production process thereof as well as diagnostic agent
    2.
    发明授权
    Granular polymer composite and production process thereof as well as diagnostic agent 失效
    颗粒聚合物复合材料及其生产工艺以及诊断剂

    公开(公告)号：US5897953A

    公开(公告)日：1999-04-27

    申请号：US621251

    申请日：1996-03-25

    申请人： Tetsuro Ogawa ,  Tsuneo Hiraide

    发明人： Tetsuro Ogawa ,  Tsuneo Hiraide

    IPC分类号： A61K49/00 ,  C08J3/20 ,  C08K3/32 ,  B32B5/18 ,  B32B5/30 ,  G01N33/545

    CPC分类号： C08K3/32 ,  A61K49/0002 ,  C08J3/203 ,  Y10T428/2991 ,  Y10T428/2998

    摘要： A granular polymer composite comprising polymeric granules having coated on a surface thereof a calcium phosphate compound, at least a part of the particles of the calcium phosphate compound penetrates into the polymeric granules. The composite has a high bonding strength between the polymeric granules as a matrix and a coating of the calcium phosphate compound and also can fully exhibit the functions of a calcium phosphate compound. Using the granular polymer composite, a diagnostic agent which comprises of an antigen or antibody is adsorbed and immobilized on the composite and is therefore useful in diagnostic tests utilizing an antigen-antibody reaction for a number of infectious diseases.

    摘要翻译： 一种颗粒状聚合物复合材料，其包含在其表面上涂覆有磷酸钙化合物的聚合物颗粒，至少一部分磷酸钙化合物的颗粒渗入聚合物颗粒中。 复合材料在作为基质的聚合物颗粒和磷酸钙化合物的涂层之间具有高的结合强度，并且还可以充分发挥磷酸钙化合物的功能。 使用粒状聚合物复合物，将包含抗原或抗体的诊断剂吸附并固定在复合物上，因此可用于利用许多感染性疾病的抗原 - 抗体反应的诊断试验。

    Calcium phosphate-synthetic resin composite body containing calcium phosphate block and method for production thereof
    3.
    发明授权
    Calcium phosphate-synthetic resin composite body containing calcium phosphate block and method for production thereof 失效
    含磷酸钙块的磷酸钙合成树脂复合体及其制造方法

    公开(公告)号：US07056968B2

    公开(公告)日：2006-06-06

    申请号：US10615013

    申请日：2003-07-09

    申请人： Tsuneo Hiraide ,  Yukio Kubota

    发明人： Tsuneo Hiraide ,  Yukio Kubota

    IPC分类号： C08K3/32

    CPC分类号： A61K6/033 ,  A61K6/0008 ,  A61K6/0044 ,  A61K6/0643 ,  C04B14/366 ,  C04B26/04 ,  C04B35/447 ,  C04B2111/00612 ,  C04B2235/3212 ,  C04B2235/5436 ,  C04B2235/77 ,  Y10T428/249956 ,  Y10T428/254 ,  C04B16/04 ,  C04B38/0038 ,  C04B40/0071 ,  C04B41/4582 ,  C04B41/5092 ,  C04B20/002 ,  A61K6/083 ,  C08L33/08 ,  C08L25/06 ,  C08L33/12

    摘要： A calcium phosphate-synthetic resin composite body produced by pressing a calcium phosphate block (or a calcium phosphate block and calcium phosphate particles), and synthetic resin particles I, which are at least partially cross-linked in advance, and uncross-linked, synthetic resin particles II while heating, the calcium phosphate block being exposed on at least part of the surface of the composite body. The above composite body is produced by a method comprising the steps of (a) introducing the calcium phosphate block (or a calcium phosphate block and calcium phosphate particles), the synthetic resin particles I and II into a cavity of a forming die such that the calcium phosphate block is present on at least part of the surface of the composite body, and that the synthetic resin particles surround the calcium phosphate particles, if any; and (b) pressing them in the cavity of the forming die while heating, so that the synthetic resin particles are bonded to each other.

    摘要翻译： 通过将磷酸钙嵌段（或磷酸钙嵌段和磷酸钙颗粒）压制而成的磷酸钙合成树脂复合体和预先至少部分交联的合成树脂颗粒I和未交联的合成树脂 树脂颗粒II在加热时，磷酸钙块在复合体的至少部分表面上露出。 上述复合体通过以下步骤制造的方法：（a）将磷酸钙嵌段（或磷酸钙嵌段和磷酸钙颗粒），合成树脂颗粒I和II引入成形模的空腔，使得 磷酸钙嵌段存在于复合体的至少部分表面上，合成树脂颗粒包围磷酸钙颗粒（如果有的话）; 和（b）在加热的同时将它们压在成型模具的空腔中，使得合成树脂颗粒彼此粘合。

    Test plates for agglutination test and production process thereof
    4.
    发明授权
    Test plates for agglutination test and production process thereof 失效
    凝集试验用试验板及其制造方法

    公开(公告)号：US5736099A

    公开(公告)日：1998-04-07

    申请号：US579584

    申请日：1995-12-28

    申请人： Tsuneo Hiraide ,  Tetsuro Ogawa ,  Ayumi Mitoh ,  Tadahiko Kitano ,  Mikio Nakayama

    发明人： Tsuneo Hiraide ,  Tetsuro Ogawa ,  Ayumi Mitoh ,  Tadahiko Kitano ,  Mikio Nakayama

    IPC分类号： A61B5/00 ,  A61B5/15 ,  G01N33/543 ,  G01N33/53

    CPC分类号： G01N33/54366

    摘要： A test plate for an agglutination test which comprises a plate with a plurality of wells formed thereon, each of the wells having adhered to a surface thereof a protein A and/or a protein G. The agglutination test plate, according to the present invention, when used in an agglutination test, can ensure a clear judgment concerning the formation of an agglutinative image or a non-agglutinative image, along with a good determination sensitivity. A process for the production of such an agglutination test plate is also provided.

    摘要翻译： 一种用于凝集试验的试验板，其包括在其上形成有多个孔的板，每个孔的表面粘附有蛋白A和/或蛋白G.根据本发明的凝集试验板， 当用于凝集试验时，可以确保对凝集图像或非凝集图像的形成的清晰判断以及良好的测定灵敏度。 还提供了生产这种凝集试验板的方法。

    Separating agent, separator and method of separating cell or virus
    6.
    发明授权
    Separating agent, separator and method of separating cell or virus 失效
    分离剂，分离器和分离细胞或病毒的方法

    公开(公告)号：US5085781A

    公开(公告)日：1992-02-04

    申请号：US486220

    申请日：1990-02-28

    申请人： Sumiaki Tsuru ,  Akihiko Yokoo ,  Takeshi Ichitsuka ,  Tsuneo Hiraide

    发明人： Sumiaki Tsuru ,  Akihiko Yokoo ,  Takeshi Ichitsuka ,  Tsuneo Hiraide

    IPC分类号： C12N1/02 ,  C12N7/02

    CPC分类号： C12N7/00 ,  C12N1/02 ,  C12N2710/00051 ,  Y10T436/25375

    摘要： A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 nm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods. The separating agents, separator, and separating methods can be advantageously used to isolate a target cell or virus from a biological fluid in the fields of medical science and biochemistry. The distribution of target cell or virus subsets is not altered by the separation.

    摘要翻译： 一种分离剂，其包含具有开孔形式的平均孔径为约10至约1000微米的聚乙烯醇缩醛树脂; 和具有开孔结构的多孔磷酸钙颗粒，并且还具有两个孔径分布，其中一个分布的平均孔径为约20至约500nm的微孔，另一分布具有约1至约50的小孔 微米的平均孔径。 或者，分离剂包括具有开孔结构并具有作为第一元素的约10至约1000微米的平均孔径的聚乙烯醇缩醛树脂和平均颗粒尺寸为约10的多孔磷酸钙颗粒层 至约2000微米，作为施加到第一元件上的第二元件。 分离剂可以用于分离器中，并且可以用于分离方法中。 分离剂，分离器和分离方法可以有利地用于在医学和生物化学领域从生物流体中分离靶细胞或病毒。 目标细胞或病毒子集的分布不会因分离而改变。

    Sheets, kits and methods for detecting antigens or antibodies
    9.
    发明授权
    Sheets, kits and methods for detecting antigens or antibodies 失效
    用于检测抗原或抗体的片剂，试剂盒和方法

    公开(公告)号：US5827669A

    公开(公告)日：1998-10-27

    申请号：US746485

    申请日：1996-11-12

    申请人： Mikio Nakayama ,  Tadahiko Kitano ,  Ayumi Mitoh ,  Tetsuro Ogawa ,  Tsuneo Hiraide

    发明人： Mikio Nakayama ,  Tadahiko Kitano ,  Ayumi Mitoh ,  Tetsuro Ogawa ,  Tsuneo Hiraide

    IPC分类号： G01N33/53 ,  G01N33/543 ,  G01N33/547 ,  G01N33/551

    CPC分类号： G01N33/54306 ,  G01N33/54313 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/808

    摘要： A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the detection sheet. The detection sheet comprises (a) a fibrous aggregate with carried particles of a calcium phosphate compound having an average particle diameter of about 0.01 to 200 microns and a Ca/P ratio of about 1.0 to 2.0, and (b) an avidin, streptavidin or avidin derivative from which carbohydrates have been extracted immobilized on said calcium phosphate compound. After a biotinylated antigen or antibody is bonded to the immobilized avidin, streptavidin, or avidin derivative of the detection sheet, the detection sheet is contacted with a test solution to thereby bond an antigen or antibody of the test solution to the detection sheet. The detection sheet is then contacted with a solution of labeling compound capable of being specifically bonded to the antigen or antibody of said test solution to detect the thus labeled antigen-antibody complex.

    摘要翻译： 能够在简单的操作中能够以高灵敏度检测生物流体中的抗原或抗体的检测片以及使用检测片的检测试剂盒和检测方法。 检测片包括（a）具有平均粒径为约0.01至200微米并且Ca / P比为约1.0至2.0的带有磷酸钙化合物的载体的纤维聚集体，和（b）抗生物素蛋白，链霉抗生物素蛋白或 提取固定在所述磷酸钙化合物上的碳水化合物的抗生物素蛋白衍生物。 将生物素化的抗原或抗体与检测片的固定化抗生物素蛋白，链亲和素或抗生物蛋白衍生物结合后，使检测片与测试溶液接触，从而将检测溶液的抗原或抗体与检测片结合。 然后将检测片与能够与所述测试溶液的抗原或抗体特异性结合的标记化合物溶液接触，以检测如此标记的抗原 - 抗体复合物。

    Separating agent, separator and method of separating cell or virus
    10.
    再颁专利
    Separating agent, separator and method of separating cell or virus 失效
    分离剂，分离器和分离细胞或病毒的方法

    公开(公告)号：USRE35267E

    公开(公告)日：1996-06-11

    申请号：US193760

    申请日：1994-02-03

    申请人： Sumiaki Tsuru ,  Takeshi Ichitsuka ,  Akihiko Yokoo ,  Tsuneo Hiraide

    发明人： Sumiaki Tsuru ,  Takeshi Ichitsuka ,  Akihiko Yokoo ,  Tsuneo Hiraide

    IPC分类号： C12N1/02 ,  C12N7/02 ,  B01D15/00 ,  B01D39/02 ,  B01D39/14

    CPC分类号： C12N7/00 ,  C12N1/02 ,  C12N2710/00051 ,  Y10T436/25375

    摘要： A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 mm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods. The separating agents, separator, and separating methods can be advantageously used to isolate a target cell or virus from a biological fluid in the fields of medical science and biochemistry. The distribution of target cell or virus subsets is not altered by the separation.

    摘要翻译： 一种分离剂，其包含具有开孔形式的平均孔径为约10至约1000微米的聚乙烯醇缩醛树脂; 和具有开孔结构的多孔磷酸钙颗粒，并且还具有两个孔径分布，其中一个分布的平均孔径为约20至约500mm的微孔，另一分布具有约1至约50的小孔 微米的平均孔径。 或者，分离剂包括具有开孔结构并具有作为第一元素的约10至约1000微米的平均孔径的聚乙烯醇缩醛树脂和平均颗粒尺寸为约10的多孔磷酸钙颗粒层 至约2000微米，作为施加到第一元件上的第二元件。 分离剂可以用于分离器中，并且可以用于分离方法中。 分离剂，分离器和分离方法可以有利地用于在医学和生物化学领域从生物流体中分离靶细胞或病毒。 目标细胞或病毒子集的分布不会因分离而改变。