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1.发明授权公开(公告)号：US12061160B2
公开(公告)日：2024-08-13
申请号：US18170114
申请日：2023-02-16
发明人： Yihua (Bruce) Yu , Marc Taraban , Christopher Fox
CPC分类号： G01N24/082 , G01N33/15
摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess if an alum-containing product, such as a vaccine, has been acceptably resuspended for use following transport and/or storage. This technique allows for the manufacturer and/or distributor and/or end user to monitor for unexpected stressors associated with transport and/or storage including, but not limited to, temperature fluctuations, pH changes, vigorous shaking during transportation, exposure to sunlight, and freezing.
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公开(公告)号：US11585770B2
公开(公告)日：2023-02-21
申请号：US16593145
申请日：2019-10-04
发明人： Yihua (Bruce) Yu , Marc Taraban , Christopher Fox
摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.
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公开(公告)号：US11510875B2
公开(公告)日：2022-11-29
申请号：US14377488
申请日：2013-02-07
发明人： Christopher Fox , Steven G. Reed , Susan Baldwin , Thomas Vedvick
IPC分类号： A61K9/113 , A61K39/39 , A61K39/015 , A61K39/12 , A61K9/107 , A61K47/06 , A61K39/00 , A61K47/24 , A61K47/26
摘要： Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emulsion is greater than about 9.
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