公开(公告)号：US11732011B2

公开(公告)日：2023-08-22

申请号：US17523174

申请日：2021-11-10

申请人： UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

发明人： Neil P. King ,  David Baker ,  Brooke Fiala ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC分类号： C12N7/00 ,  C12N1/15 ,  C12N15/45 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61P31/14 ,  B82Y5/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00 ,  A61K2039/575 ,  C07K2319/735 ,  C12N2760/18022 ,  C12N2760/18322 ,  C12N2760/18522

摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US11192926B2

公开(公告)日：2021-12-07

申请号：US16500331

申请日：2018-04-03

申请人： UNIVERSITY OF WASHINGTON ,  INSTITUTE FOR RESEARCH IN BIOMEDICINE

发明人： Neil P. King ,  David Baker ,  Brooke Nickerson ,  Lance Joseph Stewart ,  Laurent Perez ,  Antonio Lanzavecchia ,  Jessica Marcandalli

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K39/385 ,  A61P31/14 ,  B82Y5/00 ,  C12N7/00

摘要： Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.

公开(公告)号：US20170119874A1

公开(公告)日：2017-05-04

申请号：US15305494

申请日：2015-04-23

申请人： INSTITUTE FOR RESEARCH IN BIOMEDICINE ,  FONDAZIONE CARIPLO

发明人： Antonio Lanzavecchia ,  Laurent Perez

IPC分类号： A61K39/245 ,  C07K14/005

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/57 ,  A61K2039/645 ,  C07K14/005 ,  C07K2319/50 ,  C12N2710/16122 ,  C12N2710/16134 ,  C12N2710/16151 ,  C12N2710/16171 ,  C12N2800/107 ,  C12N2830/20

摘要： The present invention provides for a vector and a gene expression system for producing a soluble pentameric protein complex comprising the HCMV glycoproteins UL128, UL130, UL131, gH and gL or sequence variants thereof, as well as vaccine compositions comprising the same. The present invention further provides for a vaccine composition for use in prophylactically or therapeutically vaccinating against HCMV infections. Also disclosed are methods of producing the inventive vaccine. Furthermore, the present invention pertains to methods of vaccination of humans with the inventive vaccine composition.