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    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of Alzheimer's disease (AD)
    1.
    发明授权
    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of Alzheimer's disease (AD) 失效
    用于还原淀粉状蛋白β肽42（abeta42）产生和用于治疗阿尔茨海默病（AD）的烟酸组合物

    公开(公告)号：US08541435B2

    公开(公告)日：2013-09-24

    申请号：US12737323

    申请日：2009-07-09

    申请人： Uday Saxena ,  Venkateswarulu Akella

    发明人： Uday Saxena ,  Venkateswarulu Akella

    IPC分类号： A61K31/435 ,  C07D213/79

    CPC分类号： A61K31/455 ,  A61K31/05 ,  A61K31/12 ,  A61K31/192 ,  A61K31/196 ,  A61K2300/00

    摘要： The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

    摘要翻译： 本发明公开了（1）烟酸与α-甲氧基对羟基苯基化合物如丁子香酚，香草醛，阿朴替林，阿魏酸，异钌酸和丁子香酚环氧化物的酚酯混合物和（2）上述杂合体的共晶体，特别是共晶体 烟酸 - 丁子香酚与共晶体如丁子香酚和草酸的混合物（3）包含烟酸和一种或多种小分子/增效剂如丁子香酚，姜黄素，肉桂酸，甲氯芬那酸的组合的新型药物组合物及其在治疗 由淀粉样β肽-42（Abeta42）的过剩产生引起的疾病或疾病，其沉积，积累和斑块形成，包括阿尔茨海默病，痴呆和轻度认知障碍以及其他神经变性疾病如帕金森病和缺血性中风。

    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad)
    2.
    发明申请
    Niacin compositions for reduction of amyloid beta peptide 42 (abeta 42) production and for treatment of alzheimer's disease (ad) 失效
    用于还原淀粉状蛋白β肽42（abeta 42）生产和用于治疗阿尔茨海默氏病（ad）的烟酸组合物

    公开(公告)号：US20110097347A1

    公开(公告)日：2011-04-28

    申请号：US12737323

    申请日：2009-07-09

    申请人： Uday Saxena ,  Venkateswarulu Akella

    发明人： Uday Saxena ,  Venkateswarulu Akella

    IPC分类号： A61K31/4406 ,  C07D213/80 ,  C07D405/12 ,  A61K31/4427 ,  A61K31/7088 ,  A61K38/02 ,  A61K39/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/00

    CPC分类号： A61K31/455 ,  A61K31/05 ,  A61K31/12 ,  A61K31/192 ,  A61K31/196 ,  A61K2300/00

    摘要： The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease and ischemic stroke.

    摘要翻译： 本发明公开了（1）烟酸与α-甲氧基对羟基苯基化合物如丁子香酚，香草醛，阿朴替林，阿魏酸，异钌酸和丁子香酚环氧化物的酚酯混合物和（2）上述杂合体的共晶体，特别是共晶体 烟酸 - 丁子香酚与共晶体如丁子香酚和草酸的混合物（3）包含烟酸和一种或多种小分子/增效剂如丁子香酚，姜黄素，肉桂酸，甲氯芬那酸的组合的新型药物组合物及其在治疗 由淀粉样蛋白β肽42（A＆bgr; 42）的过量产生引起的疾病或疾病，其沉积，积累和斑块形成，包括阿尔茨海默病，痴呆和轻度认知障碍以及其他神经变性疾病如帕金森病和缺血性 行程。

    Novel Niacin Compositions for Reduction of Amyloid Beta Peptide 42 (AB42) Production and for Treatment of Alzheimer's Disease
    3.
    发明申请
    Novel Niacin Compositions for Reduction of Amyloid Beta Peptide 42 (AB42) Production and for Treatment of Alzheimer's Disease 审中-公开
    用于还原淀粉样β肽42（AB42）的新型烟酸组合物生产和治疗阿尔茨海默病

    公开(公告)号：US20130338199A1

    公开(公告)日：2013-12-19

    申请号：US13971151

    申请日：2013-08-20

    申请人： Uday Saxena ,  Venkateswarlu Akella

    发明人： Uday Saxena ,  Venkateswarlu Akella

    IPC分类号： C07D213/80

    CPC分类号： C07D213/80 ,  A61K31/085 ,  A61K31/12 ,  A61K31/192 ,  A61K31/196 ,  A61K31/455 ,  A61K2300/00

    摘要： The present invention discloses (1) phenolic ester hybrids of niacin with m-methoxy-p-hydroxy phenyl compounds like eugenol, vanillin, apocynin, ferulic acid, isoferulic acid and eugenol epoxide and (2) cocrystals of hybrids as above, particularly cocrystal of niacin-eugenol hybrid with cocrystal former like eugenol and oxalic acid (3) novel pharmaceutical compositions comprising a combination of niacin and one or more small molecule/potentiating agent like eugenol, curcumin, cinnamic acid, meclofenamic acid, and their use in the treatment of a disorder or a disease caused by excess production of amyloid beta peptide-42 (Aβ42), its deposition, accumulation, and plaque formation including Alzheimer's Disease, dementia and mild cognitive impairment as well as other neurodegenerative diseases such as Parkinson's Disease, Huntington's disease, multiple sclerosis, amytrophic lateral sclerosis and ischemic stroke.

    摘要翻译： 本发明公开了（1）烟酸与α-甲氧基对羟基苯基化合物如丁子香酚，香草醛，阿朴替林，阿魏酸，异钌酸和丁子香酚环氧化物的酚酯混合物和（2）上述杂合体的共晶体，特别是共晶体 烟酸 - 丁子香酚与共晶体如丁子香酚和草酸的混合物（3）包含烟酸和一种或多种小分子/增效剂如丁子香酚，姜黄素，肉桂酸，甲氯芬那酸的组合的新型药物组合物及其在治疗 由淀粉样β肽-42（Abeta42）的过量产生引起的疾病或疾病，其沉积，积累和斑块形成，包括阿尔茨海默氏病，痴呆和轻度认知障碍以及其他神经变性疾病如帕金森病，亨廷顿舞蹈病， 多发性硬化，肌萎缩性侧索硬化和缺血性卒中。