公开(公告)号：US20160090366A1

公开(公告)日：2016-03-31

申请号：US14890147

申请日：2014-05-09

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Raju Reddy

IPC分类号： C07D241/20 ,  C07D241/18 ,  C07D241/16 ,  C07D239/47 ,  C07D239/30 ,  C07D239/34 ,  C07D239/42 ,  C07D239/38 ,  C07D241/12 ,  C07D239/26

CPC分类号： C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.

摘要翻译： 公开了具有以下结构的化合物或其药学上可接受的盐或酯：X1-L-X2其中L是包含烯酮的连接部分; 并且X 1和X 2各自独立地为任选取代的N-杂环。 还公开了用化合物治疗肺部病症和其他器官或系统状况的方法。

公开(公告)号：US20180086723A1

公开(公告)日：2018-03-29

申请号：US15828163

申请日：2017-11-30

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Raju Reddy

IPC分类号： C07D241/20 ,  C07D241/18 ,  C07D241/16 ,  C07D241/12 ,  C07D239/52 ,  C07D239/26 ,  C07D239/42 ,  C07D239/38 ,  C07D239/34 ,  C07D239/30 ,  C07D239/47

CPC分类号： C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.

公开(公告)号：US10167265B2

公开(公告)日：2019-01-01

申请号：US15828163

申请日：2017-11-30

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  The United States of America as Represented by the Department of Veterans Affairs

发明人： Raju Reddy

IPC分类号： C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.

公开(公告)号：US09862690B2

公开(公告)日：2018-01-09

申请号：US14890147

申请日：2014-05-09

申请人： University of Pittsburgh—of the Commonwealth System of Higher Education ,  The United States of America as Represented by the Department of Veterans Affairs

发明人： Raju Reddy

IPC分类号： A61K31/497 ,  C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

CPC分类号： C07D241/20 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D241/12 ,  C07D241/16 ,  C07D241/18

摘要： Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X1-L-X2 wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently an optionally-substituted N-heterocycle. Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.