Abstract:
The daily pill dispensing apparatus has a front section connected to a back section, a top hinge disposed on the top between the front section and the back section, a dispenser lid connected to the top hinge and pivotally covering the front section, a septet of top doors disposed atop the back section, each top door pivotally covering a separate compartment of the back section via the top hinge, a day indicia disposed atop each top door, a dispensing door hingedly separating each compartment from the front section, each dispensing door opening into the front section, a display disposed atop the dispenser lid, a controls disposed in the front section bottom, the controls in communication with the display and with each dispensing door, whereby each dispensing door sequentially opens, each dispensing door opening only one day per week, and battery power.
Abstract:
The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.
Abstract:
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or more non-endogenous glycosylation sites.
Abstract:
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
Abstract:
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
Abstract:
Method and system for incremental backup of data containers with fixed length records is provided. Initially, a backup application copies all stored data containers to create an initial backup container. A data structure corresponding to the first backup operation is also created. The data structure maintains unique file identifiers for each data container and information regarding when a record was added. The data structure is created and maintained by an application that also creates, updates, and modifies the fixed length records. The application updates the base data structure when records are added to a data container, after the initial backup. For a next backup operation, the initial data structure is compared to an updated data structure that is current at the next backup time. The comparison identifies the new records that were added (or updated) since the initial backup operation. The backup application then incrementally copies the new records.
Abstract:
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Abstract:
The disclosure relates to Cerberus/Coco polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11.