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    FLOWABLE COMPOSITION THAT HARDENS ON DELIVERY TO A TARGET TISSUE SITE BENEATH THE SKIN
    1.
    发明申请
    FLOWABLE COMPOSITION THAT HARDENS ON DELIVERY TO A TARGET TISSUE SITE BENEATH THE SKIN 审中-公开
    流向组合物，将成分递送至目标组织网站BENEATH THE SKIN

    公开(公告)号：US20160038407A1

    公开(公告)日：2016-02-11

    申请号：US14886760

    申请日：2015-10-19

    申请人： Warsaw Orthopedic, Inc.

    发明人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    IPC分类号： A61K9/00 ,  A61K47/34 ,  A61K51/12 ,  A61K31/573 ,  A61K9/16 ,  A61K47/10

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/16 ,  A61K31/573 ,  A61K47/10 ,  A61K47/34 ,  A61K51/1213

    摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.

    摘要翻译： 提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为 能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位 包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。 在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。

    Compositions for treating bone defects
    4.
    发明授权
    Compositions for treating bone defects 有权

    公开(公告)号：US10441679B2

    公开(公告)日：2019-10-15

    申请号：US16128784

    申请日：2018-09-12

    申请人： WARSAW ORTHOPEDIC INC.

    发明人： Jeffrey M. Gross ,  Steve Peckham ,  Jeffrey L. Scifert ,  Jeffrey Badura ,  Nelson Scarborough ,  Scott Vickers

    IPC分类号： A61L27/22 ,  A61L27/46 ,  A61L27/48 ,  A61L27/54 ,  A61K38/00

    摘要： In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.

    Flowable composition that hardens on delivery to a target tissue site beneath the skin
    6.
    发明授权
    Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权

    公开(公告)号：US09744124B2

    公开(公告)日：2017-08-29

    申请号：US14886760

    申请日：2015-10-19

    申请人： Warsaw Orthopedic, Inc.

    发明人： Susan J. Drapeau ,  William F. McKay ,  Nelson Scarborough

    IPC分类号： A61K9/00 ,  A61K31/573 ,  A61K47/10 ,  A61K47/34 ,  A61K51/12 ,  A61K9/16

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/16 ,  A61K31/573 ,  A61K47/10 ,  A61K47/34 ,  A61K51/1213

    摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.