公开(公告)号：US20190231931A1

公开(公告)日：2019-08-01

申请号：US16379276

申请日：2019-04-09

申请人： LifeCell Corporation

发明人： Hui Xu ,  Li Ting Huang ,  Hua Wan ,  Rick T. Owens ,  Nathaniel Bachrach

IPC分类号： A61L27/36 ,  G01N33/573 ,  A61L27/54 ,  A61L27/24 ,  A61L27/58

CPC分类号： A61L27/3687 ,  A61L27/24 ,  A61L27/3695 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/412 ,  A61L2430/34 ,  A61L2430/40 ,  G01N33/573

摘要： Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.

公开(公告)号：US20190201580A1

公开(公告)日：2019-07-04

申请号：US16329010

申请日：2017-08-31

申请人： LifeCell Corporation

发明人： Aaron Barere ,  Sangwook Park ,  Kai-Roy Wang

IPC分类号： A61L27/36 ,  A61F2/12 ,  A61L27/56

CPC分类号： A61L27/362 ,  A61F2/0063 ,  A61F2/12 ,  A61F2210/0057 ,  A61F2220/0008 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61L27/3641 ,  A61L27/3666 ,  A61L27/3695 ,  A61L27/56 ,  A61L2430/04

摘要： The present disclosure provides devices for treating breasts. The devices (100) include a sheet of acellular tissue matrix having a predefined shape that allows for complete or enhanced coverage of an anterior portion of a breast implant or tissue expander or to support an implant and/or surrounding tissues. The sheet includes curved upper and lower borders or edges.

公开(公告)号：US20180282699A1

公开(公告)日：2018-10-04

申请号：US15841004

申请日：2017-12-13

申请人： The Research Foundation for The State University of New York

发明人： Sha Jin ,  Kaiming Ye ,  Huanjing Bi

IPC分类号： C12N5/071 ,  C12N5/074 ,  C12N5/0789 ,  A61L27/14 ,  A61L27/36

CPC分类号： C12N5/0677 ,  A61L27/14 ,  A61L27/3633 ,  A61L27/3695 ,  A61L2430/34 ,  C12N5/0647 ,  C12N5/0696 ,  C12N2501/117 ,  C12N2501/16 ,  C12N2501/599 ,  C12N2533/54 ,  C12N2533/90

摘要： Human pluripotent stem cells (hPSCs) are promising cell source to produce therapeutic endocrine cells for diabetes treatment. A gel solution made by decellularized tissue-specific extracellular matrix (dpECM) significantly promotes three-dimensional (3D) islet-like organogenesis during induced hPSC differentiation into endocrine lineages. Islet organoids are self-organized even in a two-dimensional (2D) culture mode. Cells derived from hPSCs differentiated on such ECM coated substrates exhibit similar cellular composition to native pancreatic islets. These cells express islet signature markers insulin, PDX-1, C-peptide, MafA, glucagon, somatostatin, and pancreatic polypeptide, and secrete more insulin in response to glucose level compared to a traditional matrix substrate (Matrigel). The dpECM facilitates generating more C-peptide+/glucagon− cells rather than C-peptide+/glucagon+ cells. Remarkably, dpECM also facilitated intra-organoid vascularity by generating endothelial cells and pericytes. Furthermore, dpECM niches also induced intra-organoid microvascularization during pancreatic differentiation.

公开(公告)号：US20180177919A1

公开(公告)日：2018-06-28

申请号：US15847158

申请日：2017-12-19

申请人： LifeCell Corporation

发明人： Israel James Jessop

IPC分类号： A61L27/36 ,  A61L27/50 ,  B26D3/24 ,  F25D31/00

CPC分类号： A61L27/3691 ,  A61B17/322 ,  A61B2017/3225 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/50 ,  A61L2400/08 ,  A61L2400/18 ,  A61L2430/34 ,  B26D3/24 ,  B26D7/018 ,  B26D7/10 ,  F25D31/00

摘要： The present application relates to a method and device for processing tissue. The method and device allow for machining of soft tissue samples to produce uniform shapes (e.g., uniform thicknesses) or reliably produce alterations such as openings or holes in soft tissue products. The method and device can alternatively or additionally be used to process tissue to produce particulates with desired properties.

公开(公告)号：US20180055624A1

公开(公告)日：2018-03-01

申请号：US15691865

申请日：2017-08-31

申请人： LifeCell Corporation

发明人： Aaron Barere ,  Sangwook Park ,  Kai-Roy Wang

IPC分类号： A61F2/12 ,  A61L27/36 ,  A61L27/56

CPC分类号： A61L27/362 ,  A61F2/0063 ,  A61F2/12 ,  A61F2210/0057 ,  A61F2220/0008 ,  A61F2230/0008 ,  A61F2230/0013 ,  A61L27/3641 ,  A61L27/3666 ,  A61L27/3695 ,  A61L27/56 ,  A61L2430/04

摘要： The present disclosure provides devices and methods for treating breasts. The devices can include an acellular tissue matrix having a predefined shape that allows for complete or enhanced coverage of an anterior portion of a breast implant or tissue expander or to support an implant and/or surrounding tissues.

公开(公告)号：US20170296581A1

公开(公告)日：2017-10-19

申请号：US15639692

申请日：2017-06-30

申请人： Warsaw Orthopedic, Inc.

发明人： Keyvan Behnam ,  Guobao Wei ,  Nanette Forsyth

IPC分类号： A61K35/00 ,  A61K35/32 ,  A61L27/36 ,  A61L27/54 ,  A61L27/38 ,  A61F2/28 ,  A61F2/30

CPC分类号： A61K35/12 ,  A61F2/28 ,  A61F2002/30059 ,  A61F2310/00359 ,  A61K35/00 ,  A61K35/32 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/3834 ,  A61L27/54 ,  A61L2430/02 ,  A61L2430/40

摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.

公开(公告)号：US09782516B2

公开(公告)日：2017-10-10

申请号：US13842445

申请日：2013-03-15

申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.

发明人： Stephen D. Pacetti ,  John Stankus

IPC分类号： A61F2/00 ,  A61L27/36 ,  A61L31/16

CPC分类号： A61L27/3695 ,  A61L27/3604 ,  A61L31/16 ,  A61L2400/06 ,  A61L2430/34

摘要： A therapeutic formulation is described for a drug delivery balloon comprising a therapeutic formulation which includes a therapeutic agent and an adhesion additive. The adhesion additive promotes adhesion of the therapeutic formulation a vessel wall of a subject. A system and a method of manufacturing a system including an expandable member having a working length with the therapeutic formulation disposed along at least a portion of the working length is also provided.

公开(公告)号：US20170095456A1

公开(公告)日：2017-04-06

申请号：US15381319

申请日：2016-12-16

申请人： Hans M. Albertsen

发明人： Hans M. Albertsen

IPC分类号： A61K31/436 ,  A61K31/4745 ,  A61K31/519 ,  A61K38/07 ,  A61K31/5377 ,  A61K9/20 ,  A61K31/496

CPC分类号： A61K31/65 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/7015 ,  A61K31/05 ,  A61K31/12 ,  A61K31/122 ,  A61K31/436 ,  A61K31/44 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K38/07 ,  A61L27/34 ,  A61L27/3695

摘要： The present invention is a method of treating ETD and in particular a method of treating endometriosis and adenomyosis by administering a compound comprised of Rapamycin or a similar mTOR inhibitor and a hormonal contraceptive. The compound may be a natural compound or a synthetic compound. The compound may be in pill form, transdermal patch form, or vaginal ring form.

公开(公告)号：US20160270912A1

公开(公告)日：2016-09-22

申请号：US14914109

申请日：2014-08-22

申请人： NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

发明人： Yasuhide NAKAYAMA ,  Tomonori OIE

IPC分类号： A61F2/24 ,  C12N5/077

CPC分类号： A61F2/2415 ,  A61L27/3645 ,  A61L27/3695 ,  A61L2430/20 ,  C12N5/0652 ,  C12N2535/00 ,  C12N2539/00

摘要： The present invention provides a base material for forming a connective tissue structure which can accurately cut the connective tissue structure to a predetermined shape and a method for producing the connective tissue structure. A cutting-line forming groove (28) is formed in a surface of a base material (19). The base material (19) is placed under an environment in which a biological tissue material is present. A membranous connective tissue structure (20) is formed on the surface of the base material (19). At that time, a connective tissue (30) is made to invade into the cutting-line forming groove (28). A cutting line (31) for cutting is formed in the connective tissue structure (20). The connective tissue structure (20) is accurately cut along the cutting line (31) to a predetermined shape.

摘要翻译： 本发明提供一种用于形成可以将结缔组织结构精确地切割成预定形状的结缔组织结构的基材和用于生产结缔组织结构的方法。 在基材（19）的表面形成切割线形成槽（28）。 基材（19）放置在存在生物组织材料的环境下。 在基材（19）的表面上形成膜结缔组织结构（20）。 此时，结缔组织（30）被侵入到切割线形成槽（28）中。 在结缔组织结构（20）中形成用于切割的切割线（31）。 结缔组织结构（20）沿着切割线（31）精确地切割成预定的形状。

公开(公告)号：US09433702B2

公开(公告)日：2016-09-06

申请号：US13006949

申请日：2011-01-14

申请人： Theodore I. Malinin

发明人： Theodore I. Malinin

IPC分类号： A61L27/36 ,  A61F2/30 ,  A61K35/32 ,  A61L27/56 ,  A61F2/44

CPC分类号： A61L27/3695 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2002/30764 ,  A61F2002/4495 ,  A61F2310/00365 ,  A61K35/32 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3683 ,  A61L27/56 ,  A61L2430/06 ,  A61L2430/40

摘要： Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.