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公开(公告)号：US20110091992A1
公开(公告)日：2011-04-21
申请号：US12666345
申请日：2008-07-10
IPC分类号： C07K16/28 , G01N33/566 , G06G7/60
CPC分类号： C07K16/2866 , C07K16/00 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/72 , C07K2317/92
摘要： The present invention provides crystalline forms of a human IgG Fc variant comprising one or more amino acid residues that provides for enhanced effector function, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. The present invention also provides machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them. The present invention also provides human IgG Gc variants with reduced binding to at least one FcγR.
摘要翻译： 本发明提供了包含提供增强的效应子功能的一个或多个氨基酸残基，获得这种晶体的方法和高分辨率X射线衍射结构和原子结构坐标的人IgG Fc变体的结晶形式。 本发明还提供了嵌入人IgG Fc变体的三维原子结构坐标的机器可读介质以及使用它们的方法。 本发明还提供与至少一种FcγR结合降低的人IgG Gc变体。
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2.发明授权Crystals and structure of a human IgG Fc variant with enhanced FcRn binding 有权具有增强的FcRn结合的人IgG Fc变体的晶体和结构公开(公告)号：US08775090B2
公开(公告)日：2014-07-08
申请号：US13133845
申请日：2009-12-10
CPC分类号： C07K16/00 , C07K16/1027 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
摘要翻译： 本文提供包含提供对人新生儿Fc受体的增加的结合亲和力的三突变M252Y / S254T / T256E的人IgG Fc变体的结晶形式，获得这种晶体的方法和高分辨率X射线衍射结构和原子结构坐标 。 还提供了嵌入人IgG Fc变体的三维原子结构坐标的机器可读介质以及使用它们的方法。
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3.发明申请CRYSTALS AND STRUCTURE OF A HUMAN IgG Fc VARIANT WITH ENHANCED FcRn BINDING 有权具有增强FcRn结合的人IgG Fc变体的晶体和结构公开(公告)号：US20110288276A1
公开(公告)日：2011-11-24
申请号：US13133845
申请日：2009-12-10
CPC分类号： C07K16/00 , C07K16/1027 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
摘要翻译： 本文提供包含提供对人新生儿Fc受体的增加的结合亲和力的三突变M252Y / S254T / T256E的人IgG Fc变体的结晶形式，获得这种晶体的方法和高分辨率X射线衍射结构和原子结构坐标 。 还提供了嵌入人IgG Fc变体的三维原子结构坐标的机器可读介质以及使用它们的方法。
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4.发明授权Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use 有权特异性结合金黄色葡萄球菌α毒素的抗体及其使用方法公开(公告)号：US09527905B2
公开(公告)日：2016-12-27
申请号：US13983804
申请日：2012-02-07
申请人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
发明人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
摘要翻译： 本文提供了与抗-α毒素抗体和片段有关的组合物，制备方法和使用方法。
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5.发明申请ANTIBODIES THAT SPECIFICALLY BIND STAPHYLOCOCCUS AUREUS ALPHA TOXIN AND METHODS OF USE 有权特异性印迹黄曲霉毒素的毒物和使用方法公开(公告)号：US20140072577A1
公开(公告)日：2014-03-13
申请号：US13983804
申请日：2012-02-07
申请人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
发明人： Bret Sellman , Christine Tkaczyk , Lei Hua , Partha Chowdhury , Reena Varkey , Melissa Damschroder , Li Peng , Vaheh Oganesyan , Jamese Johnson Hilliard
IPC分类号： C07K16/12
CPC分类号： C07K16/1271 , A61K38/14 , A61K39/40 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/90 , C07K2317/92 , G01N33/56938 , G01N2333/31 , G01N2800/20 , G01N2800/44 , G01N2800/709 , A61K2300/00
摘要： Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
摘要翻译： 本文提供了与抗-α毒素抗体和片段有关的组合物，制备方法和使用方法。
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