公开(公告)号：US10350217B2

公开(公告)日：2019-07-16

申请号：US15481596

申请日：2017-04-07

Applicant: University of Massachusetts ,  Worcester Polytechnic Institute

Inventor： Paul Kaufman ,  Jessica Lopes Da Rosa-Spiegler ,  Reeta Prusty Rao ,  Ahmed Fazly

IPC: A61K31/55 ,  A61K31/496 ,  A61K31/24 ,  A61K31/167 ,  A61K31/402 ,  A61K31/381 ,  A61K31/47 ,  A61K31/44 ,  A61K31/517 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/165 ,  A61K31/519 ,  A61K31/5375 ,  A61K31/495 ,  A01N37/22 ,  A01N43/12 ,  A01N43/36 ,  A01N43/42 ,  A01N43/58 ,  A01N43/60 ,  A01N43/713 ,  A01N43/84 ,  A61K31/166 ,  A61K31/506

Abstract: Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.

公开(公告)号：US20150168403A1

公开(公告)日：2015-06-18

申请号：US14575205

申请日：2014-12-18

Applicant: Worcester Polytechnic Institute

Inventor： Reeta Prusty Rao

IPC: G01N33/569

CPC classification number: G01N33/56961 ,  C12Q1/18 ,  G01N33/6872 ,  G01N2333/37 ,  G01N2500/04 ,  G01N2500/10

Abstract: The present invention relates to methods of screening for antifungal agents by identifying agents that bind to or otherwise inhibit indole-3-acetic acid (IAA) or that bind to or otherwise inhibit the expression or activity of a protein within the Yap family or a gene encoding a protein within the Yap family.

Abstract translation: 本发明涉及通过鉴定结合或以其它方式抑制吲哚-3-乙酸（IAA）或结合或以其它方式抑制Yap家族或基因内的蛋白质的表达或活性的试剂筛选抗真菌剂的方法 编码Yap家族内的蛋白质。

公开(公告)号：US09648880B2

公开(公告)日：2017-05-16

申请号：US14017914

申请日：2013-09-04

Applicant: University of Massachusetts ,  Worcester Polytechnic Institute

Inventor： Paul Kaufman ,  Jessica Lopes Da Rosa-Spiegler ,  Reeta Prusty Rao ,  Ahmed Fazly

IPC: A01N43/84 ,  A61K31/496 ,  A01N37/22 ,  A01N43/12 ,  A01N43/36 ,  A01N43/42 ,  A01N43/58 ,  A01N43/60 ,  A01N43/713 ,  A61K31/166 ,  A61K31/167 ,  A61K31/381 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5375

CPC classification number: A61K31/55 ,  A01N37/22 ,  A01N43/12 ,  A01N43/36 ,  A01N43/42 ,  A01N43/58 ,  A01N43/60 ,  A01N43/713 ,  A01N43/84 ,  A61K31/165 ,  A61K31/166 ,  A61K31/167 ,  A61K31/24 ,  A61K31/381 ,  A61K31/402 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5375

Abstract: Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.