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公开(公告)号：US20080220425A1
公开(公告)日：2008-09-11
申请号：US11926042
申请日：2007-10-28
申请人： WuPo Ma , Jorge Garces , Jeff G. Hall , Andrew A. Lukowiak
发明人： WuPo Ma , Jorge Garces , Jeff G. Hall , Andrew A. Lukowiak
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , A61K38/00 , C07K2319/02 , C12N9/1252 , C12N9/22 , C12N2710/16122 , C12Q1/6865 , C12Q1/6869 , C12Q2525/307 , C12Q2521/301 , C12Q2521/337
摘要： The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for amplifying a synthetic DNA from a target nucleic acid, forming a nucleic acid cleavage structure on the synthetic DNA, and detecting cleavage of the nucleic acid cleavage structure as an indicator of the preset of the target nucleic acid.
摘要翻译： 本发明涉及核酸序列的检测和表征的组合物和方法以及核酸序列的变化。 本发明涉及用于从靶核酸扩增合成DNA的方法，在合成DNA上形成核酸切割结构，并检测核酸切割结构的切割作为靶核酸的预设的指标。
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公开(公告)号：US20080160524A1
公开(公告)日：2008-07-03
申请号：US11837468
申请日：2007-08-10
申请人： WuPo Ma , Jorge Garces , Jeff G. Hall , Andrew A. Lukowiak
发明人： WuPo Ma , Jorge Garces , Jeff G. Hall , Andrew A. Lukowiak
CPC分类号： C12N9/22 , A61K38/00 , C07K2319/02 , C12N9/1252 , C12N2710/16111 , C12N2710/16122 , C12Q1/6844 , C12Q1/6865 , C12Q1/6869 , C12Q2525/307 , C12Q2521/301 , C12Q2521/337
摘要： The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for amplifying a synthetic DNA from a target nucleic acid, forming a nucleic acid cleavage structure on the synthetic DNA, and detecting cleavage of the nucleic acid cleavage structure as an indicator of the preset of the target nucleic acid.
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公开(公告)号：US08063184B2
公开(公告)日：2011-11-22
申请号：US12898490
申请日：2010-10-05
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US07935800B2
公开(公告)日：2011-05-03
申请号：US11642815
申请日：2006-12-19
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20110104682A1
公开(公告)日：2011-05-05
申请号：US12898490
申请日：2010-10-05
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20090142754A1
公开(公告)日：2009-06-04
申请号：US11929404
申请日：2007-10-30
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US07150982B2
公开(公告)日：2006-12-19
申请号：US10084839
申请日：2002-02-26
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
IPC分类号： C12N9/22
CPC分类号： C12N9/1252 , C12N9/22 , C12Q1/6809 , C12Q1/6823 , C12Q1/6827 , H04L29/06 , H04L29/06027 , H04L69/32 , C12Q2561/109 , C12Q2537/162 , C12Q2525/161
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US07807806B2
公开(公告)日：2010-10-05
申请号：US11929404
申请日：2007-10-30
申请人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , Wupo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim T. Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael W. Kaiser , Robert W. Kwiatkowski , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , Wupo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20080293046A1
公开(公告)日：2008-11-27
申请号：US11642815
申请日：2006-12-19
申请人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
发明人： Hatim Allawi , Brad T. Argue , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Lin Ji , Michael Kaiser , Robert W. Kwiatkowski, JR. , Andrew A. Lukowiak , Victor Lyamichev , Natalie E. Lyamicheva , WuPo Ma , Bruce P. Neri , Sarah M. Olson , Marilyn C. Olson-Munoz , James J. Schaefer , Zbigniev Skrzypczynski , Tsetska Y. Takova , Lisa C. Thompson , Kevin L. Vedvik
CPC分类号： C12Q1/6823 , C12N9/1252 , C12N9/22 , C12Q1/683 , Y10T436/143333 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US07045289B2
公开(公告)日：2006-05-16
申请号：US09864636
申请日：2001-05-24
申请人： Hatim Allawi , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , WuPo Ma , Marilyn C. Olson-Munoz , Sarah M. Olson , James J. Schaefer , Zbigniew Skrzypczynski , Tsetska Y. Takova , Kevin L. Vedvik , Natalie Lyamichev , Bruce P. Neri
发明人： Hatim Allawi , Christian Tor Bartholomay , LuAnne Chehak , Michelle L. Curtis , Peggy S. Eis , Jeff G. Hall , Hon S. Ip , Michael Kaiser , Robert W. Kwiatkowski, Jr. , Andrew A. Lukowiak , Victor Lyamichev , WuPo Ma , Marilyn C. Olson-Munoz , Sarah M. Olson , James J. Schaefer , Zbigniew Skrzypczynski , Tsetska Y. Takova , Kevin L. Vedvik , Natalie Lyamichev , Bruce P. Neri
IPC分类号： C12Q1/68
CPC分类号： C12N9/22 , C12N9/1252 , C12Q1/6823 , C12Q1/683 , H04L29/06 , H04L29/06027 , H04L69/32 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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