公开(公告)号：US08901140B2

公开(公告)日：2014-12-02

申请号：US13395892

申请日：2010-08-26

Applicant: Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

Inventor： Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

IPC: C07D401/14 ,  A61K31/4709 ,  C07F9/6512 ,  A61P35/00

CPC classification number: A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07F9/60 ,  C07F9/65128

Abstract: 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Abstract translation: 公开了6-氨基喹唑啉或3-氰基喹啉衍生物，其制备方法和药物用途。 具体地，本公开公开了通式（I）所示的新的6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变异构体，对映异构体，非对映异构体，外消旋体或其药学上可接受的盐或其代谢前体或前药， 用作特别是作为蛋白激酶抑制剂的治疗剂，其中通式（I）的每个取代基如说明书中所定义。

公开(公告)号：US20120165352A1

公开(公告)日：2012-06-28

申请号：US13395892

申请日：2010-08-26

Applicant: Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

Inventor： Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

IPC: A61K31/517 ,  C07D403/12 ,  C07F9/6512 ,  A61P35/00 ,  C12N9/99 ,  C07F9/60 ,  C07D401/14 ,  A61K31/4709

CPC classification number: A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07F9/60 ,  C07F9/65128

Abstract: 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Abstract translation: 公开了6-氨基喹唑啉或3-氰基喹啉衍生物，其制备方法和药物用途。 具体地，本公开公开了通式（I）所示的新的6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变异构体，对映异构体，非对映异构体，外消旋体或其药学上可接受的盐或其代谢前体或前药， 用作特别是作为蛋白激酶抑制剂的治疗剂，其中通式（I）的每个取代基如本说明书中所定义。

公开(公告)号：US20130131068A1

公开(公告)日：2013-05-23

申请号：US13811957

申请日：2011-07-26

Applicant: Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

Inventor： Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

IPC: C07D487/04 ,  A61K45/00 ,  A61K31/502

CPC classification number: A61K31/502 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/5377 ,  A61K45/00 ,  C07D487/04 ,  A61K2300/00

Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

Abstract translation: 描述由式（I）表示的酞嗪酮酮衍生物，其制备方法，含有该衍生物的药物组合物，其作为聚（ADP-核糖）聚合酶（PARP）抑制剂的用途及其癌症治疗方法。

公开(公告)号：US09273052B2

公开(公告)日：2016-03-01

申请号：US13811957

申请日：2011-07-26

Applicant: Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

Inventor： Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

IPC: A61K31/495 ,  C07D487/04 ,  A61K31/502 ,  A61K45/00 ,  A61K31/4188

CPC classification number: A61K31/502 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/5377 ,  A61K45/00 ,  C07D487/04 ,  A61K2300/00

Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

Abstract translation: 描述由式（I）表示的酞嗪酮酮衍生物，其制备方法，含有该衍生物的药物组合物，其作为聚（ADP-核糖）聚合酶（PARP）抑制剂的用途及其癌症治疗方法。

公开(公告)号：US20130338190A1

公开(公告)日：2013-12-19

申请号：US14001778

申请日：2012-02-10

Applicant: Xin Li ,  Bin Wang

Inventor： Xin Li ,  Bin Wang

IPC: C07D401/14 ,  C07C57/13 ,  C07C309/04 ,  C07C57/145 ,  C07C309/30

CPC classification number: C07D401/14 ,  A61K31/4709 ,  C07C57/13 ,  C07C57/145 ,  C07C309/04 ,  C07C309/30

Abstract: Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method thereof, and a use thereof as a therapeutic agent, and especially as a protein kinase inhibitor.

Abstract translation: 由式（I）表示的是（E）-N- [4 - [[3-氯-4-（2-吡啶基甲氧基）苯基]氨基] -3-氰基-7-乙氧基-6 - 喹啉基] -3 - [（2R）-1-甲基吡咯烷-2-基]丙-2-烯酰胺，其制备方法及其作为治疗剂的用途，特别是作为蛋白激酶抑制剂。

公开(公告)号：US20150270751A1

公开(公告)日：2015-09-24

申请号：US14428296

申请日：2012-09-29

Applicant: Pingshan CAO ,  Xin LI ,  Xin LI ,  EMERSON ELECTRIC CO.

Inventor： Pingshan Cao ,  Xin Li ,  Xin Li

IPC: H02K1/27 ,  F04D25/02 ,  F04D25/06 ,  H02K1/02

CPC classification number: H02K1/2773 ,  F04D25/026 ,  F04D25/06 ,  H02K1/02

Abstract: A rotor for a dynamoelectric machine includes a rotor core having an outer periphery and at least a first set of magnets positioned within the outer periphery of the rotor core. The first set of magnets includes at least two block magnets and an arc magnet. The block magnets have a substantially parallel magnetization pattern and the arc magnet has a substantially radial magnetization pattern. The arc magnet has a concave surface facing the outer periphery of the rotor core. The first set of magnets defines a pole of the rotor. Rotors with other magnet configurations, and dynamoelectric machines and compressors incorporating such rotors, are also disclosed.

Abstract translation: 一种用于电动机的转子包括具有外周边的转子芯和至少位于转子芯的外圆周内的第一组磁体。 第一组磁体包括至少两个块磁体和电弧磁体。 块状磁体具有基本平行的磁化模式，并且电弧磁体具有基本上径向的磁化模式。 电弧磁体具有面向转子芯的外周的凹面。 第一组磁体限定了转子的极点。 还公开了具有其它磁体配置的转子，以及包含这种转子的电动机器和压缩机。

公开(公告)号：US20220211334A1

公开(公告)日：2022-07-07

申请号：US17700442

申请日：2022-03-21

Applicant: Lars Furenlid ,  Xin Li

Inventor： Lars Furenlid ,  Xin Li

IPC: A61B6/03 ,  G01T1/202 ,  G01T1/20 ,  A61B6/00

Abstract: A scintillation-crystal based gamma-ray detector with photon sensors disposed on edge surface(s) of the crystal to take advantage of total internal reflection of scintillation photons within the thin-slab detector substrate to improve spatial resolution of determination of a scintillation event (including depth-of-interaction resolution) while preserving energy resolution and detection efficiency. The proposed structure benefits from the reduced—as compared with related art—total number of readout channels elimination of need in complicated and repetitive cutting and polishing operations to form pixelated crystal arrays used in conventional PET detector modules. Detectors systems utilizing stacks of such detectors, and methods of operation of same.

公开(公告)号：US10532963B2

公开(公告)日：2020-01-14

申请号：US16062541

申请日：2017-01-05

Applicant: SABIC Global Technologies B.V. ,  Xin Li ,  Jorge Jimenez ,  Paulette Hazin ,  Reggie Tennyson ,  Xiankuan Zhang

Inventor： Xin Li ,  Jorge Jimenez ,  Paulette Hazin ,  Reggie Tennyson ,  Xiankuan Zhang

IPC: C07C5/48 ,  B01J23/00 ,  B01J27/10 ,  C07C11/167

Abstract: Methods for producing butadiene by the oxidative dehydrogenation of butene are provided. Methods for producing butadiene from a feed stream including oxygen and butene in a molar ratio of oxygen to butene (O2/C4H8) from about 0.9 to about 1.5 can include introducing the feed stream to a catalyst in the presence of steam. The molar ratio of steam to butene (H2O/C4H8) can be from about 10 to about 20. Methods can further include reacting the butene to generate a product stream therefrom comprising butadiene and water. Methods can further include separating water from the product stream to generate a butadiene stream including greater than about 85 wt-% butadiene.

公开(公告)号：US10280649B2

公开(公告)日：2019-05-07

申请号：US15313108

申请日：2015-04-20

Applicant: Xin Li

Inventor： Xin Li

IPC: E05B47/00 ,  E05B19/00 ,  E05B73/00 ,  E05B19/26

Abstract: A magnetic unlocking device and a magnetic unlocking structure of a magnetic encoding key. The magnetic unlocking structure includes a lock core device and a magnetic unlocking device. The lock core device includes a lock core casing, a lock knob which is provided in the internal cavity of the lock core casing, a lock care front end cover and a lock core rear end cover that are located at both ends of the lock core casing. The internal wall of the lock core casing is provided with a monad longitudinal moving groove and a monad horizontal rotating groove. The lock knob is provided with an unlocking hole. The external wall of the lock knob is provided with a monad longitudinal slide-way. The monad longitudinal slide-way and the monad longitudinal moving groove correspond to each other and form a monad moving cavity.

公开(公告)号：US09991494B2

公开(公告)日：2018-06-05

申请号：US14442098

申请日：2011-07-22

Applicant: Xin Li ,  Jianhua Li ,  Wei Chen ,  Yongjun Jiao ,  Long Li ,  Xinjian Deng

Inventor： Xin Li ,  Jianhua Li ,  Wei Chen ,  Yongjun Jiao ,  Long Li ,  Xinjian Deng

IPC: H01M2/16 ,  H01M10/0525 ,  H01M2/14 ,  C08L21/00

CPC classification number: H01M2/1686 ,  B32B2457/10 ,  C08L21/00 ,  H01M2/145 ,  H01M2/1653 ,  H01M10/0525

Abstract: The present invention relates to a composite nano microporous diaphragm for use in lithium ion cells using polyolefin modified with post-crosslinked rubber and manufacturing method thereof. The microporous diaphragm at least comprises a nano microporous diaphragm A layer with a chemical gel content of more than 20%, the microscopic structure thereof is designed to be the rubber material that has been evenly dispersed and has subjected to a post-crosslinking treatment in polyolefin nano microfiber matrix, forming a nano microporous diaphragm of rubber-plastic composite. The nano microporous diaphragm with high strength, thermal cutoff, high temperature resistance, as well as good liquid absorption and swelling and compression elasticity can be applied to lithium ion power cells with high safety and long cycling life.