公开(公告)号：US08901140B2

公开(公告)日：2014-12-02

申请号：US13395892

申请日：2010-08-26

Applicant: Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

Inventor： Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

IPC: C07D401/14 ,  A61K31/4709 ,  C07F9/6512 ,  A61P35/00

CPC classification number: A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07F9/60 ,  C07F9/65128

Abstract: 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Abstract translation: 公开了6-氨基喹唑啉或3-氰基喹啉衍生物，其制备方法和药物用途。 具体地，本公开公开了通式（I）所示的新的6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变异构体，对映异构体，非对映异构体，外消旋体或其药学上可接受的盐或其代谢前体或前药， 用作特别是作为蛋白激酶抑制剂的治疗剂，其中通式（I）的每个取代基如说明书中所定义。

公开(公告)号：US20120165352A1

公开(公告)日：2012-06-28

申请号：US13395892

申请日：2010-08-26

Applicant: Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

Inventor： Peng Cho Tang ,  Xin Li ,  Bin Wang ,  Jun Wang ,  Lijun Chen

IPC: A61K31/517 ,  C07D403/12 ,  C07F9/6512 ,  A61P35/00 ,  C12N9/99 ,  C07F9/60 ,  C07D401/14 ,  A61K31/4709

CPC classification number: A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07F9/60 ,  C07F9/65128

Abstract: 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Abstract translation: 公开了6-氨基喹唑啉或3-氰基喹啉衍生物，其制备方法和药物用途。 具体地，本公开公开了通式（I）所示的新的6-氨基喹唑啉或3-氰基喹啉衍生物，或其互变异构体，对映异构体，非对映异构体，外消旋体或其药学上可接受的盐或其代谢前体或前药， 用作特别是作为蛋白激酶抑制剂的治疗剂，其中通式（I）的每个取代基如本说明书中所定义。

公开(公告)号：US09273052B2

公开(公告)日：2016-03-01

申请号：US13811957

申请日：2011-07-26

Applicant: Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

Inventor： Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

IPC: A61K31/495 ,  C07D487/04 ,  A61K31/502 ,  A61K45/00 ,  A61K31/4188

CPC classification number: A61K31/502 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/5377 ,  A61K45/00 ,  C07D487/04 ,  A61K2300/00

Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

Abstract translation: 描述由式（I）表示的酞嗪酮酮衍生物，其制备方法，含有该衍生物的药物组合物，其作为聚（ADP-核糖）聚合酶（PARP）抑制剂的用途及其癌症治疗方法。

公开(公告)号：US20130338190A1

公开(公告)日：2013-12-19

申请号：US14001778

申请日：2012-02-10

Applicant: Xin Li ,  Bin Wang

Inventor： Xin Li ,  Bin Wang

IPC: C07D401/14 ,  C07C57/13 ,  C07C309/04 ,  C07C57/145 ,  C07C309/30

CPC classification number: C07D401/14 ,  A61K31/4709 ,  C07C57/13 ,  C07C57/145 ,  C07C309/04 ,  C07C309/30

Abstract: Provided as represented by formula (I) is a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide, a preparation method thereof, and a use thereof as a therapeutic agent, and especially as a protein kinase inhibitor.

Abstract translation: 由式（I）表示的是（E）-N- [4 - [[3-氯-4-（2-吡啶基甲氧基）苯基]氨基] -3-氰基-7-乙氧基-6 - 喹啉基] -3 - [（2R）-1-甲基吡咯烷-2-基]丙-2-烯酰胺，其制备方法及其作为治疗剂的用途，特别是作为蛋白激酶抑制剂。

公开(公告)号：US20130131068A1

公开(公告)日：2013-05-23

申请号：US13811957

申请日：2011-07-26

Applicant: Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

Inventor： Peng Cho Tang ,  Xin Li ,  Xiangqin Li ,  Yang Chen ,  Bin Wang ,  Zhe Zhu

IPC: C07D487/04 ,  A61K45/00 ,  A61K31/502

CPC classification number: A61K31/502 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/5377 ,  A61K45/00 ,  C07D487/04 ,  A61K2300/00

Abstract: A phthalazinone ketone derivative as represented by formula (I), a preparation method thereof, a pharmaceutical composition containing the derivative, a use thereof as a poly (ADP-ribose) polymerase (PARP) inhibitor, and a cancer treatment method thereof are described.

Abstract translation: 描述由式（I）表示的酞嗪酮酮衍生物，其制备方法，含有该衍生物的药物组合物，其作为聚（ADP-核糖）聚合酶（PARP）抑制剂的用途及其癌症治疗方法。

公开(公告)号：USD956306S1

公开(公告)日：2022-06-28

申请号：US29769045

申请日：2021-02-03

Applicant: Bin Wang

Designer： Bin Wang

公开(公告)号：US09975967B2

公开(公告)日：2018-05-22

申请号：US13409735

申请日：2012-03-01

Applicant: Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

Inventor： Charles Michael Buchanan ,  Michael Eugene Donelson ,  Elizabeth Guzman-Morales ,  Peter Borden Mackenzie ,  Bin Wang

IPC: G02F1/1335 ,  C08B3/16 ,  C08J5/18 ,  C08L1/14 ,  G02B1/04 ,  C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  G02F1/13363

CPC classification number: C08B3/16 ,  B32B2457/202 ,  C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  C08J5/18 ,  C08J2301/14 ,  C08L1/14 ,  G02B1/04 ,  G02F1/13363 ,  G02F2001/133631 ,  Y10T428/10 ,  Y10T428/1036 ,  Y10T428/105

Abstract: Regioselectively substituted cellulose esters having a plurality of aryl-acyl substituents and a plurality of alkyl-acyl substituents are disclosed along with methods for making the same. Such cellulose esters may be suitable for use in optical films, such as optical films having certain Nz values, −A optical films, and/or +C optical films. Optical films prepared employing such cellulose esters have a variety of commercial applications, such as, for example, as compensation films in liquid crystal displays and/or waveplates in creating circular polarized light used in 3-D technology.

公开(公告)号：US09956340B2

公开(公告)日：2018-05-01

申请号：US14307063

申请日：2014-06-17

Applicant: Bin Wang ,  Jason Shih ,  Gregory Harbers ,  Fukang Jiang ,  Sean Caffey

Inventor： Bin Wang ,  Jason Shih ,  Gregory Harbers ,  Fukang Jiang ,  Sean Caffey

IPC: A61M5/155 ,  A61M31/00 ,  A61L31/14 ,  A61L31/04 ,  A61M5/142 ,  A61M5/145

CPC classification number: A61M5/155 ,  A61L31/048 ,  A61L31/14 ,  A61M5/14212 ,  A61M5/14276 ,  A61M5/14593 ,  A61M31/002 ,  A61M2005/14204

Abstract: An implantable device has an outer shell that includes an aperture through the housing of the device and, spanning the aperture, a membrane structure permeable to gas but not to liquid. In this way, excess gas may be vented from the device. The membrane and aperture are designed to discourage or even prevent tissue ingrowth.

公开(公告)号：US09917874B2

公开(公告)日：2018-03-13

申请号：US12887483

申请日：2010-09-21

Applicant: Michael G. Luby ,  Mark Watson ,  Payam Pakzad ,  Bin Wang

Inventor： Michael G. Luby ,  Mark Watson ,  Lorenzo Vicisano ,  Payam Pakzad ,  Bin Wang

IPC: G06F15/16 ,  H04L29/06 ,  H04N21/231 ,  H04N21/234 ,  H04N21/2343 ,  H04N21/235 ,  H04N21/258 ,  H04N21/2662 ,  H04N21/435 ,  H04N21/44 ,  H04N21/4402 ,  H04N21/442 ,  H04N21/84 ,  H04N21/845 ,  H04N21/24

CPC classification number: H04L65/604 ,  H04L65/4084 ,  H04L65/602 ,  H04L65/607 ,  H04L65/80 ,  H04N21/23106 ,  H04N21/23406 ,  H04N21/234327 ,  H04N21/235 ,  H04N21/2401 ,  H04N21/25808 ,  H04N21/2662 ,  H04N21/435 ,  H04N21/44004 ,  H04N21/440227 ,  H04N21/44209 ,  H04N21/84 ,  H04N21/8456

Abstract: A block-request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server. A client device can be adapted to take advantage of the ingestion process. The client device might be configured to optimize use of resources, given the information available to it from the ingestion system. This may include configurations to determine the sequence, timing and construction of block requests based on monitoring buffer size and rate of change of buffer size, use of variable sized requests, mapping of block requests to underlying transport connections, flexible pipelining of requests, and/or use of whole file requests based on statistical considerations.

公开(公告)号：USRE46742E1

公开(公告)日：2018-02-27

申请号：US14565013

申请日：2014-12-09

Applicant: Bin Wang ,  Zijiang Ma ,  Hui Xu ,  Wei Gou

Inventor： Bin Wang ,  Zijiang Ma ,  Hui Xu ,  Wei Gou

IPC: H04W4/06 ,  H04W48/08

CPC classification number: H04W4/06 ,  H04W48/08

Abstract: The present invention discloses a method for obtaining a service list and multimedia broadcast multicast service data, and the method includes: obtaining electronic service guide (ESG) information, receiving a system information block (SIB)13 from system information, and obtaining a cell service list according to the ESG information and the SIB 13. The present invention also discloses a system for obtaining a service list and multimedia broadcast multicast service data; in the system, a cell service list acquisition unit is configured to obtain ESG information, receive an SIB 13 from system information, and obtain a cell service list according to the ESG information and the SIB 13. With the method and system in the present invention, the cell service list can be acquired, and the receiving of data of multimedia broadcast multicast service (MBMS) service can be achieved after obtaining the cell service list.