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公开(公告)号：US5731463A
公开(公告)日：1998-03-24
申请号：US717381
申请日：1996-09-23
申请人： Xiu C. Wang , Ashok V. Bhatia , Steven Chamberlin , Luping Liu
发明人： Xiu C. Wang , Ashok V. Bhatia , Steven Chamberlin , Luping Liu
IPC分类号： C07C213/04 , C07C41/16 , C07C43/178 , C07C213/06 , C07C217/32 , C07C217/34 , C07C209/02
CPC分类号： C07C41/16 , C07C213/06 , C07D303/23 , C07C2101/02
摘要： The present invention relates to a process for the selective alkylation of intermediates of betaxolol.
摘要翻译： 本发明涉及一种选择性烷基化倍他洛尔中间体的方法。
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公开(公告)号：US5942633A
公开(公告)日：1999-08-24
申请号：US667038
申请日：1996-06-19
申请人： Xiu C. Wang , Luping Liu , Ashok V. Bhatia
发明人： Xiu C. Wang , Luping Liu , Ashok V. Bhatia
IPC分类号： C07C213/04 , C07D301/00 , C07D303/22 , C07D303/24 , C07D303/18 , C07D93/06
CPC分类号： C07D301/00 , C07C213/04 , C07D303/24
摘要： The present invention relates to a process for the selective alkylation of intermediates of betaxolol.
摘要翻译： 本发明涉及一种选择性烷基化倍他洛尔中间体的方法。
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公开(公告)号：US07410992B2
公开(公告)日：2008-08-12
申请号：US10569921
申请日：2004-08-31
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。
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公开(公告)号：US07196082B2
公开(公告)日：2007-03-27
申请号：US10684990
申请日：2003-10-14
IPC分类号： A61K31/5375 , A61K31/44 , A61K31/416 , C07D231/56 , C07D413/06
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20050256117A1
公开(公告)日：2005-11-17
申请号：US10511636
申请日：2003-06-11
申请人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
发明人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
IPC分类号： A61K9/08 , A61K9/10 , A61K31/404 , A61K31/41 , A61K31/427 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K45/00 , A61K47/36 , A61P3/10 , A61P9/06 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P43/00 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/18 , C07D401/06 , C07D403/10 , C07D409/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D417/14 , C07H15/26 , C07D43/02
CPC分类号： C07D401/06 , C07D209/12 , C07D209/18 , C07D403/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07H15/26
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20070129418A1
公开(公告)日：2007-06-07
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20060148805A1
公开(公告)日：2006-07-06
申请号：US10561571
申请日：2004-06-25
申请人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
发明人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
IPC分类号： A61K31/522 , A61K31/503 , A61K31/498 , A61K31/4184 , C07D473/10 , C07D471/02 , C07D487/02
CPC分类号： C07D235/12 , C07D235/08 , C07D235/16 , C07D405/04 , C07D471/04
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US07547720B2
公开(公告)日：2009-06-16
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US07494983B2
公开(公告)日：2009-02-24
申请号：US10570231
申请日：2004-08-31
IPC分类号： A61K31/675 , A61K31/4439 , C07F9/06
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及结构式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20070027188A1
公开(公告)日：2007-02-01
申请号：US10570231
申请日：2004-08-31
申请人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
发明人： Meng Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Robert Tynebor
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及结构式I的有效钾通道阻断剂化合物或其用于治疗青光眼的其它制剂及导致患者眼睛中眼内压升高的其它病症本发明还涉及这些化合物在使用中提供 对哺乳动物物种，特别是人类的眼睛的神经保护作用。
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