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42 条记录 (耗时 0.04 秒)

    Ophthalmic compositions for treating ocular hypertension
    1.
    发明授权
    Ophthalmic compositions for treating ocular hypertension 有权
    用于治疗高眼压症的眼用组合物

    公开(公告)号：US07410992B2

    公开(公告)日：2008-08-12

    申请号：US10569921

    申请日：2004-08-31

    申请人： Meng Hsin Chen ,  James B. Doherty ,  Luping Liu ,  Swaminathan Natarajan ,  Robert M. Tynebor

    发明人： Meng Hsin Chen ,  James B. Doherty ,  Luping Liu ,  Swaminathan Natarajan ,  Robert M. Tynebor

    IPC分类号： A61K31/416 ,  C07D231/54

    CPC分类号： C07D401/06 ,  C07F9/65038 ,  C07F9/65583

    摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).

    摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。

    P38 kinase inhibiting agents
    7.
    发明授权
    P38 kinase inhibiting agents 有权
    P38激酶抑制剂

    公开(公告)号：US07879875B2

    公开(公告)日：2011-02-01

    申请号：US11990050

    申请日：2006-08-08

    申请人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor ,  Swaminathan R. Natarajan ,  Zhen Li ,  Soumya P. Sahoo

    发明人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor ,  Swaminathan R. Natarajan ,  Zhen Li ,  Soumya P. Sahoo

    IPC分类号： A61K31/4375 ,  C07D455/02

    CPC分类号： C07D471/04

    摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

    摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

    P38 Kinase Inhibiting Agents
    8.
    发明申请
    P38 Kinase Inhibiting Agents 审中-公开
    P38激酶抑制剂

    公开(公告)号：US20090088436A1

    公开(公告)日：2009-04-02

    申请号：US12085419

    申请日：2006-12-01

    申请人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor

    发明人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor

    IPC分类号： A61K31/502 ,  C07D237/26 ,  A61P35/00

    CPC分类号： C07D455/02 ,  C07D471/04

    摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

    摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。

    P38 Kinase Inhibiting Agents
    10.
    发明申请
    P38 Kinase Inhibiting Agents 有权
    P38激酶抑制剂

    公开(公告)号：US20090131472A1

    公开(公告)日：2009-05-21

    申请号：US11990050

    申请日：2006-08-08

    申请人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor ,  Swaminathan R. Natarajan ,  Zhen Li ,  Soumya P. Sahoo

    发明人： Meng-Hsin Chen ,  James B. Doherty ,  Robert Tynebor ,  Swaminathan R. Natarajan ,  Zhen Li ,  Soumya P. Sahoo

    IPC分类号： A61K31/4375 ,  C07D455/02 ,  A61P37/02

    CPC分类号： C07D471/04

    摘要： Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

    摘要翻译： 由化学式（I）或其药学上可接受的盐描述的化合物：（I）是p38的抑制剂，可用于治疗炎症，例如治疗类风湿性关节炎，类风湿性脊椎炎，骨关节炎，痛风性关节炎和其他关节炎病症 ; 发炎关节，湿疹，牛皮癣或其他炎症皮肤病如晒伤; 炎症性眼病，包括结膜炎; 皮肤炎，疼痛等与炎症有关的病症。