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公开(公告)号：US07196082B2
公开(公告)日：2007-03-27
申请号：US10684990
申请日：2003-10-14
IPC分类号： A61K31/5375 , A61K31/44 , A61K31/416 , C07D231/56 , C07D413/06
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US07528163B2
公开(公告)日：2009-05-05
申请号：US10530840
申请日：2003-11-04
申请人： James B. Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan R. Natarajan , Dong-Ming Shen , Robert M. Tynebor
发明人： James B. Doherty , Meng-Hsin Chen , Luping Liu , Swaminathan R. Natarajan , Dong-Ming Shen , Robert M. Tynebor
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D417/14 , C07D231/56 , C07D401/06 , C07D403/06 , C07D417/12
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US07547720B2
公开(公告)日：2009-06-16
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US07410992B2
公开(公告)日：2008-08-12
申请号：US10569921
申请日：2004-08-31
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。
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公开(公告)号：US07494983B2
公开(公告)日：2009-02-24
申请号：US10570231
申请日：2004-08-31
IPC分类号： A61K31/675 , A61K31/4439 , C07F9/06
CPC分类号： C07D401/06
摘要： This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及结构式I的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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6.发明授权(Halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents 失效（卤 - 苯并羰基）杂环稠合苯基p38激酶抑制剂公开(公告)号：US06809199B2
公开(公告)日：2004-10-26
申请号：US10023231
申请日：2001-12-17
申请人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
发明人： James B. Doherty , John E. Stelmach , Meng-Hsin Chen , Luping Liu , Julianne A. Hunt , Rowena D. Ruzck , Joung L. Goulet , David D. Wisnoski , Swaminathan Ravi Natarajan , Kathleen M. Rupprecht , Jianming Bao , Shouwu Miao , Xingfang Hong , Peter J. Sinclair , Florida Kallashi
IPC分类号： C07D23972
CPC分类号： C07D215/227 , C07D221/06 , C07D231/12 , C07D233/56 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D409/14 , C07D417/12 , C07D451/02 , C07D471/04 , C07D487/08
摘要： Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof: are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
摘要翻译： 由化学式（I）表示的化合物或其药学上可接受的盐是可用于治疗炎性疾病如关节炎的p38的抑制剂。
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公开(公告)号：US20050256117A1
公开(公告)日：2005-11-17
申请号：US10511636
申请日：2003-06-11
申请人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
发明人： Meng Hsin Chen , Luping Liu , Peter Meinke , Ravi Natarajan , William Parsons , Dong-Ming Shen , Min Shu , John Stelmach , Harold Wood , Fengqi Zhang , David Wisnoski , James Doherty
IPC分类号： A61K9/08 , A61K9/10 , A61K31/404 , A61K31/41 , A61K31/427 , A61K31/4439 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/7056 , A61K45/00 , A61K47/36 , A61P3/10 , A61P9/06 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P43/00 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/18 , C07D401/06 , C07D403/10 , C07D409/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D417/14 , C07H15/26 , C07D43/02
CPC分类号： C07D401/06 , C07D209/12 , C07D209/18 , C07D403/10 , C07D409/12 , C07D417/12 , C07D417/14 , C07H15/26
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20070129418A1
公开(公告)日：2007-06-07
申请号：US11641212
申请日：2006-12-19
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07F9/65038 , C07D231/56
摘要： This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：US20060148805A1
公开(公告)日：2006-07-06
申请号：US10561571
申请日：2004-06-25
申请人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
发明人： Meng Hsin Chen , James Doherty , Luping Liu , Swaminathan Natarajan , Dong-Ming Shen , Min Shu
IPC分类号： A61K31/522 , A61K31/503 , A61K31/498 , A61K31/4184 , C07D473/10 , C07D471/02 , C07D487/02
CPC分类号： C07D235/12 , C07D235/08 , C07D235/16 , C07D405/04 , C07D471/04
摘要： This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
摘要翻译： 本发明涉及有效的钾通道阻滞剂或其制剂在治疗青光眼和导致患者眼睛中眼内压升高的其它病症中的用途。 本发明还涉及这些化合物对哺乳动物物种尤其是人的眼睛的神经保护作用的用途。
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公开(公告)号：US20070010491A1
公开(公告)日：2007-01-11
申请号：US10569921
申请日：2004-08-31
IPC分类号： A61K31/4439 , A61K31/675
CPC分类号： C07D401/06 , C07F9/65038 , C07F9/65583
摘要： This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents C6-10 aryl or C3-10 heterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from Ra; Z represents (CH2)nPO(OR)(OR*).
摘要翻译： 本发明涉及式（I）的有效钾通道阻断剂化合物或其制剂用于治疗青光眼和导致患者眼睛中眼内压升高的其它病症。 本发明还涉及这些化合物对哺乳动物物种，特别是人类或其药学上可接受的盐，体内可水解的酯，对映异构体，非对映体或其混合物的眼睛的神经保护作用的用途：式（II） 所述芳基或杂环基任选被1-3个选自R a，R b，R 3，R 3，R 3， Z表示（CH 2）n PO（OR）（OR *）。
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