公开(公告)号：US11002735B2

公开(公告)日：2021-05-11

申请号：US16748001

申请日：2020-01-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G16B40/00 ,  G01N33/564 ,  G16B20/00 ,  G01N33/68

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

公开(公告)号：US20170016895A1

公开(公告)日：2017-01-19

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/68

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

Abstract translation: 提供用于诊断受试者系统性红斑狼疮（SLE）的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中SLE的特异性寡核苷酸抗体反应性。

公开(公告)号：US20140315740A1

公开(公告)日：2014-10-23

申请号：US14320530

申请日：2014-06-30

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Irun R. Cohen ,  Francisco Javier Quintana ,  Eytan Domany ,  Gad Elizur ,  Peter H. Hagedorn

IPC: G01N33/564

CPC classification number: G01N33/564

Abstract: A method of diagnosing an immune disease, or a predisposition thereto, in a subject is disclosed. The method comprises determining a capacity of immunoglobulins of the subject to specifically bind each antigen probe of an antigen probe set, wherein the antigen probe set comprises a plurality of antigen probes selected from the group consisting of at least a portion of a cell/tissue structure molecule, at least a portion of a heat shock protein, at least a portion of an immune system molecule, at least a portion of a homopolymeric polypeptide, at least a portion of a hormone, at least a portion of a metabolic enzyme, at least a portion of a microbial antigen, at least a portion of a molluscan antigen, at least a portion of a nucleic acid, at least a portion of a plant antigen, at least a portion of plasma molecule, and at least a portion of a tissue antigen, wherein the capacity is indicative of the immune disease or the predisposition thereto, thereby diagnosing the immune disease, or the predisposition thereto, in the subject.

Abstract translation: 公开了一种在受试者中诊断免疫疾病或其倾向的方法。 该方法包括确定受试者的免疫球蛋白的能力以特异性结合抗原探针组的每个抗原探针，其中所述抗原探针组包含多个选自下组的抗原探针：至少一部分细胞/组织结构 分子，至少一部分热休克蛋白，至少一部分免疫系统分子，至少一部分均聚多肽，至少一部分激素，代谢酶的至少一部分，至少 一部分微生物抗原，至少一部分软体动物素抗原，至少一部分核酸，至少一部分植物抗原，至少一部分血浆分子和至少一部分组织 抗原，其中所述能力指示免疫疾病或其易感性，从而诊断受试者的免疫疾病或其易感性。

公开(公告)号：US11846636B2

公开(公告)日：2023-12-19

申请号：US16751831

申请日：2020-01-24

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/53 ,  G01N33/564 ,  C12Q1/6883 ,  A61K31/711

CPC classification number: G01N33/564 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5308 ,  G01N2800/104

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US20140200159A1

公开(公告)日：2014-07-17

申请号：US14210409

申请日：2014-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G01N33/564

CPC classification number: G01N33/564 ,  G01N33/6803 ,  G06F19/18 ,  G06F19/24

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

Abstract translation: 用于聚类的方法，系统和制品，从而鉴定与需要诊断疾病或监测治疗的患者受试者的血清的未确定免疫球蛋白反应的预定义抗原。

公开(公告)号：US10082503B2

公开(公告)日：2018-09-25

申请号：US14210409

申请日：2014-03-13

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G06F19/24 ,  G01N33/564 ,  G01N33/68 ,  G06F19/18

CPC classification number: G01N33/564 ,  G01N33/6803 ,  G16B20/00 ,  G16B40/00

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

公开(公告)号：US10545144B2

公开(公告)日：2020-01-28

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/6883

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US20160320384A1

公开(公告)日：2016-11-03

申请号：US15107483

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C07K14/705 ,  A61K38/13 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/564 ,  A61K38/00 ,  A61K38/13 ,  C07K14/70521 ,  C07K2319/30 ,  C12N2310/17 ,  C12Q1/6804 ,  G01N33/6854 ,  G01N2800/245 ,  G01N2800/52

Abstract: A method of assaying or monitoring the determining immunological competence of a subject, particularly for determining immunological competence in a subject, including but not limited to a transplant recipient, is provided. The method comprises measuring the levels of antibodies in a sample obtained from a subject to poly-guanine oligonucleotides.

Abstract translation: 提供了测定或监测受试者的测定免疫学能力的方法，特别是用于确定受试者的免疫学能力，包括但不限于移植受体。 该方法包括测量从受试者获得的样品中的聚鸟嘌呤寡核苷酸的抗体水平。