公开(公告)号：US20170016895A1

公开(公告)日：2017-01-19

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/68

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

Abstract translation: 提供用于诊断受试者系统性红斑狼疮（SLE）的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中SLE的特异性寡核苷酸抗体反应性。

公开(公告)号：US11846636B2

公开(公告)日：2023-12-19

申请号：US16751831

申请日：2020-01-24

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/53 ,  G01N33/564 ,  C12Q1/6883 ,  A61K31/711

CPC classification number: G01N33/564 ,  A61K31/711 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5308 ,  G01N2800/104

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US10545144B2

公开(公告)日：2020-01-28

申请号：US15108889

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C12Q1/6883

Abstract: Methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject are provided. Particularly, the present invention relates to specific oligonucleotide antibody reactivities useful in diagnosing SLE in a subject.

公开(公告)号：US20160320384A1

公开(公告)日：2016-11-03

申请号：US15107483

申请日：2014-12-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Noam Shental ,  Ittai Fattal

IPC: G01N33/564 ,  C07K14/705 ,  A61K38/13 ,  C12Q1/68 ,  G01N33/68

CPC classification number: G01N33/564 ,  A61K38/00 ,  A61K38/13 ,  C07K14/70521 ,  C07K2319/30 ,  C12N2310/17 ,  C12Q1/6804 ,  G01N33/6854 ,  G01N2800/245 ,  G01N2800/52

Abstract: A method of assaying or monitoring the determining immunological competence of a subject, particularly for determining immunological competence in a subject, including but not limited to a transplant recipient, is provided. The method comprises measuring the levels of antibodies in a sample obtained from a subject to poly-guanine oligonucleotides.

Abstract translation: 提供了测定或监测受试者的测定免疫学能力的方法，特别是用于确定受试者的免疫学能力，包括但不限于移植受体。 该方法包括测量从受试者获得的样品中的聚鸟嘌呤寡核苷酸的抗体水平。