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1.发明申请公开(公告)号：US20190048053A1
公开(公告)日：2019-02-14
申请号：US16074086
申请日：2017-02-03
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Varda ROTTER , Moshe OREN , Perry TAL , Shay EIZENBERGER , Avi BEN-SHIMON
Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
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Patent Agency Ranking
公开(公告)号：US20230127559A1
公开(公告)日：2023-04-27
申请号：US17911277
申请日：2021-03-15
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Varda ROTTER , Moshe OREN , Perry TAL , Fernando ALBERICIO
Abstract: Peptide analogs which are endowed with the property of at least partially reactivating a mutant p53 protein are provided. Also provided are uses thereof in the treatment of diseases associated with mutant p53.
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公开(公告)号：US20180057533A1
公开(公告)日：2018-03-01
申请号：US15796811
申请日：2017-10-29
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Moshe OREN , Varda ROTTER , Perry TAL
CPC classification number: C07K7/06 , A61K38/00 , A61K38/08 , A61K38/16 , C07K7/08 , C07K14/00 , C07K14/4746
Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
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公开(公告)号：US20220251159A1
公开(公告)日：2022-08-11
申请号：US17549369
申请日：2021-12-13
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD
Inventor： Varda ROTTER , Moshe OREN , Perry TAL , Shay EIZENBERGER , Avi BEN-SHIMON
Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
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公开(公告)号：US20200095282A1
公开(公告)日：2020-03-26
申请号：US16704010
申请日：2019-12-05
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Moshe OREN , Varda ROTTER , Perry TAL
Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
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公开(公告)号：US20190315804A1
公开(公告)日：2019-10-17
申请号：US16451081
申请日：2019-06-25
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Moshe OREN , Varda ROTTER , Perry TAL
Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
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