公开(公告)号：US20240148845A1

公开(公告)日：2024-05-09

申请号：US18515358

申请日：2023-11-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  A61K39/395 ,  A61P31/00 ,  A61P35/04 ,  C07K16/28 ,  C12N5/078 ,  C12N5/0783

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  A61K2035/122 ,  A61K2039/5158 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/30

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20180207247A1

公开(公告)日：2018-07-26

申请号：US15744881

申请日：2016-07-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/0783

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61K2035/122 ,  A61K2039/5158 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/467

Abstract: A method of transplantation is disclosed. The method comprising administering to a subject in need of transplantation of cells in suspension, a therapeutically effective amount of anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, said anti-third party cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, wherein said cells in suspension comprise non-hematopoietic cells or hematopoietic cells which are not stem cells. Methods of treating and kits are also provided.

公开(公告)号：US20160354410A1

公开(公告)日：2016-12-08

申请号：US15242666

申请日：2016-08-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Assaf LASK ,  Eran OPHIR ,  Noga OR-GEVA ,  Adva COHEN ,  Ran AFIK ,  Esther BACHAR-LUSTIG ,  Yaki EIDELSTEIN

IPC: A61K35/17 ,  A61K35/28 ,  C12N5/0783 ,  A61K45/06

CPC classification number: A61K35/17 ,  A61K31/517 ,  A61K35/28 ,  A61K39/001 ,  A61K45/06 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0602 ,  C12N5/0636 ,  C12N5/0637 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  A61K2300/00

Abstract: A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.

公开(公告)号：US20230024587A1

公开(公告)日：2023-01-26

申请号：US17735146

申请日：2022-05-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Yaki EIDELSTEIN ,  Eran OPHIR ,  Assaf LASK ,  Ran AFIK ,  Noga OR-GEVA ,  Esther BACHAR-LUSTIG

IPC: A61K35/17 ,  A61K39/00 ,  C12N5/0783 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US20180193384A1

公开(公告)日：2018-07-12

申请号：US15825275

申请日：2017-11-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Yaki EIDELSTEIN ,  Eran OPHIR ,  Assaf LASK ,  Ran AFIK ,  Noga OR-GEVA ,  Esther BACHAR-LUSTIG

IPC: A61K35/17 ,  A61K39/00 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  C12N5/0783 ,  A61K35/22 ,  A61K35/42 ,  A61K35/407 ,  A61K35/12

CPC classification number: A61K35/17 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K39/001 ,  A61K2035/122 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N5/0637 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2502/1121

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US20220080034A1

公开(公告)日：2022-03-17

申请号：US17531897

申请日：2021-11-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/00 ,  A61K35/17 ,  C12N5/078 ,  C12N5/0783 ,  A61P31/00 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20180207272A1

公开(公告)日：2018-07-26

申请号：US15744905

申请日：2016-07-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Noga OR-GEVA ,  Eran OPHIR ,  Yaki EIDELSTEIN ,  Rotem GIDRON BUDOVSKY

IPC: A61K39/395 ,  C07K16/28 ,  A61P31/00 ,  A61P35/04

CPC classification number: A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61K2035/122 ,  A61K2039/5158 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/467

Abstract: An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.