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公开(公告)号：US5080796A
公开(公告)日：1992-01-14
申请号：US478624
申请日：1990-02-12
CPC分类号： A61M1/369 , A61M1/3472 , A61M1/3482 , B01D61/18 , B01D2313/22 , B01D2313/38 , Y10S210/905 , Y10S210/908
摘要： A method for more selectively removing macromolecules from a plasma solution, whereby plasma containing the macromolecules to be removed is provided and heated to a temperature near or above normal body temperature but below the boiling point of the plasma solution. The heated plasma solution is filtered while at a temperature near or above normal body temperature but below its boiling point with a membrane filter to remove selectively macromolecules from the plasma solution. An apparatus for accomplishing the foregoing is also provided.
摘要翻译： 一种用于从血浆溶液中更有选择地除去大分子的方法，由此提供含有要除去的大分子的等离子体并将其加热至接近或高于正常体温但低于等离子体溶液的沸点的温度。 加热的等离子体溶液在温度接近或高于正常体温但低于其沸点的同时用膜过滤器过滤以从血浆溶液中选择性地除去大分子。 还提供了一种用于实现前述的装置。
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公开(公告)号：US4966709A
公开(公告)日：1990-10-30
申请号：US220919
申请日：1988-07-18
CPC分类号： A61M1/369 , A61M1/3472 , A61M1/3482 , B01D61/14 , B01D2313/22 , Y10S210/905 , Y10S210/908
摘要： A method for more selectively removing macromolecules from a plasma solution, whereby plasma containing the macromolecules to be removed is provided and heated to a temperature near or above normal body temperature but below the boiling point of the plasma solution. The heated plasma solution is filtered while at a temperature near or above normal body temperature but below its boiling point with a membrane filter to remove selectively macromolecules from the plasma solution. An apparatus for accomplishing the foregoing is also provided.
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公开(公告)号：US4128479A
公开(公告)日：1978-12-05
申请号：US871019
申请日：1978-01-20
申请人： Paul S. Malchesky , Yukihiko Nose
发明人： Paul S. Malchesky , Yukihiko Nose
IPC分类号： A61M1/22 , A61M20060101 , A61M1/16 , A61M1/24 , B01D31/00
CPC分类号： B01D63/10 , B01D2313/02
摘要： A unit is presented for the transfer of a gaseous component in one stream to or from a liquid component in another stream, in which a membrane assembly is wound spirally around a central rigid cylindrical core. The membrane assembly comprises a continuous length of flattened tubular membrane with a gas net passing through the intermediate portion of the membrane from end to end thereof and substantially the width of the interior of the tubular membrane. In forming the coil, a net separator is wound between the membrane layers of the coil. An inlet tube for one of the components communicates with one end of the membrane and an outlet tube for the same component communicates with the other end of the membrane. Means is provided for passing another of the components longitudinally of the coil between the membrane layers from one end of the coil to the other end. The specific embodiment of a blood oxygenator is described.
摘要翻译： 提供了一个单元，用于将一个气流中的气体组分转移到另一个流中的液体组分或从另一个流中的液体组分转移，其中膜组件围绕中心刚性圆柱形芯螺旋缠绕。 膜组件包括连续长度的扁平管状膜，其中气网从端部到端部穿过膜的中间部分，并且基本上是管状膜内部的宽度。 在形成线圈时，网状隔膜缠绕在线圈的膜层之间。 用于其中一个部件的入口管与膜的一端连通，并且用于相同部件的出口管与膜的另一端连通。 提供了用于将线圈纵向的另一个部件从线圈的一端到另一端的膜层之间通过的装置。 描述了血液充氧器的具体实施例。
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公开(公告)号：US4619639A
公开(公告)日：1986-10-28
申请号：US775097
申请日：1985-09-11
申请人： Yukihiko Nose , Paul S. Malchesky
发明人： Yukihiko Nose , Paul S. Malchesky
CPC分类号： A61K35/16 , A61M1/3486 , B01D61/147 , B01D63/02 , B01D2313/243 , B01D2313/44 , Y10S210/929
摘要： A method and apparatus for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a range up to just below 50 mm Hg. This provides an increased flow as compared to the flow obtained with higher pressures.
摘要翻译： 一种用于从全血中分离血浆的方法和装置，其中全血通过过滤膜，适合于从全血中分离血浆并具有0.1至0.6微米的孔径的正极压差 该膜的范围高达低于50 mm Hg。 与通过较高压力获得的流量相比，这提供了增加的流量。
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公开(公告)号：US4311587A
公开(公告)日：1982-01-19
申请号：US102140
申请日：1979-12-10
申请人： Yukihiko Nose , Paul S. Malchesky
发明人： Yukihiko Nose , Paul S. Malchesky
CPC分类号： A61M1/28 , A61M1/1672 , A61M1/281 , A61M2202/203
摘要： A filter connection for peritoneal dialysis is presented including, in a flow line from a source of fresh dialysate solution carried on the patient's body, and under pressure, through a bacteria filter of sub-micron porosity for removing microorganisms generally greater than about 0.2 microns (nominal size) together with tubular connections leading from the filter toward a catheter inserted in the patient's peritoneum including in order from the filter, a first check valve permitting flow only away from the filter, then an outflow port with check valve permitting used dialysis flow only away from the patient, and finally the connection to the catheter tube.
摘要翻译： 提供了用于腹膜透析的过滤器连接，其包括在来自患者身体上携带的新鲜透析液的来源的流动管线中并且在压力下通过用于除去通常大于约0.2微米的微生物的亚微米孔隙率的细菌过滤器（ 公称尺寸）以及从过滤器引导到插入患者腹膜的导管的管状连接，包括从过滤器开始的顺序，第一止回阀仅允许流过过滤器，然后仅具有允许仅使用透析流的止回阀的流出口 远离病人，最后连接到导管。
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公开(公告)号：US4897162A
公开(公告)日：1990-01-30
申请号：US151622
申请日：1988-02-02
IPC分类号： G01N27/48
CPC分类号： G01N27/3271
摘要： A glucose sensing apparatus and method includes an electrocatalytic sensor having a reference electrode and a sensing electrode. A periodic signal is comprised of a ramp voltage which is intermingled a series of square wave measurement pulses. This signal is applied to the sensor. Current levels are sampled twice during each measurement pulse, and a signal indicative of glucose level is derived therefrom. After completion of a measurement, a reactivation, signal is applied to the electrode to regenerate deteriorated surfaces thereof.
摘要翻译： 葡萄糖感测装置和方法包括具有参考电极和感测电极的电催化传感器。 周期信号由斜波电压组成，该斜坡电压混合了一系列方波测量脉冲。 该信号被施加到传感器。 在每个测量脉冲期间对电流电平进行两次采样，并从其中得到指示葡萄糖水平的信号。 在测量完成之后，再次激活信号被施加到电极以再生其劣化的表面。
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公开(公告)号：US4402940A
公开(公告)日：1983-09-06
申请号：US418551
申请日：1982-09-17
申请人： Yukihiko Nose , Koji Kayashima , Akinori Sueoka , Yoshihiro Asanuma , Shigeru Shinagawa , James Smith , Andrej Werynski , Paul S. Malchesky
发明人： Yukihiko Nose , Koji Kayashima , Akinori Sueoka , Yoshihiro Asanuma , Shigeru Shinagawa , James Smith , Andrej Werynski , Paul S. Malchesky
CPC分类号： B01D69/08 , A61K35/16 , A61M1/3472 , A61M1/3482 , B01D69/02
摘要： This invention provides a method for treating blood plasma wherein a hollow fiber membrane which comprises at least a skin layer on one surface of the membrane and also a porous layer inside the membrane is employed. The skin layer of the membrane has micropores with average pore size of 50 to 450 A, and the membrane shows a water permeability of 80 ml/m.sup.2.hr.mmHg or more, and permeabilites for human blood plasma albumin of 85% or more and for human blood plasma immunoglobulin G(IgG) of 80% or more, and a rate of inhibition against human blood plasma immunoglobulin M(IgM) of 40% or more. Use of the above mentioned hollow fiber membrane, which makes it possible to selectively remove immune complex, rheumatoid factors, etc., without decrease in levels of immunological functions, brings excellent effects on therapy of autoimmune diseases.
摘要翻译： 本发明提供了一种治疗血浆的方法，其中采用在膜的一个表面上至少包含皮肤层以及膜内的多孔层的中空纤维膜。 膜的表层具有平均孔径为50〜450A的微孔，膜的透水性为80ml / m 2·hr·mmHg以上，透血性为85％以上的人血浆白蛋白， 对于80％以上的人血浆免疫球蛋白G（IgG），对人血浆免疫球蛋白M（IgM）的抑制率为40％以上。 使用上述中空纤维膜，这使得可以选择性地除去免疫复合物，类风湿因子等而不降低免疫功能水平，对自身免疫性疾病的治疗带来极好的效果。
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公开(公告)号：US4381775A
公开(公告)日：1983-05-03
申请号：US179224
申请日：1980-08-18
申请人： Yukihiko Nose' , Paul S. Malchesky
发明人： Yukihiko Nose' , Paul S. Malchesky
CPC分类号： B01D61/147 , A61K35/16 , A61M1/3486 , B01D63/02
摘要： A method for carrying out separation of plasma from whole blood, in which whole blood is passed through a filtration membrane means of a material suitable for separating plasma from whole blood and having a pore size from 0.1 to 0.6 microns at positive pressure differential across the membrane in a range up to just below 50 mm Hg. This provides an increased flow as compared to the flow obtained with higher pressures.
摘要翻译： 一种用于从全血中分离血浆的方法，其中全血通过过滤膜，适合于从全血分离血浆并具有0.1至0.6微米的孔径的材料，在正压差下穿过膜 在高达50 mm Hg以下的范围内。 与通过较高压力获得的流量相比，这提供了增加的流量。
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9.发明授权Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid 失效在线过滤从生理液体中除去大分子的方法和装置
公开(公告)号：US4350156A
公开(公告)日：1982-09-21
申请号：US154581
申请日：1980-05-29
申请人： Paul S. Malchesky , Yukihiko Nose
发明人： Paul S. Malchesky , Yukihiko Nose
IPC分类号： C07K1/14 , A61K35/14 , A61K38/16 , A61K39/00 , A61M1/34 , B01D61/16 , B01D61/20 , B01D61/22 , B01D61/58 , C07K14/76 , A61M5/00
CPC分类号： A61M1/3472 , A61M1/3482
摘要： An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous. Suitable agent(s) may be added to the separated plasma to promote formation of macromolecules.
摘要翻译： 用于去除大分子大于70,000mol的在线过滤系统。 重量 从生理解决方案，如血液，治疗各种疾病状态。 对于血液，使用膜孔隙率为0.2至1.0微米的第一膜过滤器，将血浆（其含有大分子）从血液连续分离。 然后将分离的等离子体在生理温度状态或冷却状态下通过具有标称为0.01至0.2微米的膜孔隙率的第二膜过滤器连续过滤，其保留大分子。 在冷却状态下，与非冷却状态相比，大分子的分离更有效。 然后将经处理的血浆（去除的大分子）与来自第一等离子体过滤器的血流重新团聚并返回给患者。 血流和过滤过程通常是连续的。 可以将合适的试剂加入到分离的等离子体中以促进大分子的形成。
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公开(公告)号：US4127481A
公开(公告)日：1978-11-28
申请号：US867089
申请日：1978-01-05
申请人： Paul S. Malchesky , Yukihiko Nose
发明人： Paul S. Malchesky , Yukihiko Nose
IPC分类号： A61M1/22 , A61M1/36 , B01D61/24 , B01D61/30 , B01D61/32 , B01D63/02 , B01D63/04 , B01D13/00 , B01D31/00
CPC分类号： B01D63/026 , A61M1/3679
摘要： Extracorporeal and implantable blood interchange devices used in providing interchange function of predetermined components with a fluid, such as for instance the removal of undesirable components from the bloodstream of a human and, characterized by capillary tubing having a reactor or sorbent material, such as activated charcoal, disposed within the lumens thereof, with the tubing being semi-permeable and with blood, or other fluid, being perfused over the capillary tubing in close physical contact with the exterior surfaces thereof, for accomplishing interchange coaction between the sorbent in the tubing and the perfusing fluid. Such tubing is arranged in rectangular configuration, with tangential entry and exit of perfused fluid.
摘要翻译： 用于提供预定组分与流体的交换功能的体外和可植入的血液互换装置，例如从人的血液中除去不需要的组分，其特征在于具有反应器或吸附剂材料的活性炭 设置在其腔内，其中管道是半渗透的，并且具有血液或其它流体，在与其外表面紧密物理接触的毛细管上灌注，以实现管道中的吸附剂和管道之间的交换配位 灌注液 这种管子被布置成矩形构型，并且灌注流体切向进入和离开。
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