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    Atherosclerosis genes and related reagents and methods of use thereof
    1.
    发明申请
    Atherosclerosis genes and related reagents and methods of use thereof 审中-公开
    动脉粥样硬化基因及相关试剂及其使用方法

    公开(公告)号：US20070253901A1

    公开(公告)日：2007-11-01

    申请号：US11412437

    申请日：2006-04-27

    申请人： David Deng ,  Anya Tsalenko ,  Amir Ben-Dor ,  Zohar Yakhini ,  Thomas Quertermous ,  Euan Ashley ,  Eugene Yang ,  Raymond Tabibiazar ,  Philip Tsao

    发明人： David Deng ,  Anya Tsalenko ,  Amir Ben-Dor ,  Zohar Yakhini ,  Thomas Quertermous ,  Euan Ashley ,  Eugene Yang ,  Raymond Tabibiazar ,  Philip Tsao

    IPC分类号： A61K51/00 ,  A61K49/10 ,  C07K16/46 ,  C07K14/54

    CPC分类号： G01N33/6893 ,  G01N2800/323

    摘要： The invention provides genes (DEA genes) that are differentially expressed in atherosclerotic lesions and polypeptides encoded by these genes. The invention provides compositions comprising a targeting agent conjugated to a functional moiety, wherein the targeting agent selectively binds to a polypeptide encoded by one a DEA gene. The functional moiety can be an imaging agent, therapeutic agent, etc. The invention further provides methods for providing diagnostic or prognostic information related to atherosclerosis involving detecting expression or activity of an expression product of one or more of the DEA genes. The invention further provides therapeutic methods comprising administering to a subject a composition comprising a targeting agent conjugated to a functional moiety that binds selectively binds to a polypeptide encoded by a DEA gene.

    摘要翻译： 本发明提供在动脉粥样硬化病变和由这些基因编码的多肽中差异表达的基因（DEA基因）。 本发明提供了包含与功能部分缀合的靶向剂的组合物，其中所述靶向剂选择性地结合由DEA基因之一编码的多肽。 功能部分可以是显像剂，治疗剂等。本发明还提供了提供涉及检测一种或多种DEA基因的表达产物的表达或活性的动脉粥样硬化相关的诊断或预后信息的方法。 本发明进一步提供治疗方法，包括向受试者施用包含与功能性部分缀合的靶向试剂的组合物，其结合选择性结合由DEA基因编码的多肽。

    Method and system for analysis of gene-expression data
    2.
    发明申请
    Method and system for analysis of gene-expression data 审中-公开
    用于分析基因表达数据的方法和系统

    公开(公告)号：US20060190190A1

    公开(公告)日：2006-08-24

    申请号：US11048970

    申请日：2005-02-02

    申请人： Zohar Yakhini ,  Amir Ben-Dor ,  Anya Tsalenko ,  David Deng

    发明人： Zohar Yakhini ,  Amir Ben-Dor ,  Anya Tsalenko ,  David Deng

    IPC分类号： G06F19/00

    CPC分类号： G16B25/00

    摘要： In various embodiments of the present invention, initial gene-expression data is initially partitioned into classes by patient, subject, or other identifier of a source of samples, expression-level-differences are computed for each gene with respect to each initial partition, and a rank consistency score or fold-change consistency score is computed for each gene from the expression-level difference metrics computed for each initial partition. In other words, rather than partitioning gene-expression-level data directly into two or more classes relative to an event of interest, the gene-expression-level data is first partitioned according to sample source, and then each sample-source partition is partitioned into two or more classes relative to an event of interest. Levels of significance, or p-values, can be straightforwardly computed for both rank consistency scores and fold-change consistency scores.

    摘要翻译： 在本发明的各种实施方案中，初始基因表达数据最初按照样品来源的患者，受试者或其他标识符分类，根据每个初始分区计算每个基因的表达水平差异， 根据为每个初始分区计算的表达级差异度量，为每个基因计算排序一致性分数或倍数变化一致性分数。 换句话说，不是将基因表达级数据直接分为两个或更多相关于感兴趣事件的类别，因此首先根据样本源分割基因表达级数据，然后将每个样本源分区分区 相对于感兴趣的事件进入两个或更多个类。 对于等级一致性分数和折叠一致性分数，可以直接计算重要程度或p值。

    Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures
    3.
    发明申请
    Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures 审中-公开
    使用基因表达特征确定混合细胞群体的细胞类型组成的系统和方法

    公开(公告)号：US20050048463A1

    公开(公告)日：2005-03-03

    申请号：US10841164

    申请日：2004-05-07

    申请人： David Deng ,  Anya Tsalenko ,  Zohar Yakhini ,  Laurakay Bruhn ,  Amir Ben-Dor

    发明人： David Deng ,  Anya Tsalenko ,  Zohar Yakhini ,  Laurakay Bruhn ,  Amir Ben-Dor

    IPC分类号： C12Q1/68 ,  C12Q1/70 ,  G06F19/00

    CPC分类号： G16B40/00 ,  G16B25/00

    摘要： The present invention provides systems and methods for determining the cell type composition of a mixed cell population. The invention provides systems and methods for identifying and defining pure cell type specific signatures. These pure cell type specific signatures may be used to determine the cell type composition of a mixed cell population. The systems and methods of the invention may be used for a variety of research and clinical purposes. For example, they may be used to detect the presence or absence of cells of particular types, and to determine whether variations in gene expression, e.g., between different samples, represent true changes in gene expression or differences in cell type composition of the samples.

    摘要翻译： 本发明提供了用于确定混合细胞群体的细胞类型组成的系统和方法。 本发明提供用于识别和定义纯细胞类型特异性特征的系统和方法。 这些纯细胞类型特异性标记可用于确定混合细胞群体的细胞类型组成。 本发明的系统和方法可用于各种研究和临床目的。 例如，它们可以用于检测特定类型的细胞的存在或不存在，并且确定基因表达的变化，例如不同样品之间的变化是否代表基因表达的真实变化或样品的细胞类型组成的差异。

    System and methods for the management and treatment of vascular graft disease
    5.
    发明申请
    System and methods for the management and treatment of vascular graft disease 审中-公开
    血管移植疾病的治疗和治疗的系统和方法

    公开(公告)号：US20060003338A1

    公开(公告)日：2006-01-05

    申请号：US10882014

    申请日：2004-06-30

    申请人： David Deng ,  Anya Tsalenko

    发明人： David Deng ,  Anya Tsalenko

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/6893 ,  G01N2800/245

    摘要： Various embodiments of the present invention are directed to a system and methods for minimizing risk factors that contribute to the development of vascular graft disease and vascular graft failure. In one embodiment, a microarray-based gene expression analysis may be employed to select pre-implanted vessel candidates suitable as grafts in various vascular transplantation procedures. By using a microarray that includes a set of probe sequences that statistically correlate with vascular graft disease, mRNA expression levels of vascular-graft-disease-related genes within vessel-graft candidates can be determined to produce an expression profile for each vessel tested. Such molecular profile of genes related to various forms of vascular graft disease enables clinicians to select a vessel graft having the lowest probability of developing vascular graft diseases, and having the highest probability of maintaining adequate patency rate. Various types of arteries and veins may be discriminated from one another based on their respective gene expression profiles.

    摘要翻译： 本发明的各种实施方案涉及用于最小化有助于血管移植物疾病和血管移植物衰竭发展的危险因素的系统和方法。 在一个实施方案中，基于微阵列的基因表达分析可用于选择适合于各种血管移植手术中的移植物的预先植入的血管候选物。 通过使用包括与血管移植疾病统计学相关的一组探针序列的微阵列，可以确定血管移植物候选物中的血管移植物疾病相关基因的mRNA表达水平以产生每个测试血管的表达谱。 与各种形式的血管移植疾病相关的基因的这种分子谱可使临床医生选择血管移植疾病发展概率最低的血管移植物，并具有维持足够通畅率的最高概率。 基于各自的基因表达谱，可以区分各种类型的动脉和静脉。

    DUAL FUEL HEATING ASSEMBLY WITH RESET SWITCH
    8.
    发明申请
    DUAL FUEL HEATING ASSEMBLY WITH RESET SWITCH 审中-公开
    双燃料加热组件与复位开关

    公开(公告)号：US20150338099A1

    公开(公告)日：2015-11-26

    申请号：US14713947

    申请日：2015-05-15

    申请人： David Deng

    发明人： David Deng

    IPC分类号： F23N1/00 ,  F23D23/00 ,  F24H3/00

    CPC分类号： F23N1/007 ,  F23D23/00 ,  F23D2204/00 ,  F24D2200/04 ,  F24H3/006 ,  F24H9/0094 ,  F24H9/2085

    摘要： A heating assembly can include a locking valve with a reset switch which can include certain pressure sensitive features. These features can be configured to change from a first position to a second position based on a pressure of a fuel. The valve can be used with either a first fuel or a second fuel different from the first. The valve can become locked or be held in either the first or the second position. For example, a set fuel pressure can cause the valve to move to a closed position and the valve can become locked or held in that position. If the pressure decreases, the valve can remain in the locked position. Actuation of the reset switch can allow the valve to move to a new position, such as an open position. The locking valve can be linked to additional valves to lock them in position as well.

    摘要翻译： 加热组件可以包括具有复位开关的锁定阀，该复位开关可以包括某些压力敏感特征。 这些特征可以被配置为基于燃料的压力从第一位置改变到第二位置。 阀可以与第一燃料或不同于第一燃料的第二燃料一起使用。 阀可以被锁定或保持在第一或第二位置。 例如，设定的燃料压力可以导致阀移动到关闭位置，并且阀可以被锁定或保持在该位置。 如果压力降低，阀门可以保持在锁定位置。 复位开关的启动可允许阀移动到新位置，例如打开位置。 锁定阀可以连接到附加阀门，以将其锁定在适当位置。

    Dual fuel heater with selector valve
    9.
    发明授权
    Dual fuel heater with selector valve 有权
    双燃料加热器带选择阀

    公开(公告)号：US09175848B2

    公开(公告)日：2015-11-03

    申请号：US13791772

    申请日：2013-03-08

    申请人： David Deng

    发明人： David Deng

    IPC分类号： F23Q9/08 ,  F23C1/08 ,  F23D23/00 ,  F23N1/00

    CPC分类号： F23C1/08 ,  F23D23/00 ,  F23D2204/00 ,  F23N1/007 ,  F23N2035/24

    摘要： A heater assembly can be used with a gas appliance. The gas appliance can be a dual fuel appliance for use with one of a first fuel type or a second fuel type different than the first. The heater assembly can include at least one pressure regulator, a housing, and an actuation member. The housing has a first fuel hook-up for connecting the first fuel type to the heater assembly, and a second fuel hook-up for connecting the second fuel type to the heater assembly. The actuation member can control a flow through the heater assembly based on whether the first or the second fuel hook-up is used.

    摘要翻译： 加热器组件可以与燃气器具一起使用。 燃气器具可以是与不同于第一燃料类型的第一燃料类型或第二燃料类型中的一种一起使用的双燃料器具。 加热器组件可以包括至少一个压力调节器，壳体和致动构件。 壳体具有用于将第一燃料类型连接到加热器组件的第一燃料连接器和用于将第二燃料类型连接到加热器组件的第二燃料连接器。 致动构件可以基于是否使用第一或第二燃料连接来控制通过加热器组件的流动。

    Dual fuel heater with selector valve
    10.
    发明授权
    Dual fuel heater with selector valve 有权

    公开(公告)号：US09170016B2

    公开(公告)日：2015-10-27

    申请号：US13791530

    申请日：2013-03-08

    申请人： David Deng

    发明人： David Deng

    IPC分类号： F23C1/08 ,  F23N1/00

    CPC分类号： F23C1/08 ,  F23N1/00 ,  F23N1/007 ,  F23N2035/14 ,  F23N2035/18 ,  F23N2035/24 ,  F23N2037/08 ,  F24C1/02

    摘要： A heater assembly can be used with a gas appliance. The gas appliance can be a dual fuel appliance for use with one of a first fuel type or a second fuel type different than the first. The heater assembly can include at least one pressure regulator, a housing, and an actuation member. The housing has a first fuel hook-up for connecting the first fuel type to the heater assembly, and a second fuel hook-up for connecting the second fuel type to the heater assembly. The actuation member can control a flow through the heater assembly based on whether the first or the second fuel hook-up is used.