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公开(公告)号：US20230390305A1
公开(公告)日：2023-12-07
申请号：US18355684
申请日：2023-07-20
Applicant: MARINUS PHARMACEUTICALS, INC.
Inventor： David CZEKAI , Vinod TULIANI , Michael SAPORITO
Abstract: This disclosure relates to a solid pharmaceutical formulation comprising an amorphous neurosteroid dispersed in a polymer matrix that is suitable for oral administration. The disclosure also relates to methods for effectively treating an epileptic disorder, central nervous system disorder, or a neurological disorder. The methods disclosed herein comprise orally administering to a subject in need thereof a therapeutically effective amount of the solid pharmaceutical formulation disclosed herein comprising an amorphous neurosteroid, preferably ganaxolone dispersed in a polymer matrix.
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公开(公告)号：US20230364109A1
公开(公告)日：2023-11-16
申请号：US18321374
申请日：2023-05-22
Applicant: MARINUS PHARMACEUTICALS, INC.
Inventor： Henrikas VAITKEVICIUS , Maciej GASIOR , Joseph HULIHAN
IPC: A61K31/573 , A61K9/00 , A61P25/08
CPC classification number: A61K31/573 , A61K9/0019 , A61P25/08
Abstract: This invention relates to methods for treating super refractory status epilepticus by rapidly weaning the subject in need thereof off an anesthetic agent prior to initiation of administering to the subject in need thereof of ganaxolone at a high infusion dose. The method provides SE suppression and continued suppression of SE.
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公开(公告)号：US20220265680A1
公开(公告)日：2022-08-25
申请号：US17729427
申请日：2022-04-26
Applicant: MARINUS PHARMACEUTICALS, INC.
Inventor： David CZEKAI , Maciej GASIOR , Lorianne MASUOKA , Julia TSAI , Joseph HULIHAN , Alex AIMETTI
IPC: A61K31/573 , A61K9/00 , A61P25/08
Abstract: This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
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公开(公告)号：US20220211723A1
公开(公告)日：2022-07-07
申请号：US17683624
申请日：2022-03-01
Applicant: Marinus Pharmaceuticals, Inc.
Inventor： Alex AIMETTI , Joseph HULIHAN , Scott BRAUNSTEIN
Abstract: The disclosure to methods for treating tuberous sclerosis complex or tuberous sclerosis complex-related epilepsy, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutically acceptable pregnenolone neurosteroid, such as ganaxolone, to reduce one or more symptoms of tuberous sclerosis complex or tuberous sclerosis complex-related epilepsy.
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公开(公告)号：US11071740B2
公开(公告)日：2021-07-27
申请号：US16149970
申请日：2018-10-02
Applicant: Marinus Pharmaceuticals, Inc.
Inventor： Kenneth Shaw , Mingbao Zhang
IPC: A01N43/00 , A61K31/33 , A61K31/573 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50 , A61K31/57 , A61K9/00 , A61K47/02 , A61K47/26
Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
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Patent Agency Ranking
公开(公告)号：US20200179403A1
公开(公告)日：2020-06-11
申请号：US16705541
申请日：2019-12-06
Applicant: Marinus Pharmaceuticals, Inc.
Inventor： Alex Aimetti , Christopher Cashman , Lorianne Masuoka , Jaakko Lappalainen
Abstract: Uses of ganaxolone in prophylaxis and treatment of postpartum depression are described. A dose of ganaxolone is administered to a female suffering from postpartum depression or at risk of developing postpartum depression in an amount and at a rate sufficient to alleviate at least one symptom of postpartum depression in the female.
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公开(公告)号：US20190117673A1
公开(公告)日：2019-04-25
申请号：US16149958
申请日：2018-10-02
Applicant: Marinus Pharmaceuticals, Inc.
Inventor： Kenneth Shaw , Mingbao Zhang
IPC: A61K31/573 , A61K31/57 , A61K9/10 , A61K47/02 , A61K9/00 , A61K47/26 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/48 , A61K9/28 , A61K9/20
Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
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公开(公告)号：US09452176B2
公开(公告)日：2016-09-27
申请号：US14709062
申请日：2015-05-11
Applicant: Marinus Pharmaceuticals
Inventor： Kenneth Shaw , Mingbao Zhang
IPC: A01N43/00 , A61K31/33 , A61K31/57 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50
CPC classification number: A61K31/573 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1676 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4891 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/57 , A61K47/02 , A61K47/26 , Y10S977/773 , Y10S977/775 , Y10S977/906 , Y10S977/915
Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
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9.发明授权公开(公告)号：US09029355B2
公开(公告)日：2015-05-12
申请号：US14087903
申请日：2013-11-22
Applicant: Marinus Pharmaceuticals
Inventor： Kenneth Shaw , Mingbao Zhang
IPC: A01N43/00 , A61K31/33 , A61K31/57 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50
CPC classification number: A61K31/573 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1676 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4891 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/57 , A61K47/02 , A61K47/26 , Y10S977/773 , Y10S977/775 , Y10S977/906 , Y10S977/915
Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
Abstract translation: 在某些实施方案中，本发明涉及包含稳定的颗粒的组合物，所述稳定颗粒包含加纳西酮，其中颗粒的体积加权中位数直径（D50）为约50nm至约500nm。
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10.发明授权公开(公告)号：US08362286B2
公开(公告)日：2013-01-29
申请号：US12854226
申请日：2010-08-11
Applicant: Kenneth Shaw , Alan Hutchison
Inventor： Kenneth Shaw , Alan Hutchison
IPC: C07J7/00
CPC classification number: A61K31/57 , A61K31/575 , C07J7/002 , C07J7/0045 , C07J9/00
Abstract: Applicants have discovered a method for the stereoselective and regioselective synthesis of 3α-hydroxy, 3β-methyl-5α-pregnan-20-one (ganaxolone) comprising reacting 5α-pregnane-3,20-dione; with an organometallic methylating agent in an inert solvent to provide a compound of the formula
Abstract translation: 申请人已经发现了一种立体选择性和区域选择性合成3α-羟基，3'-溴-α-甲基-5α-孕烷-20-酮（ganaxolone）的方法，包括使5α-孕烷-3,20-二酮反应; 与有机金属甲基化剂在惰性溶剂中反应，得到下式的化合物
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