公开(公告)号：US4031240A

公开(公告)日：1977-06-21

申请号：US612775

申请日：1975-09-12

Applicant: Antonio Esteve-Subirana

Inventor： Antonio Esteve-Subirana

IPC: C07C69/76 ,  C07C309/42

CPC classification number: C07C309/00

Abstract: Mono- and diesters of 2,5-dihydroxy benzene sulfonic acid are represented by the following formula: ##STR1## wherein each R residue is hydrogen or the residue of p-chlorophenoxy isobutyric acid having the formula: ##STR2## with the proviso that both Rs are not hydrogen simultaneously, and B is hydrogen or the equivalent of an inorganic or organic cation, these compounds are remarkable for their hypocholesterolemic, hypotriglycidemic and hypolipidemic activity.

Abstract translation: 2,5-二羟基苯磺酸的单酯和二酯由下式表示：其中每个R残基是氢或具有下式的对氯苯氧基异丁酸的残基：，条件是两者 Rs同时不是氢，B是氢或无机或有机阳离子的当量，这些化合物对于低胆固醇血症，低血尿和降血脂活性而言是显着的。

公开(公告)号：US4005220A

公开(公告)日：1977-01-25

申请号：US564735

申请日：1975-04-03

Applicant: Antonio Esteve-Subirana

Inventor： Antonio Esteve-Subirana

IPC: A61K31/185 ,  A61K31/205

CPC classification number: C07C309/00

Abstract: Novel salts of substituted hydroquinone sulfonic acid having the general formula: ##STR1## in which R denotes ammonium or a cation of an organic base such as alkylamines, alkanolamines, arylamines, alkylarylamines, aralkylamines and cyclamines, or a cation of an alkali or alkaline earth metal such as lithium, sodium, potassium, magnesium or calcium. The structure of course depends on the valency of R. In every case, R' denotes a linear or branched alkyl group with 1 to 6 carbon atoms. These salts are used as haemostatic agents and protective agents against capillary fragility.

Abstract translation: 具有以下通式的取代氢醌磺酸的新型盐：其中R表示铵或有机碱的阳离子如烷基胺，链烷醇胺，芳基胺，烷基芳基胺，芳烷基胺和环胺，或碱金属或碱土金属的阳离子 金属如锂，钠，钾，镁或钙。 结构当然取决于R的化合价。在任何情况下，R'表示具有1至6个碳原子的直链或支链烷基。 这些盐用作止血剂和抗毛细血管脆性的保护剂。

公开(公告)号：US20210246172A1

公开(公告)日：2021-08-12

申请号：US17244042

申请日：2021-04-29

Applicant: LABORATORIOS DEL DR. ESTEVE S.A. ,  FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA - CAIXA

Inventor： Christian BRANDER ,  Beatriz Mothe PUJADAS ,  Anuska LLANO

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  C12N7/00

Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.

公开(公告)号：US10246465B2

公开(公告)日：2019-04-02

申请号：US15315486

申请日：2015-06-02

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Marina Virgili-Bernado ,  Monica Alonso-Xalma ,  Carlos Alegret-Molina ,  Carmen Almansa-Rosales ,  Monica Garcia Lopez

IPC: C07D498/10

Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US10189828B2

公开(公告)日：2019-01-29

申请号：US15531571

申请日：2015-12-15

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Carmen Almansa-Rosales ,  Monica Garcia-Lopez ,  Lourdes Garriga-Sanahuja ,  Ana Virginia Llorente-Fernandez

IPC: C07D231/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D417/12 ,  A61K31/4523 ,  A61K31/496 ,  C07D417/14 ,  C07D401/06

Abstract: The present invention relates to 1-methylpyrazole-piperazine compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US10183918B2

公开(公告)日：2019-01-22

申请号：US15769502

申请日：2016-10-21

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Carmen Almansa-Rosales ,  Carlos Alegret-Molina

IPC: C07D265/34

Abstract: The present invention relates to oxa-azaspiro compounds having pharmacological activity towards the sigma (σ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US20190010128A1

公开(公告)日：2019-01-10

申请号：US15886145

申请日：2018-02-01

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Helmut Heinrich Buschmann ,  Jose Miguel Vela-Hernandez ,  Daniel Zamanillo-Castanedo

IPC: C07D231/22 ,  A61K31/5377 ,  A61K31/485 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K45/06 ,  A61K31/4152 ,  A61K31/4155

Abstract: The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.

公开(公告)号：US20180305343A1

公开(公告)日：2018-10-25

申请号：US15769520

申请日：2016-10-21

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Marina VIRGILI-BERNADO ,  Carlos ALEGRET-MOLINA

IPC: C07D413/04 ,  A61P29/00

CPC classification number: C07D413/04 ,  A61P29/00

Abstract: The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (σ) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US09931346B2

公开(公告)日：2018-04-03

申请号：US15104384

申请日：2014-12-16

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Daniel Zamanillo-Castanedo ,  Enrique Portillo-Salido

IPC: A61K31/5377 ,  A61K45/06 ,  A61K31/137 ,  A61K31/381

CPC classification number: A61K31/5377 ,  A61K31/137 ,  A61K31/381 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention refers to a synergistic combination comprising a Sigma ligand of general formula (I), and a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), a medicament comprising said active substance combination, and the use of said active substance combination for the manufacture of a medicament, particularly for the prophylaxis and/or treatment of pain.

公开(公告)号：US09879015B2

公开(公告)日：2018-01-30

申请号：US14785961

申请日：2014-04-22

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Ramón Merce-Vidal ,  José-Luis Díaz-Fernández

IPC: C07D487/04 ,  A61K31/4985

CPC classification number: C07D487/04

Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.