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    METHOD FOR PRODUCING RENAL INTERSTITIAL CELL
    91.
    发明申请
    METHOD FOR PRODUCING RENAL INTERSTITIAL CELL 有权

    公开(公告)号：US20220313733A1

    公开(公告)日：2022-10-06

    申请号：US17618080

    申请日：2020-06-10

    Applicant: Kyoto University ,  Takeda Pharmaceutical Company Limited

    Inventor： Makoto IKEYA ,  Daisuke KAMIYA

    IPC: A61K35/12 ,  C12N5/0797 ,  C12N5/071

    Abstract: A method for producing renal stromal cells, comprising a step (3) of culturing renal stromal precursors in a medium comprising a platelet derived growth factor receptor agonist to obtain renal stromal cells is provided as a technique for supplying renal stromal cells. This production method can further comprise a step (2) of inducing renal stromal precursors from neural crest cells, and a step (1) of culturing pluripotent stem cells in a medium comprising a GSK3β inhibitor, a TGFβ inhibitor, and retinoic acid and/or a derivative thereof to induce neural crest cells.

    TREATMENT OF GASTROPARESIS WITH TRIAZASPIRO[4.5]DECANONE
    93.
    发明申请
    TREATMENT OF GASTROPARESIS WITH TRIAZASPIRO[4.5]DECANONE 有权

    公开(公告)号：US20220288042A1

    公开(公告)日：2022-09-15

    申请号：US17829439

    申请日：2022-06-01

    Applicant: Takeda Pharmaceutical Company Limited

    Inventor： Emil Chuang

    IPC: A61K31/438 ,  A61P1/14

    Abstract: Provided herein is a method of treating or alleviating one or more symptoms of a disorder, disease, or condition mediated by a dopamine D2 or D3 receptor with 3-((1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid or a pharmaceutically acceptable salt thereof. Also provided herein is a method of increasing the scrum prolactin level with 3-((1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid or a pharmaceutically acceptable salt thereof.

    TRANSFECTION METHOD
    94.
    发明申请
    TRANSFECTION METHOD 有权

    公开(公告)号：US20220251576A1

    公开(公告)日：2022-08-11

    申请号：US17622580

    申请日：2020-06-25

    Applicant: Takeda Pharmaceutical Company Limited

    Inventor： Naoyuki MURATA ,  Sayan CHUANOI ,  Shigeo YANAI

    IPC: C12N15/64 ,  C07K14/725 ,  A61P37/00 ,  A61K9/00 ,  A61K9/51 ,  A61K9/08 ,  A61K47/26

    Abstract: A novel means for safely and efficiently introducing a target substance such as nucleic acid, protein, or the like into immune cells such as T cell and the like is provided by the present invention. Thus, a system for delivering a target substance into an immune cell, including ultrafine bubble water or ultrafine bubble aqueous solution containing ultrafine bubbles with an average diameter of not more than 200 nm and not containing phospholipid, and an ultrasound generator in combination; a method for increasing the delivery of a nucleic acid or a protein into an immune cell by using the ultrafine bubble water, etc. and ultrasound; and the like are provided.

    COMPOSITIONS OF THIENOPYRIMIDINE DERIVATIVES
    97.
    发明申请
    COMPOSITIONS OF THIENOPYRIMIDINE DERIVATIVES 有权

    公开(公告)号：US20220204525A1

    公开(公告)日：2022-06-30

    申请号：US17694635

    申请日：2022-03-14

    Applicant: Takeda Pharmaceutical Company Limited

    Inventor： Koichiro FUKUOKA ,  Kazuhiro MIWA ,  Tsuyoshi SASAKI ,  Fumiya KOMURA

    IPC: C07D495/04 ,  C07D333/38 ,  C07D409/12

    Abstract: The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrirnidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

    TREATMENT OF CNS CONDITIONS
    99.
    发明申请
    TREATMENT OF CNS CONDITIONS 有权

    公开(公告)号：US20220168294A1

    公开(公告)日：2022-06-02

    申请号：US17673072

    申请日：2022-02-16

    Applicant: Takeda Pharmaceutical Company Limited

    Inventor： Toshiya Nishi ,  Shinichi KONDO

    IPC: A61K31/4545 ,  A61P25/08

    Abstract: Aspects of the present invention relate to a method of treating an epileptic encephalopathy in a mammal in need thereof, comprising administering a composition comprising an effective amount of (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a pharmaceutically acceptable salt thereof to the mammal.

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