公开(公告)号：US11584725B2

公开(公告)日：2023-02-21

申请号：US16674651

申请日：2019-11-05

申请人： Augusta University Research Institute, Inc.

发明人： Siva Panda

IPC分类号： C07D241/24 ,  C07D401/12 ,  C07D413/12 ,  A61P31/06 ,  C07D401/14 ,  A61K9/00

摘要： Pyrazinamide (PZA) conjugates and hybrids are provided herein. The PZA conjugates are useful for treating bacterial infections. In one embodiment, the PZA conjugates are useful for treating tuberculosis.

公开(公告)号：US20230051690A1

公开(公告)日：2023-02-16

申请号：US17933276

申请日：2022-09-19

申请人： Augusta University Research Institute, Inc.

发明人： Ahmed Chadli

IPC分类号： A61K38/12 ,  A61P35/00

摘要： It has been discovered that the cyclic peptide EnnA inactivates the Hsp90 chaperone pathway, but without activating an extensive heat shock response and overexpression of anti-apoptotic proteins. Mechanistically distinct, EnnA inhibits Hsp90 and destabilize PDL-1 and IDO, two major immune checkpoints mediating tumor-induced immune suppression. The provided herein show that EnnA profoundly modulates the cytokine signature of cancer cells and promotes a cytokine profile that favors an immune attack on tumor cells. This translates into highly efficacious anti-tumor activity in vivo, which, when combined with a single dose of chemotherapy, completely reduced the tumor burden in experimental animals and instilled highly efficient immune memory against the primary tumor.

公开(公告)号：US20230000818A1

公开(公告)日：2023-01-05

申请号：US17810484

申请日：2022-07-01

申请人： AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.

发明人： Babak BABAN ,  Krishnan DHANDAPANI ,  Jack C. YU

IPC分类号： A61K31/352 ,  A61K9/00 ,  A61P31/14

摘要： Compositions and methods for treating or reducing symptoms of acute respiratory distress syndrome (ARDS) generally and COVID-19 infection in particular are provided herein. An exemplary method includes administering to the subject an effective amount of cannabichromene to reduce acute respiratory distress syndrome caused by ARDS generally and COVID-19 infection in particular.

公开(公告)号：US11524091B2

公开(公告)日：2022-12-13

申请号：US16541252

申请日：2019-08-15

申请人： Augusta University Research Institute, Inc.

发明人： Mahmood Mozaffari ,  Babak Baban ,  Rafik Abdelsayed

IPC分类号： A61L26/00 ,  A61K38/17 ,  C07K14/47

摘要： Glucocorticoid-induced leucine zipper protein (GILZ) peptide compositions and their methods of use in wound healing are disclosed herein. An exemplary GILZ peptide composition includes a GILZ fusion protein. The GILZ peptide compositions can be administered topically to wounds, for example in the form of a cream, ointment, or lotion. The GILZ peptide compositions can be used to treat acute wounds, induce wound healing in chronic wounds, and reduce scar formation.

公开(公告)号：USD970000S1

公开(公告)日：2022-11-15

申请号：US29773981

申请日：2021-03-12

申请人： Augusta University Research Institute, Inc.

设计人： Jeffrey James

公开(公告)号：US11446352B2

公开(公告)日：2022-09-20

申请号：US16180203

申请日：2018-11-05

申请人： Augusta University Research Institute, Inc.

发明人： Ahmed Chadli

IPC分类号： A61K38/12 ,  A61P35/00 ,  A61K31/664

摘要： It has been discovered that the cyclic peptide EnnA inactivates the Hsp90 chaperone pathway, but without activating an extensive heat shock response and overexpression of anti-apoptotic proteins. Mechanistically distinct, EnnA inhibits Hsp90 and destabilize PDL-1 and IDO, two major immune checkpoints mediating tumor-induced immune suppression. The provided herein show that EnnA profoundly modulates the cytokine signature of cancer cells and promotes a cytokine profile that favors an immune attack on tumor cells. This translates into highly efficacious anti-tumor activity in vivo, which, when combined with a single dose of chemotherapy, completely reduced the tumor burden in experimental animals and instilled highly efficient immune memory against the primary tumor.

公开(公告)号：US20220266014A1

公开(公告)日：2022-08-25

申请号：US17680034

申请日：2022-02-24

申请人： Boston Scientific Neuromodulation Corporation ,  Augusta University Research Institute, Inc.

发明人： Michael A. Moffitt ,  David Blake

IPC分类号： A61N1/36 ,  A61N1/05

摘要： A system for stimulation of a nucleus basalis of Meynert (NBM) of a patient includes an implantable electrical stimulation lead including electrodes and configured for implantation of at least one of the electrodes adjacent to or within the NBM of the patient; and an implantable pulse generator coupleable to the implantable electrical stimulation lead and configured for delivering electrical stimulation to the NBM through at least one of the electrodes of the implantable electrical stimulation lead, the implantable pulse generator including at least one processor configured to, upon user request, during an initial stimulation period, which is at least 1 month in duration and has a start and an end, increase over time at least one of a duration or an amplitude of the electrical stimulation from an initial value at the start of the initial stimulation period to a final value at the end of the initial stimulation period.

公开(公告)号：US11357225B2

公开(公告)日：2022-06-14

申请号：US16149379

申请日：2018-10-02

申请人： Augusta University Research Institute, Inc.

发明人： Ali Eroglu

IPC分类号： A01N1/02 ,  C12N5/075 ,  C12N5/071

摘要： Methods are disclosed for viable preservation of biomaterials including both prokaryotic and eukaryotic cells/materials such as human cells and tissues at subzero and suprazero temperatures. One embodiment provides a method wherein initial desiccation and subsequent cooling of the biological samples is below their glass transition temperature (Tg) to achieve a stable glassy state without exposing the biomaterials to excessive osmotic/chemical stresses for long periods of time. Another embodiment provides a method that includes combining the initial desiccation with subsequent freeze-drying to achieve a glassy state of biomaterials. Another embodiment provides a desiccation medium with low salt, high osmolyte/glass former content and desiccation of biomaterials in a spherical droplet to avoid the edge effect.

公开(公告)号：US11351202B2

公开(公告)日：2022-06-07

申请号：US15849181

申请日：2017-12-20

申请人： ATHERSYS, INC. ,  AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.

发明人： Robert Mays ,  Robert J. Deans ,  David C. Hess ,  James E. Carroll ,  Cesar V. Borlongan

IPC分类号： A61K35/28 ,  A61K35/50 ,  A61K35/545 ,  A61K38/13 ,  A61K45/06 ,  C12N5/074 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/485 ,  A61K31/52 ,  A61K31/661 ,  A61K35/12 ,  A61K35/30 ,  A61K35/407 ,  A61K35/44 ,  A61K35/48 ,  A61K35/51

摘要： The invention relates to the treatment of various injuries, disorders, dysfunctions, diseases, and the like of the brain with MAPCs, particularly in some aspects, to the treatment of the same resulting from hypoxia, including that caused by systemic hypoxia and that caused by insufficient blood supply. In some further particulars the invention relates, for example, to the treatment of hypoxic ischemic brain injury with MAPCs, in children for example, and to the treatment of cortical infarcts and stroke with MAPCs in adults, for example.

公开(公告)号：US20220113312A1

公开(公告)日：2022-04-14

申请号：US17499444

申请日：2021-10-12

申请人： Augusta University Research Institute, Inc.

发明人： Jin-Xiong SHE ,  Sharad Purohit

IPC分类号： G01N33/574 ,  G16B40/00 ,  G16B5/20

摘要： Disclosed herein are methods of treating and making prognostic prediction of, monitoring of therapeutic outcome for treatment of cervical carcinoma in a patient in need thereof by quantifying gene expression in a sample, wherein the genes include 10 high risk genes; calculating the subject's survival risk score by determining the protein expression levels and their relationships using machine learning (ML) and artificial intelligence. The survival risk category of a patient is determined by the consensus or plurality voting of a large number of ML models that individually have excellent predictive potential, thus providing a very robust prognostic biomarker for cervical carcinoma.