Adenosine derivatives
    92.
    发明授权
    Adenosine derivatives 失效
    腺苷衍生物

    公开(公告)号:US4464361A

    公开(公告)日:1984-08-07

    申请号:US368416

    申请日:1982-04-14

    CPC分类号: C07H19/16

    摘要: Adenosine derivatives of the general formula: ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which R.sup.5 and R.sup.6 are each hydrogen, alkoxy or arylthio and R.sup.7 is hydrogen or halogen, or a group of the formula: ##STR3## and R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or alkanoyl, and pharmaceutically acceptable salt thereof.These derivatives and salts thereof are useful as antihypertensives, bradycardiacs, etc. The method of production thereof and pharmaceutical compositions based on those adenosine derivatives or salts are also described.

    摘要翻译: 其中R 1是下式的基团:其中R 5和R 6各自是氢,烷氧基或芳硫基,R 7是氢或卤素,或下式的基团:IMAMA 且R 2,R 3和R 4各自为氢或烷酰基,及其药学上可接受的盐。 这些衍生物和盐可​​用作抗高血压药,心动过缓等。其制备方法和基于这些腺苷衍生物或盐的药物组合物也被描述。

    Antiallergic methods
    93.
    发明授权
    Antiallergic methods 失效
    抗过敏方法

    公开(公告)号:US4185119A

    公开(公告)日:1980-01-22

    申请号:US910511

    申请日:1978-05-30

    CPC分类号: A61K31/47

    摘要: Compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or methyl, providing that when R.sub.1 is hydrogen, R.sub.2 is hydrogen, have been found to be useful in relieving allergic symptoms by inhibiting histamine-release from mast cells. They can be used in free form or in the form of pharmaceutically acceptable acid addition salts.

    摘要翻译: 通式:其中R 1和R 2各自为氢或甲基的化合物,条件是当R 1为氢时,R 2为氢,已被发现可用于通过抑制组胺释放肥大细胞来减轻过敏症状。 它们可以以游离形式或以药学上可接受的酸加成盐的形式使用。