公开(公告)号：US20110038900A1

公开(公告)日：2011-02-17

申请号：US12990110

申请日：2009-04-28

Applicant: Aravind Chakrapani ,  Manmohan Singh ,  Derek O'Hagan

Inventor： Aravind Chakrapani ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/00 ,  A61K9/00 ,  A61P37/00 ,  B82Y40/00 ,  B82Y5/00

CPC classification number: A61K39/095 ,  A61K2039/55555 ,  A61K2039/62 ,  C08J3/14 ,  C08J2300/16 ,  C08J2367/04

Abstract: In various aspects of the present invention, nanoparticle compositions are provided which comprise (a) nanoparticles comprising at least one biodegradable polymer and (b) at least one pharmaceutical associated with the nanoparticles. In other aspects of the present invention, methods of forming nanoparticles compositions are provided, which comprise contacting a first liquid that comprises one or more biodegradable polymers dissolved in a first solvent with a second liquid that comprises a second solvent which is miscible with the first solvent while being a non-solvent for the one or more biodegradable polymers, such that nanoparticles are formed.

Abstract translation: 在本发明的各个方面，提供纳米颗粒组合物，其包含（a）包含至少一种生物可降解聚合物的纳米颗粒和（b）至少一种与纳米颗粒相关的药物。 在本发明的其他方面，提供了形成纳米颗粒组合物的方法，其包括将包含溶解在第一溶剂中的一种或多种可生物降解的聚合物的第一液体与包含与第一溶剂混溶的第二溶剂的第二液体接触 同时作为一种或多种可生物降解的聚合物的非溶剂，使得形成纳米颗粒。

公开(公告)号：US20100285069A1

公开(公告)日：2010-11-11

申请号：US12734185

申请日：2008-10-17

Applicant: Mario Contorni ,  Jina Kazzaz ,  Derek O'Hagan ,  Manmohan Singh ,  Mildred Ugozzoli

Inventor： Mario Contorni ,  Jina Kazzaz ,  Derek O'Hagan ,  Manmohan Singh ,  Mildred Ugozzoli

IPC: A61K39/095 ,  A61P37/04

CPC classification number: A61K39/095 ,  A61K9/107 ,  A61K9/19 ,  A61K2039/55566

Abstract: A dual formulation for vaccines against Neisseria meningitidis serogroup B (‘Men-B’) comprises (i) an oil-in-water emulsion adjuvant and (ii) a Men-B immunogenic component in lyophilised form. The lyophilised Men-B antigens can be reconstituted into liquid adjuvanted form at the time of use ready for administration to a patient. This formulation has been found to give excellent result in terms of both stability and immunogenicity. The lyophilised component can also include one or more conjugated saccharides from N. meningitidis in serogroups A, C, W135 and/or Y.

Abstract translation: 针对脑膜炎奈瑟氏球菌血清群B（'Men-B'）的疫苗的双重配方包括（i）水包油乳剂佐剂和（ii）冻干形式的Men-B免疫原性组分。 冻干的Men-B抗原可以在使用时重建成液体佐剂形式，准备用于给予患者。 已经发现这种配方在稳定性和免疫原性方面都获得了优异的结果。 冻干组分还可以包含一种或多种血清群A，C，W135和/或Y中脑膜炎奈瑟氏球菌的共轭糖。

公开(公告)号：US20100000397A1

公开(公告)日：2010-01-07

申请号：US12541827

申请日：2009-08-14

Applicant: Dan W. Pratt ,  Manmohan Singh Chawla

Inventor： Dan W. Pratt ,  Manmohan Singh Chawla

IPC: E21B43/117

CPC classification number: E21B43/117 ,  F42B1/028 ,  F42D3/00

Abstract: A perforating system has a perforating module comprising a unitary body of explosive. The explosive is contained within a non-explosive casing, or liner, having formed indentations and a cover thereover. The indentations, which will transform into explosively formed penetrators (EFP's) upon detonation, have a perimeter shape that allows for improved packing density, e.g., a hexagonal perimeter, which results in relatively little “dead space” wherein no perforating penetrators are generated. In operation, the module provides a relatively dense shot pattern and substantially reduced amount of post-detonation debris that could clog the perforations and/or require remedial clean-up or repeat perforation.

Abstract translation: 射孔系统具有包括一体的爆炸物的穿孔模块。 爆炸物包含在不爆炸的外壳或内衬中，其上形成有凹痕和盖。 在爆炸时将变成爆炸形成的穿透器（EFP）的凹陷具有允许改进的填充密度（例如六边形周长）的周边形状，这导致相对较少的“死空间”，其中不产生穿孔穿透器。 在操作中，模块提供相对致密的喷射模式，并且显着减少了可能堵塞穿孔的后爆炸碎片的数量和/或需要补救清理或重复穿孔。

公开(公告)号：US20090169636A1

公开(公告)日：2009-07-02

申请号：US11710250

申请日：2007-02-24

Applicant: Derek O' Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

Inventor： Derek O' Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/39 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/21 ,  A61K39/29 ,  A61K39/145 ,  A61K39/10 ,  A61K39/05 ,  A61K39/08 ,  A61P37/04

CPC classification number: A61K9/1652 ,  A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093

Abstract: Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

Abstract translation: 本文描述了包含进一步包含生物可降解聚合物的微粒的免疫原性组合物。 微粒组合物还包含阳离子多糖和选自抗原，免疫佐剂及其组合的免疫物质。 还描述了制备这样的组合物的方法和施用这样的组合物的方法。 还描述了将免疫物质从微粒释放速率调节的方法。 这些方法包括改变阳离子多糖相对于微粒内生物可降解聚合物的比例。

公开(公告)号：US20090035326A1

公开(公告)日：2009-02-05

申请号：US12092379

申请日：2006-11-01

Applicant: Mario Contorni ,  Manmohan Singh ,  Derek O'Hagan

Inventor： Mario Contorni ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K39/385 ,  A61K47/04 ,  A61P31/04 ,  A61P31/16

CPC classification number: A61K39/02 ,  A61K39/095 ,  A61K2039/55505

Abstract: Calcium phosphate is used as an adjuvant, with a high degree of antigen adsorption to the adjuvant. The invention is particularly useful for adjuvanting conjugated capsular saccharide antigens. Buffers, such as phosphate or histidine buffers, can advantageously be used in combination with the calcium phosphate, and compositions may have a pH in the range of 5.5 to 7.5.

Abstract translation: 使用磷酸钙作为佐剂，对佐剂具有高度的抗原吸附。 本发明特别可用于佐剂结合的荚膜糖抗原。 缓冲剂，例如磷酸盐或组氨酸缓冲液，可以有利地与磷酸钙组合使用，组合物的pH可以在5.5-7.5的范围内。

公开(公告)号：US20080026071A1

公开(公告)日：2008-01-31

申请号：US11653792

申请日：2007-01-16

Applicant: Derek O'Hagan ,  Gillis Otten ,  John Donnelly ,  John Polo ,  Susan Barnett ,  Manmohan Singh ,  Jeffrey Ulmer ,  Thomas Dubensky

Inventor： Derek O'Hagan ,  Gillis Otten ,  John Donnelly ,  John Polo ,  Susan Barnett ,  Manmohan Singh ,  Jeffrey Ulmer ,  Thomas Dubensky

IPC: A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K39/125 ,  A61K39/29 ,  A61P31/04 ,  A61P33/00 ,  A61P31/12 ,  A61K9/50 ,  A61K39/215 ,  A61K39/145 ,  A61K39/155

CPC classification number: C12N15/86 ,  A61K9/1647 ,  A61K9/167 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K47/6927 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6093 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2770/36143 ,  Y02A50/388

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. Also provided are microparticles in the form of submicron emulsions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. The surface of the microparticles efficiently adsorb polypeptides, such as antigens, and nucleic acids, such as ELVIS vectors and other vector constructs, containing heterologous nucleotide sequences encoding biologically active macromolecules, such as polypeptides, antigens, and adjuvants. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and uses of the microparticle compositions for vaccines are also provided.

Abstract translation: 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 还提供了具有可代谢油和乳化剂的油滴乳液的亚微米乳液形式的微粒。 微粒的表面有效地吸收多肽，如抗原和核酸，如ELVIS载体和其他载体构建体，其含有编码生物活性大分子如多肽，抗原和佐剂的异源核苷酸序列。 还提供了刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及微粒组合物用于疫苗的用途。

公开(公告)号：US20050208143A1

公开(公告)日：2005-09-22

申请号：US11113861

申请日：2005-04-25

Applicant: Derek O' Hagan ,  Manmohan Singh ,  Gary Ott ,  John Barackman ,  Jina Kazzaz

Inventor： Derek O' Hagan ,  Manmohan Singh ,  Gary Ott ,  John Barackman ,  Jina Kazzaz

IPC: A61K9/00 ,  A61K9/16 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K39/245 ,  A61K39/39 ,  A61K48/00 ,  A61K9/14 ,  A61K39/38

CPC classification number: A61K39/245 ,  A61K9/1647 ,  A61K9/167 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2740/16111 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2770/24211 ,  C12N2770/24234

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants.

公开(公告)号：US20050123599A1

公开(公告)日：2005-06-09

申请号：US11042745

申请日：2005-01-25

Applicant: Gary Ott ,  Manmohan Singh ,  Derek O'Hagan

Inventor： Gary Ott ,  Manmohan Singh ,  Derek O'Hagan

IPC: A61K9/00 ,  A61K9/107 ,  A61K47/26 ,  C07H15/24 ,  A61K48/00 ,  A61K9/127 ,  A61K39/12 ,  A61K39/145 ,  A61K39/21

CPC classification number: A61K9/0019 ,  A61K9/107 ,  A61K47/26 ,  C07H15/24

Abstract: The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable oil comprising at least one branched or unbranched long-chain hydrocarbon moiety; (c) a steroid; and (d) a saponin.

Abstract translation: 本发明涉及靶向免疫细胞和/或体液臂的新型佐剂组合物。 根据本发明的一个实施方案，提供了一种水包油佐剂组合物，其包含：（a）水; （b）包含至少一个支链或非支链长链烃部分的可代谢油; （c）类固醇; 和（d）皂苷。

公开(公告)号：US06855492B2

公开(公告)日：2005-02-15

申请号：US10211025

申请日：2002-08-02

Applicant: Derek O'Hagan ,  Gary Van Nest ,  Gary S. Ott ,  Manmohan Singh

Inventor： Derek O'Hagan ,  Gary Van Nest ,  Gary S. Ott ,  Manmohan Singh

IPC: A61K9/00 ,  A61K9/107 ,  A61K9/16 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/29 ,  A61K39/39 ,  A61P31/00 ,  A61P31/12 ,  A61P37/04 ,  C12Q1/00

CPC classification number: A61K39/29 ,  A61K9/1075 ,  A61K9/1647 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N2740/16134 ,  C12N2770/24234 ,  Y02A50/401 ,  Y02A50/412 ,  Y10S977/802 ,  Y10S977/915 ,  Y10S977/918

Abstract: Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.

Abstract translation: 提供了包含与亚微米水包油乳剂组合的具有包埋或吸附的抗原的可生物降解的微粒的组合物。 还提供了免疫方法，其包括给予脊椎动物受试者（a）亚微米水包油乳剂，和（b）治疗有效量的包埋在微粒中的选择的抗原。

公开(公告)号：US06306405B1

公开(公告)日：2001-10-23

申请号：US09564416

申请日：2000-05-02

Applicant: Derek O'Hagan ,  Gary Van Nest ,  Gary S. Ott ,  Manmohan Singh

Inventor： Derek O'Hagan ,  Gary Van Nest ,  Gary S. Ott ,  Manmohan Singh

IPC: A61K4500

CPC classification number: A61K39/29 ,  A61K9/1075 ,  A61K9/1647 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N2740/16134 ,  C12N2770/24234 ,  Y02A50/401 ,  Y02A50/412 ,  Y10S977/802 ,  Y10S977/915 ,  Y10S977/918

Abstract: Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.

Abstract translation: 提供了包含与亚微米水包油乳剂组合的具有包埋或吸附的抗原的可生物降解的微粒的组合物。 还提供了免疫方法，其包括给予脊椎动物受试者（a）亚微米水包油乳剂，和（b）治疗有效量的包埋在微粒中的选择的抗原。