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公开(公告)号：US11583643B2
公开(公告)日：2023-02-21
申请号：US15881372
申请日：2018-01-26
发明人： Daniel Buck , Paul Prendergast , Declan Walsh
IPC分类号： A61M15/00 , A61P11/06 , A61P11/00 , A61K9/00 , A61K31/439 , A61K31/569 , A61K47/06 , A61M15/08 , B65D83/38 , B65D83/54
摘要： An inhaler (10) for the inhalation of inhalable substances comprise: a canister (50) having an interior reservoir (84) containing pressurised inhalable substances including fluid; a metering valve (52) including a metering chamber (82) and a valve stem (54) defining a communication path between the metering chamber and the interior reservoir, the communication path (86) including an opening (106) configured to permit flow between a transfer space inside the valve stem and the interior reservoir, the interior reservoir being arranged for orientation above the metering chamber whereby gas such as air located within the metering chamber is replaced with liquid from the interior reservoir.
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公开(公告)号：US20230012966A1
公开(公告)日：2023-01-19
申请号：US17949483
申请日：2022-09-21
发明人： Daniel BUCK , Paul PRENDERGAST , Declan WALSH
IPC分类号： A61M15/00 , B65D41/04 , A61K9/00 , A61M15/08 , B65D55/16 , A61K31/569 , A61P11/00 , A61P11/06 , A61K31/439
摘要： An inhaler (10) has a main body for accommodating a medicament reservoir (84), a canister fire system for moving a canister (50) to release a dose in response to air flow, a cap housing (12) for enclosing the canister fire system and canister within an interior chamber defined by the main body (14) and a cap housing, wherein a lock system (250) is provided for locking the cap housing on the main body.
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公开(公告)号：US20220347404A1
公开(公告)日：2022-11-03
申请号：US17864582
申请日：2022-07-14
IPC分类号： A61M15/00 , A61B5/00 , A61K31/138 , C07K16/42 , C07K16/24 , C07K16/28 , A61B5/08 , G16H20/10 , G16H50/30 , G16H50/70
摘要： Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters.
The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.-
公开(公告)号：US11439777B2
公开(公告)日：2022-09-13
申请号：US16240983
申请日：2019-01-07
发明人： Enrique Calderon Oliveras , Carl L. Lewis , Symon D'Oyly Cotton , Steven D. Gardner , Robert O. Kivlin
摘要： A device for delivering medication to a user may include a main body, an electronics module, and a slider. The main body may include a mouthpiece, a medication reservoir, and a mouthpiece cover, where the mouthpiece cover may be hinged to the main body. The electronics module may include a communication circuit, a pressure sensor, and a switch. The slider may be configured to engage the switch when the mouthpiece cover moves from a closed position to an open position. The switch may be configured to switch the electronics module from an off state or a sleep state to an active state. The electronics module may be configured to never return to the off state after the mouthpiece cover is moved to expose the mouthpiece for the first time by the user.
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公开(公告)号：US11419995B2
公开(公告)日：2022-08-23
申请号：US16919628
申请日：2020-07-02
IPC分类号： A61M15/00 , A61B5/00 , A61B5/08 , G16H20/10 , G16H50/30 , G16H50/70 , A61K31/138 , C07K16/42 , C07K16/24 , C07K16/28 , A61M11/00
摘要： Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.
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公开(公告)号：US11357935B2
公开(公告)日：2022-06-14
申请号：US16421451
申请日：2019-05-23
发明人： Enrique Calderon Oliveras , Carl L. Lewis , Symon D'Oyly Cotton , Steven D. Gardner , Robert O. Kivlin , Amir Zur
摘要： A system may include a mobile application residing on an external device and an inhalation device. The inhalation device may include a mouthpiece, a mouthpiece cover, medicament, and an electronics module comprising a processor. The inhalation device may be configured to both prepare a dose of medicament for delivery to a user and cause the processor to transition between power states when the mouthpiece cover is moved from a closed position to an open position to expose the mouthpiece. The electronics module or the mobile application may be configured to generate usage events based on usage of the inhalation device by the user. The electronics module may also include a pressure sensor, and the electronics module or the mobile application may be configured to determine whether a usage event is a good inhalation event, a fair inhalation event, or a no inhalation event based on feedback from the pressure sensor.
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公开(公告)号：US20220062568A1
公开(公告)日：2022-03-03
申请号：US17501312
申请日：2021-10-14
IPC分类号： A61M15/00
摘要： A system may limit the number of times an inhalation device transmits inhalation data to a single time to reduce the battery usage of the inhalation device. The system may include an inhalation device that has medicament and an electronics module. The system may limit the number of times the inhalation device transmits new inhalation data to any mobile device to a single time by causing the server to receive the new inhalation data from one of the mobile devices and causing the server to transmit the new inhalation data to other of the mobile devices prior to the other mobile devices transmitting a request for the new inhalation data to the inhalation device. The inhalation device may include a Quick Response (QR) code, and a mobile application may determine at least one of a medication type or a number of doses of the inhalation device from the QR code.
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公开(公告)号：US20210386946A1
公开(公告)日：2021-12-16
申请号：US17366906
申请日：2021-07-02
发明人： Peter John Crowley , Jan Geert Hazenberg , Daniel Buck , Christopher David Edlin , Hardik Kirtikumar Shah
IPC分类号： A61M15/00
摘要： Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets, e.g. respective blister pockets, of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments. This, in turn, may enable the depth/thickness of the dry powder inhaler to be minimized, and/or additional space to be provided inside the dry powder inhaler for accommodating, for example, use detection and wireless connectivity electronics for sending use detection data to an external device, such as a smartphone.
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公开(公告)号：US11141547B2
公开(公告)日：2021-10-12
申请号：US16008380
申请日：2018-06-14
IPC分类号： A61B5/087 , A61B5/091 , A61M15/00 , A61M11/02 , G16H20/10 , A61B5/00 , A61M16/00 , G16Z99/00
摘要： An inhalation monitoring system includes an inhaler having a medicament delivery apparatus configured to deliver medicament to a user during an inhalation of the user; inhalation monitoring apparatus, configured to, during the inhalation, gather data for determining a measure of the user's lung function and/or lung health; and a processor configured to receive the data from the inhalation monitoring apparatus and, using the data, determine a measure of the user's lung function and/or lung health.
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公开(公告)号：US20210302407A1
公开(公告)日：2021-09-30
申请号：US16482700
申请日：2018-01-30
发明人： Daniel Buck , Declan Walsh , Paul Prendergast
摘要： Disclosed herein is a quality control method for predicting premature degradation in mechanical properties of a series of moulded plastics components, the moulded plastics components being formed from a batch mixture comprising a cross-linkable polymer and a peroxide cross-linking agent. The method comprises selecting a subset of the series of moulded plastics components and obtaining a material specimen from the subset; and then extracting and measuring a residual peroxide content of the specimen. According to the invention, the measured residual peroxide content is representative of a probability of the pre-measuring mature age-related degradation in the entire series of moulded plastics components, and may therefore be compared against a threshold residual peroxide content to determine whether the entire series of components is of acceptable quality.
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