公开(公告)号：US20150299667A1

公开(公告)日：2015-10-22

申请号：US14435016

申请日：2013-10-10

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE

Inventor： Lorenzo PIEMONTI ,  Ilaria CAPUA

IPC: C12N7/00 ,  A61K45/06 ,  A61K39/145 ,  A61K31/215 ,  A61K31/351

CPC classification number: C12N7/00 ,  A61K31/215 ,  A61K31/351 ,  A61K39/12 ,  A61K39/145 ,  A61K45/06 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16133 ,  C12N2760/16134

Abstract: Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. The inventors provide the first evidence of a causal link between influenza virus infection and the development of type 1 diabetes and/or pancreatitis. This causal link between infection and type 1 diabetes and/or pancreatitis provides various therapeutic, prophylactic and diagnostic opportunities.

Abstract translation: 1型糖尿病的特征在于胰腺胰岛素生成β细胞的丧失，导致胰岛素缺乏。 这种β细胞损失的常见原因是自身免疫性破坏。 发明人提供了流感病毒感染与1型糖尿病和/或胰腺炎发展之间因果关系的第一证据。 感染与1型糖尿病和/或胰腺炎之间的这种因果联系提供了各种治疗，预防和诊断的机会。

公开(公告)号：US20150285805A1

公开(公告)日：2015-10-08

申请号：US14440782

申请日：2013-11-05

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE S.R.L.

Inventor： Simone Cenci ,  Francesca Fontana ,  Josè Manuel Garcia Manteiga

IPC: G01N33/574

CPC classification number: G01N33/57426 ,  G01N33/57407 ,  G01N2333/46 ,  G01N2333/47 ,  G01N2800/22 ,  G01N2800/52

Abstract: The present invention relates to a method for the prognosis of Symptomatic Multiple Myeloma (MM) and/or to monitor the response and/or the efficacy of a MM therapy comprising detecting and/or quantifying at least one marker, to relative kit and uses thereof and to relative microarray and use thereof. Markers include C3f peptide or a fragment thereof and/or other metabolites.

Abstract translation: 本发明涉及一种用于预后症状性多发性骨髓瘤（MM）和/或监测MM治疗的应答​​和/或功效的方法，包括检测和/或定量至少一种标记物，以及相关试剂盒及其用途 和相对微阵列及其用途。 标记物包括C3f肽或其片段和/或其它代谢物。