公开(公告)号：US20200087630A1

公开(公告)日：2020-03-19

申请号：US16505774

申请日：2019-07-25

Applicant: Ospedale San Raffaele S.r.l. ,  Istituto Zooprofilattico Sperimentale delle Venezie

Inventor： Lorenzo Piemonti ,  Ilaria Capua

IPC: C12N7/00 ,  A61K45/06 ,  A61K31/351 ,  A61K31/215 ,  A61K39/12 ,  C07K14/005 ,  A61K39/145

Abstract: Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. The inventors provide the first evidence of a causal link between influenza virus infection and the development of type 1 diabetes and/or pancreatitis. This causal link between infection and type 1 diabetes and/or pancreatitis provides various therapeutic, prophylactic and diagnostic opportunities.

公开(公告)号：US20180273912A1

公开(公告)日：2018-09-27

申请号：US15862773

申请日：2018-01-05

Applicant: Ospedale San Raffaele S.r.l. ,  Istituto Zooprofilattico Sperimentale delle Venezie

Inventor： Lorenzo PIEMONTI ,  Ilaria CAPUA

IPC: C12N7/00 ,  A61K31/351 ,  C07K14/005 ,  A61K31/215 ,  A61K39/12 ,  A61K45/06 ,  A61K39/145

CPC classification number: C12N7/00 ,  A61K31/215 ,  A61K31/351 ,  A61K39/12 ,  A61K39/145 ,  A61K45/06 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16133 ,  C12N2760/16134

Abstract: Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. The inventors provide the first evidence of a causal link between influenza virus infection and the development of type 1 diabetes and/or pancreatitis. This causal link between infection and type 1 diabetes and/or pancreatitis provides various therapeutic, prophylactic and diagnostic opportunities.

公开(公告)号：US20150299667A1

公开(公告)日：2015-10-22

申请号：US14435016

申请日：2013-10-10

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLE VENEZIE

Inventor： Lorenzo PIEMONTI ,  Ilaria CAPUA

IPC: C12N7/00 ,  A61K45/06 ,  A61K39/145 ,  A61K31/215 ,  A61K31/351

CPC classification number: C12N7/00 ,  A61K31/215 ,  A61K31/351 ,  A61K39/12 ,  A61K39/145 ,  A61K45/06 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16133 ,  C12N2760/16134

Abstract: Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction. The inventors provide the first evidence of a causal link between influenza virus infection and the development of type 1 diabetes and/or pancreatitis. This causal link between infection and type 1 diabetes and/or pancreatitis provides various therapeutic, prophylactic and diagnostic opportunities.

Abstract translation: 1型糖尿病的特征在于胰腺胰岛素生成β细胞的丧失，导致胰岛素缺乏。 这种β细胞损失的常见原因是自身免疫性破坏。 发明人提供了流感病毒感染与1型糖尿病和/或胰腺炎发展之间因果关系的第一证据。 感染与1型糖尿病和/或胰腺炎之间的这种因果联系提供了各种治疗，预防和诊断的机会。