公开(公告)号：US20220389025A1

公开(公告)日：2022-12-08

申请号：US17761252

申请日：2020-09-21

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  China Pharmaceutical University

发明人： Wenhu DUAN ,  Meiyu GENG ,  Huibin ZHANG ,  Zuoquan XIE ,  Jinpei ZHOU ,  Yifei YANG ,  Xiyuan WANG ,  Xiaojun YANG ,  Yan ZHANG ,  Zhaoxue HU ,  Jian DING

IPC分类号： C07D491/048 ,  C07D519/00 ,  A61P35/00

摘要： Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.

公开(公告)号：US20220362271A1

公开(公告)日：2022-11-17

申请号：US17631731

申请日：2020-08-05

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Guangqiang Sun ,  Xinyi Wang ,  Jing Zhang ,  Teng Feng

IPC分类号： A61K31/702 ,  A61K31/734 ,  A61P19/02 ,  A61P25/28 ,  A61P5/16 ,  A61P5/50

摘要： A use that relates to mannuronic acid oligosaccharides or a composition comprising same in the treatment of Th1-dominance related diseases. The Th1-dominance related diseases may be selected from Multiple Sclerosis, Crohn's disease, Type I Diabetes, Rheumatoid Arthritis, Hashimoto's thyroiditis, vitiligo, Sjögren's Syndrome, Polycystic ovary syndrome, Celiac Disease and Grave's disease, preferably from Multiple Sclerosis, Crohn's disease and Rheumatoid Arthritis.

公开(公告)号：US11406659B2

公开(公告)日：2022-08-09

申请号：US17256854

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/734 ,  A61K31/7016 ,  A61K31/702 ,  A61P37/06 ,  A61K31/7012

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.

公开(公告)号：US11406654B2

公开(公告)日：2022-08-09

申请号：US17256807

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/7032 ,  A61P25/16 ,  A61K31/715 ,  A61K31/716

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

公开(公告)号：US11384111B2

公开(公告)日：2022-07-12

申请号：US16474928

申请日：2017-12-27

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Jian Ding ,  Zhenqing Zhang ,  Zhongping Xiao ,  Xiaoguang Du ,  Xianliang Xin

IPC分类号： A61P25/28 ,  A61K31/7032 ,  A61K31/715 ,  C08B37/00 ,  C07H15/04

摘要： The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

公开(公告)号：US20220204518A1

公开(公告)日：2022-06-30

申请号：US17606121

申请日：2020-04-24

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Ao ZHANG ,  Jian DING ,  Hua XIE ,  Zilan SONG ,  Yu XUE ,  Li XING ,  Linjiang TONG ,  Meiyu GENG

IPC分类号： C07D487/14 ,  A61P35/00

摘要： The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.

公开(公告)号：US20220017505A1

公开(公告)日：2022-01-20

申请号：US17358002

申请日：2021-06-25

申请人： ZHEJIANG UNIVERSITY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Rong SHENG ,  Jia LI ,  Dongyan GU ,  Yubo ZHOU ,  Jun WEI ,  Mengmeng ZHANG ,  Yongzhou HU ,  Kaixiang ZHANG ,  Jieyu LIU ,  Weijuan KAN

IPC分类号： C07D413/14 ,  C07D403/12 ,  C07D471/04 ,  C07D239/95 ,  C07D417/12 ,  C07D473/00 ,  C07D401/14 ,  C07D491/107 ,  C07D491/056

摘要： Provided by the present disclosure are an amino quinazolinone and amino isoquinolone derivatives. It is verified by numerous experiments that the compounds provided by the present disclosure have good inhibiting effects on PI3Kα and PI3Kγ, most of the compounds have prominent inhibiting effect on PI3Kα, and show strong growth inhibiting effect on PIK3CA mutant tumor cells such as human breast cancer cell strain (MCF7). Therefore, the amino quinazolinone and amino isoquinolone derivatives according to the present disclosure can be applied in the preparation of anti-tumor and anti-inflammatory medicines, and can be used as PI3Kα inhibitors in the preparation of medicines for treatment of human or animal cell proliferation related tumors, the medicines comprising the derivatives any one or more of pharmaceutically acceptable salts and solvates thereof as well as pharmaceutically acceptable carriers. Formulas a and b are shown as below:

公开(公告)号：US11142543B2

公开(公告)日：2021-10-12

申请号：US16474668

申请日：2017-12-29

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Chenggang Huang ,  Yang Li ,  Hualiang Jiang ,  Yang Xie ,  Fei Guo ,  Zhixiong Li ,  Mingcang Chen ,  Mingyue Zheng ,  Zhaolin Sun ,  Yu Gao ,  Xiaoting Tian ,  Pei Hu ,  Bing Zhang

IPC分类号： C07H17/04 ,  A61P25/24 ,  C07D493/10 ,  C07H17/00

摘要： An antidepressant steroid compound and a preparation method and an application thereof; the structure of said compound is shown in formula (I), and the definition of each substituent is as described in the description and claims. Compound of the present invention may be used in the prevention, treatment, therapy or alleviation of a plurality of diseases and conditions such as depression.

公开(公告)号：US20210309648A1

公开(公告)日：2021-10-07

申请号：US17127350

申请日：2020-12-18

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. ,  TOPHARMAN SHANGHAI CO., LTD.

发明人： Jingshan Shen ,  Yang He ,  Zhen Wang ,  Jianfeng Li ,  Yongjian Liu ,  Jin Suo ,  Guanghui Tian ,  Weiming Chen ,  Feipu Yang ,  Yu Wang ,  Xiangrui Jiang ,  Rongxia Zhang ,  Hualiang Jiang

IPC分类号： C07D409/12

摘要： The present disclosure relates to a maleate salt of a benzothiophene compound, a crystalline form thereof, and a use thereof. Specifically, the present disclosure relates to a compound represented by formula (I-A), a crystalline form A thereof, a preparation method of a pharmaceutical composition including the same, and a use of the pharmaceutical composition in the preparation of drugs for preventing or treating diseases of the central nervous system. The compound represented by formula (I-A) and the crystalline form A thereof in the present disclosure have excellent physical and chemical properties, high oral bioavailability, excellent drugability, and are well-suited for pharmaceutical preparation, application, and preservation.

公开(公告)号：US20210268006A1

公开(公告)日：2021-09-02

申请号：US17256738

申请日：2019-06-28

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28

摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.