公开(公告)号：US20220356202A1

公开(公告)日：2022-11-10

申请号：US17860468

申请日：2022-07-08

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Jian Ding ,  Zhenqing Zhang ,  Zhongping Xiao ,  Xiaoguang Du ,  Xianliang Xin

IPC分类号： C07H15/04 ,  A61P25/28 ,  A61K31/7032 ,  A61K31/715 ,  C08B37/00

摘要： The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

公开(公告)号：US11464794B2

公开(公告)日：2022-10-11

申请号：US17256853

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Zhenqing Zhang ,  Yingshen Jin ,  Zhongping Xiao ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28 ,  A61P29/00

摘要： The present invention relates to an alginic oligosaccharic diacid composition comprising a mannuronic diacid of Formula (IV) or a pharmaceutically acceptable salt thereof, wherein n is an integer selected from 1 to 9, m is selected from 0, 1 or 2, m′ is selected from 0 or 1, and wherein the total weight of alginic oligosaccharic diacid wherein n=1-5 accounts for more than 60% of the total weight of the composition; the total weight of guluronic acids accounts for less than 50% of the total weight of the composition.

公开(公告)号：US11406651B2

公开(公告)日：2022-08-09

申请号：US17256738

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61P25/28

摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.

公开(公告)号：US11406653B2

公开(公告)日：2022-08-09

申请号：US17256950

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61P25/06 ,  A61K31/715 ,  A61K31/7032 ,  A61K31/702 ,  A61P25/04 ,  A61K31/7004 ,  A61K31/7016

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.

公开(公告)号：US11406659B2

公开(公告)日：2022-08-09

申请号：US17256854

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/734 ,  A61K31/7016 ,  A61K31/702 ,  A61P37/06 ,  A61K31/7012

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of inflammation.

公开(公告)号：US11406654B2

公开(公告)日：2022-08-09

申请号：US17256807

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Xiaoguang Du ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/7032 ,  A61P25/16 ,  A61K31/715 ,  A61K31/716

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.

公开(公告)号：US11384111B2

公开(公告)日：2022-07-12

申请号：US16474928

申请日：2017-12-27

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Jian Ding ,  Zhenqing Zhang ,  Zhongping Xiao ,  Xiaoguang Du ,  Xianliang Xin

IPC分类号： A61P25/28 ,  A61K31/7032 ,  A61K31/715 ,  C08B37/00 ,  C07H15/04

摘要： The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m′ is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

公开(公告)号：US11174237B2

公开(公告)日：2021-11-16

申请号：US16623297

申请日：2018-05-31

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES ,  FUKANG (SHANGHAI) HEALTH TECHNOLOGY CO., LTD.

发明人： Chunhao Yang ,  Zehong Miao ,  Cun Tan ,  Xiajuan Huan ,  Jian Ding ,  Yi Chen

IPC分类号： C07D307/84

摘要： Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs.

公开(公告)号：US20210322449A1

公开(公告)日：2021-10-21

申请号：US17256889

申请日：2019-06-28

申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61K31/702 ,  A61K31/7012 ,  A61K31/7016 ,  A61K31/715 ,  A61P3/10

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.

公开(公告)号：US20210261539A1

公开(公告)日：2021-08-26

申请号：US16967664

申请日：2019-02-01

申请人： Shanghai Haihe Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Lin Xia ,  Meiyu Geng ,  Yan Ye ,  Jian Ding ,  Qiong Zhang ,  Aijun Shen ,  Ying Huang ,  Hongchun Liu ,  Haoran Yang ,  Jing Ai ,  Minmin Zhang

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D403/04 ,  C07D498/04 ,  C07D401/14 ,  C07D487/04 ,  C07D413/14

摘要： The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.