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116 条记录 (耗时 0.035 秒)

    Analgesic and refreshing herbal composition and a process for preparing the same
    93.
    发明授权
    Analgesic and refreshing herbal composition and a process for preparing the same 失效
    镇痛和清爽的草药成分及其制备方法

    公开(公告)号：US06531115B1

    公开(公告)日：2003-03-11

    申请号：US09752822

    申请日：2001-01-03

    申请人： Anil Kumar Singh ,  Ratan Lal Bindra ,  Rashmi Gupta ,  Yogendra Nath Shukla ,  Sushil Kumar

    发明人： Anil Kumar Singh ,  Ratan Lal Bindra ,  Rashmi Gupta ,  Yogendra Nath Shukla ,  Sushil Kumar

    IPC分类号： A61K726

    CPC分类号： A61Q11/00 ,  A61K8/347 ,  A61K8/922 ,  A61K8/97 ,  A61K31/355 ,  A61K36/15 ,  A61K36/235 ,  A61K36/53 ,  A61K36/534 ,  A61K36/61 ,  A61K36/67 ,  A61K2300/00

    摘要： The invention provides an analgesic and refreshing herbal composition useful as dentrifrices, said composition comprising 50-60% Wt. of betle extract (from Piper betle leaves); 40-50% Wt. of one or more group I essential oil selected from Levender officinal, Dementholised oil (ex-Mentha arvensis), Fennel oil and Ocimum gratissimum; 3.5-6% Wt. of one or more group II essential oils and their isolates selected from Ocimum Sanctum, Pulegone (ex Mentha pulegonium), Carvone (ex. Dill seed) and Menthol (ex. Mentha arvensis); 1-5% Wt. of one or more group III essential oils selected from Camphor, turpentine oil, Cedarwood oil and Safrole oil, along with 0.5-2% Wt. of Thymol and 0.25-1% Wt. of preservative/antioxidant, and a process for preparing the composition.

    摘要翻译： 本发明提供了可用作牙齿的止痛和清新的草药组合物，所述组合物包含50-60％重量。 le提取物（来自Pi le叶）; 40-50％重量 选自Levender officinal，Dementholised oil（ex-Mentha arvensis），茴香油和Ocimum gratissimum的一种或多种I组精油; 3.5-6％重量 一种或多种II类精油及其分离物，其选自Ocimum Sanctum，Pulegone（Mentha pulegonium），Carvone（例如莳萝种子）和薄荷醇（例如Mentha arvensis）; 1-5％重量 一种或多种选自樟脑，松节油，雪松油和霞石油的III族精油以及0.5-2％重量。 百里香酚和0.25-1％重量。 防腐剂/抗氧化剂，以及制备该组合物的方法。

    Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model
    96.
    发明授权
    Method for screening of potential anti-epileptic drugs using a Drosophila melanogaster model 失效
    使用黑腹果蝇模型筛选潜在的抗癫痫药物的方法

    公开(公告)号：US06291739B1

    公开(公告)日：2001-09-18

    申请号：US09535517

    申请日：2000-03-24

    申请人： Abhay Sharma ,  Sushil Kumar

    发明人： Abhay Sharma ,  Sushil Kumar

    IPC分类号： G01N3300

    CPC分类号： A01K67/033

    摘要： The invention relates to a method for screening anti-epileptic drugs using fruit fly Drosophila melanogaster by generating single and double mutant lines of K+ channel genes in Drosophila melanogaster, culturing mutant lines on Drosophila medium under standard conditions, identifying the mutants, separating male flies under ether anesthesia, supplying the mutant males with medium containing each of the four antiepileptic drugs, phenobarbital, phenytoin, carbaamazepine and valproate, separately, administering ether anesthesia to the drug treated flies and examining their leg shaking intensity under stereomicroscope, observing the antiepileptic effect in the drug treated males wherein a reduced intensity of leg shaking, compared to leg shaking in normally fed etherized males, is indicative of antiepileptic activity in the drug.

    摘要翻译： 本发明涉及一种通过在果蝇中产生K +通道基因的单突变和双重突变体系，在果蝇培养基上培养突变体系，鉴定突变体，分离雄性苍蝇的本发明涉及使用果蝇黑腹果蝇筛选抗癫痫药物的方法 乙醚麻醉，分别向四种抗癫痫药物，苯巴比妥，苯妥英，卡马西平和丙戊酸各自的培养基中供应突变体雄性，对药物处理的苍蝇进行乙醚麻醉，并在立体显微镜下观察其腿部振动强度，观察其抗癫痫作用 药物治疗的男性，其中与正常喂养的被熟化的雄性的腿部颤动相比，腿部抖动的强度降低，表明药物中的抗癫痫活性。

    Process for the production of 4-aryl-2 butanols from Taxus wallichiana
    98.
    发明授权
    Process for the production of 4-aryl-2 butanols from Taxus wallichiana 有权
    从Taxus wallichiana生产4-芳基-2丁醇的方法

    公开(公告)号：US06184367B2

    公开(公告)日：2001-02-06

    申请号：US09358113

    申请日：1999-07-21

    申请人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    发明人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    IPC分类号： C07C3982

    CPC分类号： C07H15/18 ,  C07C37/004 ,  C07H1/08 ,  C07C39/11

    摘要： The present invention provides a process for the production of two molecules of 4-aryl-2 butanols having the general formula 1 given below: Wherein R═H or glucose from the leaves of Taxus wallichiana, which comprises: (a) defatting air dried, pulverized leaves with aliphatic hydrocarbon solvents, (b) extracting the defatted leaves with chlorinated solvents and polar solvent successively at room temperature, (b) concentrating the chlorinated solvent soluble faction to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvents, (d) acidifying the alkali layer with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate phase to give compound of formula 1 where R═H, (e) concentrating the polar solvent fraction from step (b) to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvent, and (f) acidifying the alkali phase with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate to give compound of formula 1 where R=glucose.

    摘要翻译： 本发明提供了一种生产具有下列通式1的两分子的4-芳基-2丁醇的方法：其中R = H或来自红豆杉叶的葡萄糖，其包括：（a）将空气干燥脱脂， 用脂肪族烃溶剂粉碎叶片，（b）在室温下连续用氯化溶剂和极性溶剂萃取脱脂叶，（b）将氯化溶剂可溶部分浓缩至残留物，用碱水溶液处理残留物，用氯化物萃取 溶剂，（d）用无机酸酸化碱层并用乙酸乙酯萃取并浓缩乙酸乙酯相，得到其中R = H的式1化合物，（e）将步骤（b）的极性溶剂级分浓缩至残余物 并用碱水溶液处理残留物，用氯化溶剂萃取，（f）用无机酸酸化碱相，用乙酸乙酯萃取 并浓缩乙酸乙酯，得到其中R =葡萄糖的式1化合物。

    Tissue culture process for producing a large number of viable mint plants in vitro from internodal segments
    100.
    发明授权
    Tissue culture process for producing a large number of viable mint plants in vitro from internodal segments 失效
    组织培养方法，用于在体外从节间段产生大量可行的薄荷植物

    公开(公告)号：US5898001A

    公开(公告)日：1999-04-27

    申请号：US792545

    申请日：1997-01-31

    申请人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    发明人： Sushil Kumar ,  Shiv Kumar Gupta ,  Savithri Bhat ,  Rakesh Tuli

    IPC分类号： A01H4/00 ,  C12N5/04 ,  C12N5/00

    CPC分类号： A01H4/008

    摘要： The present invention relates to a tissue culture process for producing a large number of viable mint plants in vitro. The process of the present invention employs specified pieces of an internodal segment of the stem of the mint plant as the starting material and identifies medium and culture conditions for producing a large number of plants. Such plants can be used for micropropagation, selection of mutants, production of plants with altered levels of endogenous secondary metabolites and for genetic engineering.

    摘要翻译： 本发明涉及用于在体外生产大量活的薄荷植物的组织培养方法。 本发明的方法使用薄荷植物的茎的节间段的指定片段作为起始材料，并且识别用于生产大量植物的培养条件。 这样的植物可以用于微繁殖，突变体的选择，产生具有改变的内源性次级代谢物水平的植物和遗传工程。