公开(公告)号：US4265874A

公开(公告)日：1981-05-05

申请号：US143644

申请日：1980-04-25

申请人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

发明人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

IPC分类号： B01J4/04 ,  A61K9/00 ,  A61K9/32 ,  A61K9/46 ,  A61J1/00

CPC分类号： A61K9/0004

摘要： A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.

摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室的半透壁，壳体（1）在中性和酸性条件下表现出有限溶解度的药物; 和（2）能够在酸性存在下在使用环境中放出二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。

公开(公告)号：US4217898A

公开(公告)日：1980-08-19

申请号：US953907

申请日：1978-10-23

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61K9/00 ,  A61M31/00

CPC分类号： A61K9/0004 ,  A61M31/002

摘要： A system is disclosed for delivering an active agent to a fluid environment of use. The system comprises a microporous reservoir, an active agent housed in the reservoir, a surface that defines an exposed area of the reservoir for releasing agent from the reservoir to the environment, and a wall impermeable to both fluid and agent that surrounds the remaining, unexposed surfaces of the reservoir. In operation, when the system is in the environment with the exposed surface presented to fluid, fluid enters the system through the exposed surface causing agent to diffuse from within the system, which agent is released from the exposed surface of the system to the environment at a controlled rate over time.

摘要翻译： 公开了一种用于将活性剂递送到使用的流体环境的系统。 该系统包括微孔储存器，容纳在储存器中的活性剂，限定储存器的暴露区域以从储存器释放到环境中的表面，以及围绕剩余的未曝光的不透液体的壁 水库表面。 在操作中，当系统处于暴露表面呈现流体的环境中时，流体通过暴露的表面进入系统，使得试剂从系统内扩散，该试剂从系统的暴露表面释放到环境中 随着时间的推移受到控制。

公开(公告)号：US4111203A

公开(公告)日：1978-09-05

申请号：US744089

申请日：1976-11-22

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61F9/00 ,  A61K9/00 ,  A61M31/00

CPC分类号： A61F9/0017 ,  A61K9/0004

摘要： An osmotic system for delivering a beneficial agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway through the wall for delivering agent from the compartment. The wall is formed of a material permeable to the passage of an external fluid and impermeable to the passage of agent. The compartment contains an agent that is soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the compartment contains an agent that has limited solubility in the fluid and exhibits a limited osmotic pressure gradient across the wall against the fluid. The compartment also contains means for increasing the amount of agent delivered from the system. The means comprises a film surrounding an osmagent with the film formed of a material permeable to fluid, impermeable to osmagent and movable from an initial to an expanded state. In operation, agent is delivered from the system through the passageway at a controlled rate by fluid being imbibed through the wall into the compartment to produce a solution or suspension containing agent, and for imbibition by the means causing it to concentrate the solution or suspension, expand and fill the compartment, whereby agent is released at a rate controlled by the permeability of the wall, the oosmotic pressure gradient across the wall, and the rate of imbibition and expansion of the means over a prolonged period of time.

公开(公告)号：US4096238A

公开(公告)日：1978-06-20

申请号：US775774

申请日：1977-03-09

申请人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

发明人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0051 ,  A61F6/14 ,  A61F6/144 ,  A61F9/0017 ,  A61K9/0004 ,  A61K9/0039

摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.

摘要翻译： 公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。 该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。 所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。 在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。 该试剂可溶于流体并且表现出跨越半透性壁对流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，其表现出穿过半透壁的渗透压梯度抵抗 流体。 在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生 将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度 设备。

公开(公告)号：US4093708A

公开(公告)日：1978-06-06

申请号：US775988

申请日：1977-03-09

申请人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

发明人： Alejandro Zaffaroni ,  Alan S. Michaels ,  Felix Theeuwes

IPC分类号： A61F6/14 ,  A61F9/00 ,  A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0051 ,  A61F6/14 ,  A61F6/144 ,  A61F9/0017 ,  A61K9/0004 ,  A61K9/0039

摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.

摘要翻译： 公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。 该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。 所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。 在选择的环境中侵蚀以改变装置的释放速率图案的图案率控制材料层被承载在远离隔室的半透壁上。 该试剂可溶于流体并且表现出跨越半透性壁对流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，其表现出穿过半透壁的渗透压梯度抵抗 流体。 在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生 将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度 设备。

公开(公告)号：US4034758A

公开(公告)日：1977-07-12

申请号：US683275

申请日：1976-05-05

申请人： Felix Theeuwes

发明人： Felix Theeuwes

IPC分类号： A61F6/14 ,  A61K9/00 ,  A61M31/00

CPC分类号： A61F6/144 ,  A61K9/0004

摘要： An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding in at least a part, a reservoir containing agent. The wall is formed of a material permeable to an external fluid and impermeable to agent. The reservoir is formed of a microporous material permeable to agent and fluid, and having at least one micropore that is a passageway for release of agent. The agent is soluble in the fluid and exhibits an osmotic pressure gradient against the fluid, or the agent has limited solubility in the fluid and is admixed with an osmotically effective compound soluble in fluid that exhibits an osmotic pressure gradient against fluid. In operation, agent is released by fluid permeating through the wall into the reservoir producing a solution of agent or a solution of compound containing agent, which solution in either instance is released through the micropore to the exterior of the device.

摘要翻译： 公开了用于递送活性剂的渗透装置。 该装置包括围绕至少一部分的壁，储存器容纳剂。 该壁由可渗透外部流体的材料形成，并且不能透过试剂。 储存器由可渗透试剂和流体的微孔材料形成，并且具有至少一个微孔，其是用于释放试剂的通道。 该试剂可溶于流体并且对流体表现出渗透压梯度，或者该试剂在流体中具有有限的溶解度，并且与可溶于液体的渗透性有效化合物混合，其表现出对流体的渗透压梯度。 在操作中，通过渗透到壁中的流体将液体释放到储存器中，产生试剂或化合物含量溶液的溶液，该溶液在任一情况下通过微孔释放到装置的外部。

公开(公告)号：US4016880A

公开(公告)日：1977-04-12

申请号：US663665

申请日：1976-03-04

申请人： Felix Theeuwes ,  Nalinkant C. Damani

发明人： Felix Theeuwes ,  Nalinkant C. Damani

IPC分类号： B01J4/04 ,  A61F9/00 ,  A61K9/00 ,  A61K9/36 ,  A61K9/52 ,  A61M31/00

CPC分类号： A61K9/0004 ,  A61F9/0017

摘要： Osmotically driven active agent dispenser for use in an aqueous environment that pumps a solution of active agent, such as a drug, at a predetermined, constant rate. The dispenser is in the form of a coated tablet comprising: a core of an osmotically effective active agent composition; and an inexpandable wall that encloses the core, has a controlled permeability to water and includes means, such as brittleness or sites of structural weakness, that is responsive to the pressure generated within the dispenser by imbibition of water from the environment by the core through the wall to form at least one, and usually many, passageways in situ in the wall through which the active agent composition in solution is pumped osmotically at a rate that is substantially dependent of the rate at which water is being imbibed into the dispenser.

摘要翻译： 渗透驱动的活性剂分配器，用于以预定的恒定速率泵送活性剂如药物的溶液的水性环境。 分配器是包衣片剂的形式，包括：渗透有效的活性剂组合物的核心; 并且包围核心的廉价的壁具有受控的水渗透性，并且包括诸如脆性或结构弱点的装置，该装置通过由核心通过芯部吸收来自环境的水来响应分配器内产生的压力 壁在壁中原位形成至少一个通常多个通道，通过该通道，溶液中的活性剂组合物通过渗透液体以基本上取决于水被吸入分配器的速率的速率被泵送。

公开(公告)号：US07470267B2

公开(公告)日：2008-12-30

申请号：US10137661

申请日：2002-05-01

申请人： Ashok V. Joshi ,  Strahinja K. Zecevic ,  Sai Bhavaraju ,  Felix Theeuwes ,  Jeremy Corwin Wright

发明人： Ashok V. Joshi ,  Strahinja K. Zecevic ,  Sai Bhavaraju ,  Felix Theeuwes ,  Jeremy Corwin Wright

IPC分类号： A61K9/22

CPC分类号： A61M5/1452 ,  A61K9/0004 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/14526 ,  A61M2005/14513

摘要： A fluid delivery device, comprising an electrochemical pump, wherein the pump is capable of transporting water; a pump product chamber, wherein the pump product chamber is capable of retaining water generated from the pump; a displaceable member positioned between the pump product chamber and a reservoir, wherein the displaceable member is controllably displaced upon generation of water from the electrochemical pump; a reservoir, wherein the reservoir is capable of containing a fluid which is delivered upon displacement of the displaceable member; and an housing for containing the pump, the pump product chamber, the displaceable member, and the reservoir.

摘要翻译： 一种流体输送装置，包括电化学泵，其中所述泵能够输送水; 泵产品室，其中所述泵产品室能够保留从所述泵产生的水; 定位在所述泵产品室和储存器之间的可移位构件，其中所述可移位构件在从所述电化学泵产生水时可控地移位; 储存器，其中所述储存器能够容纳在所述可移位构件移位时被输送的流体; 以及用于容纳泵，泵产品室，可移动构件和储存器的壳体。

公开(公告)号：US07438701B2

公开(公告)日：2008-10-21

申请号：US09917181

申请日：2001-07-26

申请人： Felix Theeuwes ,  Su Il Yum

发明人： Felix Theeuwes ,  Su Il Yum

IPC分类号： A61M29/00

CPC分类号： A61M25/00 ,  A61M25/0043 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1086

摘要： The invention provides a local concentration management system (LCMS) for delivery of highly concentrated therapeutic agent formulations. The LCMS comprises a device comprising an elongate body defining a lumen between its proximal and distal ends, and a diffuser element, a dilutor element, or both. The diffuser element, which is selectively permeable to the agent, is operatively associated with the elongate body so that agent flows through the elongate body, and into and through the diffuser element to exit the system. The dilutor element can be operatively associated with the system to be in fluid communication with the elongate body lumen, a diffusion space defined by a diffuser element inner wall, or both. The dilutor element is selectively water permeable, but substantially impermeable to agent, to provide for dilution of the agent during transit through the system. The LCMS system is designed to disperse and/or dilute the drug delivery stream.

摘要翻译： 本发明提供了用于递送高度浓缩的治疗剂制剂的局部浓度管理系统（LCMS）。 LCMS包括装置，其包括在其近端和远端之间限定内腔的细长主体，以及扩散器元件，稀释元件或两者。 对试剂选择性渗透的扩散器元件可与细长体可操作地连接，使得试剂流过细长体并进入并通过扩散器元件以离开系统。 稀释元件可以与系统可操作地相关联以与细长体腔流体连通，由扩散器元件内壁或两者限定的扩散空间。 稀释剂元件选择性地是水可渗透的，但是对试剂基本上是不可渗透的，以便在通过系统运输期间提供试剂的稀释。 LCMS系统被设计成分散和/或稀释药物输送流。

公开(公告)号：US07371229B2

公开(公告)日：2008-05-13

申请号：US10353769

申请日：2003-01-28

申请人： Felix Theeuwes ,  Jeremy Corwin Wright ,  Stahinja K. Zecevic

发明人： Felix Theeuwes ,  Jeremy Corwin Wright ,  Stahinja K. Zecevic

IPC分类号： A61K9/22

CPC分类号： H01M2/0202 ,  A61M2005/14513 ,  A61N1/30 ,  B01D61/427 ,  H01M10/425 ,  H01M10/484

摘要： The present invention is disclosed herein as an electrochemical cell having a cell housing with a first half cell and a second half cell, and an ion selective membrane between the cells. The electrochemical cell further has a first electrode positioned within the first half cell, a second electrode positioned within the second half cell, an electrolyte in electrical communication with both the first electrode and the second electrode. The electrodes of the cell are configured so that the electrochemical cell maintains a substantially constant salt concentration level throughout operation. The cell is preferably used in conjunction with an implantable fluid delivery apparatus. A method for using the device is additionally disclosed.

摘要翻译： 本发明在此被公开为具有具有第一半电池和第二半电池的电池壳体的电化学电池以及电池之间的离子选择性膜。 电化学电池还具有位于第一半单元内的第一电极，位于第二半单元内的第二电极，与第一电极和第二电极电连通的电解质。 电池的电极被配置为使得电化学电池在整个操作中保持基本上恒定的盐浓度水平。 细胞优选与可植入流体输送装置结合使用。 另外公开了一种使用该装置的方法。