利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

178 条记录 (耗时 0.055 秒)

    1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS
    92.
    发明申请
    1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS 有权
    1,3-二氢-1H-咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂

    公开(公告)号：US20100056558A1

    公开(公告)日：2010-03-04

    申请号：US12577268

    申请日：2009-10-12

    申请人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Frédéric Stauffer ,  Pascal Furet

    IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P11/00 ,  A61P35/00 ,  A61P29/00

    CPC分类号： C07D471/04

    摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

    摘要翻译： 本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物 用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

    Benzoxazoles and Oxazolopyridines Being Useful as Janus Kinases Inhibitors
    93.
    发明申请
    Benzoxazoles and Oxazolopyridines Being Useful as Janus Kinases Inhibitors 失效
    苯并恶唑和唑吡吉因作为Janus激酶抑制剂有用

    公开(公告)号：US20100009978A1

    公开(公告)日：2010-01-14

    申请号：US12440298

    申请日：2007-09-13

    申请人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    发明人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    IPC分类号： A61K31/423 ,  C07D263/58 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

    CPC分类号： C07D263/58 ,  C07D413/04

    摘要： The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo[5,4-c]pyridine compounds of the formula I given below, as well as salts thereof, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal, especially human, body (especially with regard to a proliferative disease), the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment especially of a protein tyrosine kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation for use in the treatment of such a disease, a method for the treatment of such a disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compounds are of the formula I, wherein the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.

    摘要翻译： 本发明涉及以下给出的式I的2,7-二取代苯并恶唑和2,4-二取代的恶唑并[5,4-c]吡啶化合物及其盐，其制备方法及其在 用于治疗人或动物体的方法，这些化合物用于动物，特别是人体（特别是关于增殖性疾病）的治疗（包括预防）中，单独使用或与一种 或更多其它药物活性化合物 - 用于治疗特别是蛋白质酪氨酸激酶介导的疾病（例如肿瘤疾病）或用于制备用于治疗这种疾病的药物制剂的治疗方法 用于治疗所述疾病的疾病和药物制剂。 所述化合物具有式I，其中符号如说明书中所定义。 该化合物抑制例如JAK2和JAK3。

    Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors
    95.
    发明申请
    Pyrimidinyl Aryl Urea Derivatives Being Fgf Inhibitors 有权
    作为Fgf抑制剂的嘧啶基芳基脲衍生物

    公开(公告)号：US20080312248A1

    公开(公告)日：2008-12-18

    申请号：US12158873

    申请日：2006-12-20

    申请人： Guido Bold ,  Pascal Furet ,  Vito Guagnano

    发明人： Guido Bold ,  Pascal Furet ,  Vito Guagnano

    IPC分类号： A61K31/5377 ,  C07D413/12 ,  A61K31/506 ,  C07D403/12 ,  A61K31/505 ,  C07D239/28 ,  A61P43/00

    CPC分类号： C07D239/48 ,  C07D401/12

    摘要： The invention relates to heteroaryl aryl ureas of the formula IA, wherein the radicals and symbols have the meanings as defined herein, the use of such compounds in the treatment of protein kinase dependent diseases; to pharmaceutical preparations comprising said heteroaryl aryl ureas, to processes for the manufacture of such novel compounds and to methods of treatment comprising the use of such heteroaryl aryl ureas.

    摘要翻译： 本发明涉及式IA的杂芳基芳基脲，其中基团和符号具有本文定义的含义，这些化合物在治疗蛋白激酶依赖性疾病中的用途; 涉及包含所述杂芳基芳基脲的药物制剂，以及制备这些新化合物的方法和包括使用这种杂芳基芳基脲的治疗方法。

    1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors
    99.
    发明申请
    1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors 有权
    1,3-二氢 - 咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂

    公开(公告)号：US20080194579A1

    公开(公告)日：2008-08-14

    申请号：US11913788

    申请日：2006-05-18

    申请人： Carlos Garcia-Echeverria ,  Frederic Stauffer ,  Pascal Furet

    发明人： Carlos Garcia-Echeverria ,  Frederic Stauffer ,  Pascal Furet

    IPC分类号： A61K31/496 ,  C07D471/04 ,  A61P35/00 ,  A61P29/00 ,  A61K31/437

    CPC分类号： C07D471/04

    摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

    摘要翻译： 本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物 用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives
    100.
    发明授权
    4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives 失效
    4-氨基-5-苯基-7-环丁基 - 吡咯并（2,3-d）嘧啶衍生物

    公开(公告)号：US07326699B2

    公开(公告)日：2008-02-05

    申请号：US10477594

    申请日：2002-05-13

    申请人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    发明人： Hans-Georg Capraro ,  Pascal Furet ,  Carlos Garcia-Echeverria ,  Paul William Manley

    IPC分类号： C07D417/06 ,  C07D417/12 ,  C07D487/04 ,  C07D403/06 ,  C07D403/12 ,  C07D413/06 ,  C07D413/12 ,  A61K31/55 ,  A61K31/541 ,  A61K31/5355 ,  A61K31/497 ,  A61K31/519 ,  A61P35/04

    CPC分类号： C07D487/04

    摘要： The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with one or more other pharmaceutically active compounds-for the treatment of a disease, especially a proliferative disease, such as a tumour disease, a method for the treatment of such diseases in mammals, especially in humans, and the use of such a compound-alone or in combination with one or more other pharmaceutically active compounds-for the preparation of a pharmaceutical composition (medicament) for the treatment especially of a proliferative disease, such as a tumour.

    摘要翻译： 本发明涉及新的4-氨基-5-苯基-7-环丁基 - 吡咯并[2,3-d]嘧啶衍生物，其制备方法及其在治疗人或动物体的方法中的应用， 其用途 - 单独使用或与一种或多种其它药学活性化合物组合用于治疗疾病，特别是增殖性疾病，例如肿瘤疾病，哺乳动物，特别是人类中的这些疾病的治疗方法， 以及这种化合物单独使用或与一种或多种其它药学活性化合物组合的用途，用于制备特别是增殖性疾病如肿瘤的药物组合物（药物）。