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    Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors
    2.
    发明授权
    Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors 失效
    苯并恶唑和恶唑啉吡啶可用作甘油激酶抑制剂

    公开(公告)号：US08629168B2

    公开(公告)日：2014-01-14

    申请号：US12440298

    申请日：2007-09-13

    申请人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    发明人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    IPC分类号： C07D263/58 ,  C07D263/60 ,  C07D413/00 ,  C07D498/00 ,  A01N43/76 ,  A61K31/42

    CPC分类号： C07D263/58 ,  C07D413/04

    摘要： The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo[5,4-c]pyridine compounds of the formula I given below, as well as salts thereof, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal, especially human, body (especially with regard to a proliferative disease), the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment especially of a protein tyrosine kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation for use in the treatment of such a disease, a method for the treatment of such a disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compounds are of the formula I, wherein the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.

    摘要翻译： 本发明涉及以下给出的式I的2,7-二取代苯并恶唑和2,4-二取代的恶唑并[5,4-c]吡啶化合物及其盐，其制备方法及其在 用于治疗人或动物体的方法，这些化合物用于动物，特别是人体（特别是关于增殖性疾病）的治疗（包括预防）中，单独使用或与一种 或更多其它药物活性化合物 - 用于治疗特别是蛋白质酪氨酸激酶介导的疾病（例如肿瘤疾病）或用于制备用于治疗这种疾病的药物制剂的治疗方法 用于治疗所述疾病的疾病和药物制剂。 所述化合物具有式I，其中符号如说明书中所定义。 该化合物抑制例如JAK2和JAK3。

    Benzoxazoles and Oxazolopyridines Being Useful as Janus Kinases Inhibitors
    3.
    发明申请
    Benzoxazoles and Oxazolopyridines Being Useful as Janus Kinases Inhibitors 失效
    苯并恶唑和唑吡吉因作为Janus激酶抑制剂有用

    公开(公告)号：US20100009978A1

    公开(公告)日：2010-01-14

    申请号：US12440298

    申请日：2007-09-13

    申请人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    发明人： Marc Gerspacher ,  Pascal Furet ,  Eric Vangrevelinghe

    IPC分类号： A61K31/423 ,  C07D263/58 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

    CPC分类号： C07D263/58 ,  C07D413/04

    摘要： The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo[5,4-c]pyridine compounds of the formula I given below, as well as salts thereof, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, these compounds for use in the treatment (including prophylaxis) of the animal, especially human, body (especially with regard to a proliferative disease), the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment especially of a protein tyrosine kinase mediated disease (such as a tumor disease) or for the manufacture of a pharmaceutical preparation for use in the treatment of such a disease, a method for the treatment of such a disease and a pharmaceutical preparation for the treatment of a disease as mentioned. The compounds are of the formula I, wherein the symbols are as defined in the description. The compounds inhibit, for example, JAK2 and JAK3.

    摘要翻译： 本发明涉及以下给出的式I的2,7-二取代苯并恶唑和2,4-二取代的恶唑并[5,4-c]吡啶化合物及其盐，其制备方法及其在 用于治疗人或动物体的方法，这些化合物用于动物，特别是人体（特别是关于增殖性疾病）的治疗（包括预防）中，单独使用或与一种 或更多其它药物活性化合物 - 用于治疗特别是蛋白质酪氨酸激酶介导的疾病（例如肿瘤疾病）或用于制备用于治疗这种疾病的药物制剂的治疗方法 用于治疗所述疾病的疾病和药物制剂。 所述化合物具有式I，其中符号如说明书中所定义。 该化合物抑制例如JAK2和JAK3。