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![PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION](/abs-image/US/2015/12/10/US20150353563A1/abs.jpg.150x150.jpg)
1.发明申请PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION 有权作为P53 / MDM2相互作用的抑制剂的吡唑并[3,4-D]嘧啶酮化合物公开(公告)号：US20150353563A1
公开(公告)日：2015-12-10
申请号：US14762051
申请日：2014-01-21
Applicant: Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Robert MAH , Keiichi MASUYA , Achim SCHLAPBACH , Andrea VAUPEL
Inventor： Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Robert MAH , Keiichi MASUYA , Achim SCHLAPBACH , Andrea VAUPEL
IPC: C07D487/04 , A61K31/519
CPC classification number: C07D487/04 , A61K31/519
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Abstract translation: 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。
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2.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20150018338A1
公开(公告)日：2015-01-15
申请号：US14324883
申请日：2014-07-07
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC: C07D487/04 , A61K31/5377 , C07D413/14 , C07D471/04 , C07D417/12 , A61K31/553 , C07D413/12
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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![Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors](/abs-image/US/2010/09/14/US07795273B2/abs.jpg.150x150.jpg)
3.发明授权Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors 失效吡唑并[1,5-a]吡啶-3-羧酸，为EphB和VEGFR2激酶抑制剂公开(公告)号：US07795273B2
公开(公告)日：2010-09-14
申请号：US12096260
申请日：2006-12-06
Applicant: Patricia Imbach , Philipp Holzer , Pascal Furet
Inventor： Patricia Imbach , Philipp Holzer , Pascal Furet
IPC: A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC classification number: C07D471/04
Abstract: The invention relates to novel pyrazolo[1,5-a]pyridine-3-carboxylic acid compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新的吡唑并[1,5-a]吡啶-3-羧酸化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方法与其制备方法 用作药物及其组成的药物。
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公开(公告)号：US09403827B2
公开(公告)日：2016-08-02
申请号：US14762037
申请日：2014-01-21
Applicant: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Andrea Vaupel
Inventor： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Robert Mah , Keiichi Masuya , Achim Schlapbach , Andrea Vaupel
IPC: A61K31/522 , C07D473/28
CPC classification number: C07D473/28 , A61K31/522
Abstract: The invention relates to compounds of formula (I): (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of as MDM2 and/or MDM4, and combinations comprising such compounds.
Abstract translation: 本发明涉及式（I）化合物：本文所述的（I）化合物，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM2的活性介导的病症或疾病的用途和用途的方法， 或MDM4，以及包含这些化合物的组合。
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公开(公告)号：US08859586B2
公开(公告)日：2014-10-14
申请号：US14127159
申请日：2012-06-19
Applicant: Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
Inventor： Pascal Furet , Vito Guagnano , Philipp Holzer , Joerg Kallen , Keiichi Masuya , Stefan Stutz
IPC: C07D217/22 , A61K31/47 , A61K31/4725 , A61K31/472 , C07D405/08 , C07D401/08 , C07D217/24
CPC classification number: C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/04 , C07D401/08 , C07D405/08
Abstract: The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
Abstract translation: 本发明涉及式（I）化合物：如申请中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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Patent Agency Ranking
公开(公告)号：US20140113894A1
公开(公告)日：2014-04-24
申请号：US14136679
申请日：2013-12-20
Applicant: Philipp Holzer , Rainer Machauer , Marina Tintelnot-Blomley
Inventor： Philipp Holzer , Rainer Machauer , Marina Tintelnot-Blomley
IPC: C07D413/12
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
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公开(公告)号：US08440693B2
公开(公告)日：2013-05-14
申请号：US12973474
申请日：2010-12-20
Applicant: Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
Inventor： Joerg Berghausen , Nicole Buschmann , Pascal Furet , François Gessier , Joanna Hergovich Lisztwan , Philipp Holzer , Edgar Jacoby , Joerg Kallen , Keiichi Masuya , Carole Pissot Soldermann , Haixia Ren , Stefan Stutz
IPC: A01N37/18 , A61K31/65 , C07D215/00
CPC classification number: C07D239/82 , C07D217/24 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH2 or N—R4 and X, R1, R2, R4, R6, R7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
Abstract translation: 本发明涉及式（I）的取代的含氮双环杂环，其中Z是CH 2或N-R 4，X，R 1，R 2，R 4，R 6，R 7和n如说明书中所定义。 这些化合物适用于治疗由MDM2和/或MDM4或其变体的活性介导的病症或疾病。
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8.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20120302558A1
公开(公告)日：2012-11-29
申请号：US13255036
申请日：2011-07-13
Applicant: Sangamesh Badiger , Murali Chebrolu , Mathias Frederiksen , Philipp Holzer , Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Ulf Neumann , Rita Ramos , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle , Lei Li , Hui Liu , Xin Xiong
Inventor： Sangamesh Badiger , Murali Chebrolu , Mathias Frederiksen , Philipp Holzer , Konstanze Hurth , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Ulf Neumann , Rita Ramos , Heinrich Rueeger , Michael Schaefer , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle , Lei Li , Hui Liu , Xin Xiong
IPC: A61K31/5377 , A61P25/28 , C07D413/12
CPC classification number: C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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公开(公告)号：US20120238560A1
公开(公告)日：2012-09-20
申请号：US13454751
申请日：2012-04-24
Applicant: Philipp HOLZER , Rainer MACHAUER , Marina TINTELNOT-BLOMLEY
Inventor： Philipp HOLZER , Rainer MACHAUER , Marina TINTELNOT-BLOMLEY
IPC: A61K31/5377 , A61P25/28
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
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10.发明申请公开(公告)号：US20110021520A1
公开(公告)日：2011-01-27
申请号：US12842360
申请日：2010-07-23
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LUEOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC: A61K31/5377 , C07D413/12 , C07D419/12 , C07D265/30 , A61K31/5375 , A61P25/28
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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