公开(公告)号：US20090218277A1

公开(公告)日：2009-09-03

申请号：US12399545

申请日：2009-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur ,  Julie Moriarty

IPC分类号： B01D17/038

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US07297272B2

公开(公告)日：2007-11-20

申请号：US10827603

申请日：2004-04-19

申请人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur

发明人： Kyungyoon Min ,  Richard I. Brown ,  Alp Akonur

IPC分类号： B04B3/00 ,  B04B1/06 ,  B04B1/12 ,  B04B7/10 ,  B01D21/26 ,  B01D45/12

CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M2205/128 ,  B04B5/0442 ,  B04B2005/045

摘要： A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

摘要翻译： 使用分离装置和方法来使用用于围绕轴线旋转的分离通道。 这种通道包括径向间隔开的内侧壁部分和外侧壁部分以及端壁部分。 入口将流体输送到通道中。 屏障位于内外侧壁部分的通道中间。 第一流动路径在屏障的上游侧和下游侧之间连通。 收集区域可以位于屏障的下游，用于与第一流动路径通信。 通道的外侧壁部分可以位于其上游部分的径向外侧。 屏障可以沿着通道的轴向长度的大部分连接外侧壁部分。 第一和第二出口流动路径可以允许在障碍物的上游或下游与两者的通道进行通信。

公开(公告)号：US20070000848A1

公开(公告)日：2007-01-04

申请号：US11427402

申请日：2006-06-29

申请人： Kyungyoon Min ,  Richard Brown

发明人： Kyungyoon Min ,  Richard Brown

IPC分类号： B01D33/15

CPC分类号： A61M1/3693 ,  A61M1/3696

摘要： An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.

摘要翻译： 一种装置包括将包含具有不同密度的第一和第二组分的第一流体输送到旋转室中的入口，使得界面在第一位置处在这些部件的至少部分之间形成。 至少一个出口去除第一和第二组分中的至少一个。 控制器适于引入第一流体并且可操作以将界面从第一位置移动到第二位置，并且将界面从朝向第一位置的方向从第二位置移动并将界面返回到第二位置。 该控制器可操作以至少部分地基于界面从第二位置移动到第二位置之间的时间间隔来确定第一或第二组件的流量。 至少一个感测组件适于感测界面的位置。

公开(公告)号：US07087177B2

公开(公告)日：2006-08-08

申请号：US10826086

申请日：2004-04-16

申请人： Kyungyoon Min ,  Richard I. Brown

发明人： Kyungyoon Min ,  Richard I. Brown

IPC分类号： B01D21/26 ,  G01F1/00 ,  B01D21/32 ,  B04B11/00

CPC分类号： A61M1/3693 ,  A61M1/3696

摘要： A separation method comprises introducing a first fluid comprising first and second components having different density into a centrifugal field and allowing an interface to form between at least portions of such components at a first location. The method also comprises moving the interface from the first location to a second location and further comprises introducing the first fluid and removing one of the first and second components at known controlled flow rates so as to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The flow rate of the first or second component may be determined based, at least in part, on the time interval between the interface moving from and returning to the second location. The flow rate may also be based on the weight of the one component removed during the time interval.

摘要翻译： 分离方法包括将包含具有不同密度的第一和第二组分的第一流体引入到离心场中，并允许在第一位置处在这些组分的至少部分之间形成界面。 该方法还包括将界面从第一位置移动到第二位置，并且进一步包括引入第一流体并以已知的受控流速移除第一和第二组分中的一个，以便使接口从第二位置朝向 第一个位置并将界面返回到第二个位置。 至少部分地基于从第二位置移动到返回到第二位置的界面之间的时间间隔来确定第一或第二部件的流量​​。 流量也可以基于在时间间隔期间去除的一个部件的重量。

公开(公告)号：US06582386B2

公开(公告)日：2003-06-24

申请号：US09800129

申请日：2001-03-06

申请人： Kyungyoon Min ,  Richard I. Brown ,  Rohit Vishnoi ,  Tom Westberg ,  Alan Armer

发明人： Kyungyoon Min ,  Richard I. Brown ,  Rohit Vishnoi ,  Tom Westberg ,  Alan Armer

IPC分类号： A61M3700

CPC分类号： A61M1/3687 ,  A61M1/262 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/342 ,  A61M1/3441 ,  A61M1/3672 ,  A61M1/3675 ,  A61M1/3679 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/0427 ,  A61M2205/12

摘要： Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit mounted on a re-usable hardware component or module. The system withdraws blood from a donor or patient, separates the blood into two or more components and further processes or treats the separated component.

公开(公告)号：US06500107B2

公开(公告)日：2002-12-31

申请号：US09874731

申请日：2001-06-05

申请人： Richard I. Brown ,  Kyungyoon Min

发明人： Richard I. Brown ,  Kyungyoon Min

IPC分类号： B01D2126

CPC分类号： B04B5/0428 ,  A61M1/362 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/20 ,  B04B5/0442 ,  B04B2005/045 ,  C12M33/10

摘要： Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).

摘要翻译： 公开了从血液以外的流体浓缩和回收病原体的方法和装置。 该方法包括通过将流体连续地供给到一个或多个柔性室中并对该室进行离心力来浓缩包含在流体中的病原体。 浓缩的病原体可以通过摇动室来重新悬浮。

公开(公告)号：US6027657A

公开(公告)日：2000-02-22

申请号：US886732

申请日：1997-07-01

申请人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

发明人： Kyungyoon Min ,  Richard I Brown ,  Robert J Cantu

IPC分类号： A61K35/14 ,  A61M1/36 ,  A61M1/38 ,  B01D21/26 ,  B04B5/04

CPC分类号： B01D21/302 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  B01D21/262 ,  B04B5/0442 ,  B01D2221/10 ,  B04B2005/045

摘要： Systems and methods rotate a chamber, in which whole blood is centrifugally separated into packed red blood cells, a plasma constituent, and an interface between the packed red blood cells and the plasma constituent. The interface carries platelets and mononuclear cells. The systems and methods include an interface control unit. The interface control unit is operative in a first state to enable removal of platelet-poor plasma in a first container for use as a diluting liquid. In a second state, the interface control unit retains mononuclear cells in the chamber, while removing platelet-rich plasma from the chamber, bypassing the platelet-poor collection container, thereby maintaining its platelet-poor character. In a third state, the interface control unit enables the removal of mononuclear cells from the chamber in a path that leads to a second container, where the mononuclear cells are collected. The systems and methods direct platelet-poor plasma from the first container to the second container to dilute the removed mononuclear cells in the second container.

摘要翻译： 系统和方法旋转室，其中全血离心分离成包装的红细胞，血浆成分以及填充的红细胞和血浆成分之间的界面。 界面携带血小板和单核细胞。 系统和方法包括接口控制单元。 界面控制单元在第一状态下操作以使得能够在用作稀释液体的第一容器中移除贫血小血浆。 在第二状态下，界面控制单元在腔室中保留单核细胞，同时从腔室中除去富含血小板的血浆，绕过血小板收集容器，从而维持其血小板减少的特征。 在第三状态下，界面控制单元能够在通向收集单核细胞的第二容器的路径中从腔室去除单核细胞。 系统和方法将血小板从第一容器直接引导到第二容器，以稀释第二容器中去除的单核细胞。